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GI Hormones
GI hormones
36
Biology
Graduate
02/16/2013

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Term
location where Ghrelin is secreted
Definition
stomach
Term
location where Gastrin is secreted
Definition
gastric antrum and duodenal mucosa
Term
location where CCK is secreted
Definition
Duodenal and Jejenium mucosa
Term
location where Secretin is secreted
Definition
duodenal mucosa
Term
location where GIP is secreted
Definition
duodenal mucosa
Term
location where Motilin is secreted
Definition
duodenal mucosa
Term
Secretin inhibts:
Definition
-gastric emptying
-gastrin
-parietal cells
Term
CCK inhibits:
Definition
-gastric emptying
-gastrin
-parietal cells
-appetite
Term
Secretin stimulates:
Definition
-somatostatins
--pancreatic and gallbladder bicarb secretion
-exocrine cell mass growth of pancreas
Term
CCK functions:
Definition
-stimulates gall bladder contraction
-dilation of spincter of Oddi
-secretion of pancreatic enzymes
-potentiates bicarb secretion by pancreas
-growth of exocrine cell mass in pancreas and gallbladder
-inhibits parietal cell and gastrin secretion
Term
Gastrin Stimulates:
Definition
-secretion of pesinogen
-secretion of HCL
-growth of mucosa
-ECL cell
-gastric contractions
-activates gastroileal reflexes
Term
Gastrin inhibits:
Definition
-decreases LES muscle tone
Term
Vagus stimulates
Definition
Ach:
-Parietal cell
-ECL cell

GRP:
-G-cell
Term
Vagus inhibits:
Definition
Ach:
-D cells (somatostatin)
Term
Histamine stimulates:
Definition
-parietal cell
Term
Ghrelin stimulates:
Definition
-parietal cell
Term
Somatostatin inhibits:
Definition
-parietal cell
-G cell
Term
Somatostatin stimulates
Definition
-inhibitory g-protein
Term
GIP inhibits:
Definition
-parietal cell
-gastrin secretion
-gastric emptying
Term
Prostaglandins inhibit:
Definition
-parietal cell
Term
Prostaglandins stimulate:
Definition
-inhibitory g-cells
Term
Stimulators of pepsinogen
Definition
-cephalic/gastric: H+, gastrin, vagus
-Intestinal: H+, secretin
Term
VIP functions
Definition
-smooth muscle relaxer (esp LES)
-vasodilator
-increase water movement into pancreatic secretions and small intestine
-activates CFTR --> increase secretion of water and Cl into small intestine
Term
Motilin function
Definition
-stimulates contraction of stomach and small intestine - active during post absorptive time
-regulates MMC
Term
GIP stimulates
Definition
-insulin secretion by pancreatic B cells
Term
Ghrelin stimulates:
Definition
1. food intake
2. growth hormone production
3. Gastric secretion
4. gastric emptying
5. INHIBITS insulin secretion
Term
Stimulations of Motilin
Definition
-vagus, fat, low pH
Term
Stimulations of Gastrin
Definition
-digestion (AA, peptides, distention, vagal)
Term
Inhibitors of Gastrin
Definition
-low pH
-somatostatin
Term
Stimulators of CCK
Definition
-digestion (AA, peptides, monoglycerides, FA)
Term
Stimulators of Secretin
Definition
-low pH chyme in small intestine
Term
Stimulators of GIP
Definition
-glucose, AA, FA
Term
Histamine stimulates
Definition
-gastrin
-HCL
Term
Somatostatins inhibit:
Definition
-parietal cells
-G-cells
-growth hormone
-insulin and glucagon
Term
NE and ACh stimulate:
Definition
-relaxation of Smooth muscle
Term
Enkephalins (met- & leu-) stimulate:
Definition
smooth muscle contraction
-mediate spincter contractions
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