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GI hormones and secretions
gi
12
Medical
Graduate
05/26/2009

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Cards

Term
gastrin
Definition

gastric H+ secretion

growth of gastric mucosa

increased gastric motility

increased by stomach distention, amino acids, peptides, vagus nerve

decreased by pH < 1.5

Term
cholecystokinin
Definition

pancreatic secretion

gallbladder contraction

decreased gastric emptying

increased by fatty acids, amino acids

Term
secretin
Definition

pancreatic bicarbonate secretion

decreased gastric secretion

bile secretion

increased by acid, fatty acids in lumen of duodenum

needs pancreatic enzymes to function

Term
somatostatin
Definition

decreased acid and pepsinogen secretion decreased pancreatic and small intestine fluid secretion

decreased gall bladder contraction

decreased insulin and glucagon release

increased by acid

decreased by vagal stimulation

Term
gastric inhibitory peptide (GIP)
Definition

exocrine : decreased H+ secretion

endocrine : increased insulin release

increased by fatty acids, amino acids, oral glucose

Term
vasoactive intestinal polypeptide (VIP)
Definition

intestinal water and electrolyte secretion relaxation of intestinal smooth muscle and sphincters

increased by distention and vagal stimulation decreased by adrenergic input

Term
nitric oxide
Definition
smooth muscle relaxation, including LES
Term
motilin
Definition
produces MMCs (migrating motor complexes) increased in fasting state
Term
intrinsic factor
Definition
B12 binding protein for uptake in terminal ileum
Term
gastric acid (HCl)
Definition

decreased stomach pH

increased by histamine, ACh, gastrin

decreased by somatostatin, prostaglandin, secretin

Term
pepsin
Definition

protein digestion

increased by vagal stimulation, local acid

Term
HCO3-
Definition
neutralizes acid, prevents autodigestion
increased by secretin
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