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GI Definitions
Virginia Tech BMVS 4065
46
Physiology
Undergraduate 4
04/24/2008

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Term
Chyme
Definition
Partially digested food from stomach.
Term
Villi
Definition
Folds of the intestinal mucosal, divided further into microvilli. Each is supplied by an arteriole, capillary, venule and lymphatic cell.
Term
Ileoceclal Sphincter
Definition
Small intestine empties into the large intestine through this. Normally contracted but increased fluid content, pressure or chemical irritation of the ileum promotes relaxation.
Term
Pancreas
Definition
Secretes various enzymes that aid in intestinal digestion, including HC03- which neutralizes the acidic content of chyme entering the small intestine. Releases directly into the duodenum.
Term
Liver
Definition
Secretes bile which aids for fat digestion and nutrient absorption.
Term
Gallbladder
Definition

Stores bile during the interdigestive period. Empties contents into the duodenum during digestion.

 

CCK stimulates gallbladder contraction 

Term
Epithelial Cells
Definition
Cells specialized in different parts of the GI tract for secretion or reabsorption
Term
Muscularis Mucosa
Definition
Contraction causes a change in the surface area for secretion or absorption
Term
Circular Muscle
Definition
Contraction causes a decrease in diameter of the lumen of the GI tract.
Term
Longitudinal Muscle
Definition
Contraction causes shortening of a segment of the GI tract.
Term
Submucosal Plexus (Meisser's plexus) and Myenteric Plexus
Definition
Integrates and coordinates the motility and endocrine functions of the GI tract.
Term
Peristalis
Definition

Typical movement of food away from the mouth through the GI tract. Circular layer of muscle contracted behind the bolus of food, then the "ring" is pushed forward by longitudinal muscles.

 

Occurs in esophagus, distal stomach, small and large intestines 

Term
Segmentation (Mixing) Movement
Definition
Rythmic contractions of circular muscle layer that serve to mix and divide the intestinal contents. Occurs in small and large intestine.
Term
Tonic Contractions
Definition
Sustained contraction for blocking passages, compartmentation, and pressure maintenance. Occurs in sphincters and proximal stomach.
Term
Sphincters
Definition
Promote one-way movement of luminal contents. Contracted circular muscle that relax in response to nerve or hormonal stimulation.
Term
Chewing
Definition

Breaks food into small pieces

MIxes food with salivary gland secretions

Contact with taste buds initiate gastric secretions 

Term
Parotid Glands
Definition
Located near the angle of the jaw, largest glands. Secrete watery fluid (serous)
Term
Submandibular and Sublingual Glands
Definition
Secrete a fluid that contains higher concentration of protein and is more viscous
Term
Saliva
Definition
Serous secretions enriched in alpha-amylase and mucous secretions enriched in mucin. Prevents dehydratoin of th eoral mucosa and provide lubrication for chewing and swelling of digested food. Begins processing of starch and fat.
Term
alpha-amylase
Definition
Processes starch (found in saliva)
Term
Esophagus
Definition
Muscular mucus lined tube that connects the pharynx with the stomach. Passageway for food.
Term
Gastric Reflux (heartburn)
Definition
Tone of lower esophageal sphincter is decreased and gastric content reflux into the esophagus.
Term
Achalasia
Definition
Occurs if lower esophageal sphincter does not relax during swallowing and food accumulates in the esophagus and food isn't able to enter stomach.
Term
Antrum
Definition
Part of the stomach that respond to nervous control. Muscle layers are thick and the strength of contraction is greater.
Term
Proximal Stomach
Definition
Section of stomach with slow tonic contractions and high distensibility. Reservoir for stomach ingested food. No slow waves seen here.
Term
Distal Stomach
Definition
Section of stomach with slow waves and peristalic phasic contractions that sweep toward the pylorus. Distensibility here is low.
Term
Pylorus
Definition
Narrow opening at the bottom of the stomach leading towards the duodenum.
Term
Retropulsion
Definition
Process where food not small enough to fit through the Pylorus is propelled backward for further mixing and grinding.
Term
Cholecystokinin (CCK)
Definition
released from epithelium of duodenum. Stimulates contraction of the pyloric sphincter, slowing gastric emptying allowing more time for fat to mix with pancreatic liipase and bile salts in the duodenum
Term
Cephalic Phase Secretion
Definition

Gastric acid secretion initiated by the thought, sight, taste, or smell of food. Dependent on the integrity of the vagal fibers innervating the stomach. Contributes 50% of gastric secretion.

 

Pancreatic Secretion initiated by the same. 20% of pancreatic response. 

Term
Gastric Phase Secretion
Definition

Gastric Acid secretion initiated by the entry of food into the stomach. Food entering the stomach raises pH causing release of acid to lower pH. Low pH inhibits gastrin secretion.

 

Pancreatic Secretion initiated by the same. Enzyme output increased more than HCO3- secretion. 5-10% of pancreatic secretion. 

Term
Intestinal Phase Secretion
Definition
Gastric Acid secretion begins when chyme empties from the stomach into the duodenum. Overal, very little secretion happens.
Term
Gastric Ulcers
Definition

Created by H+ and pepsin injuring the gastric mucosa when the normal protective barrier of the stomach is damaged. 

Term
Helicbacter Pylori Infection
Definition
Major cause of gastric ulcers. H. pylori converts urea to NH4+, which damages the gastric mucosa.
Term
Duodenal Ulcers
Definition
Created due to higher than normal H+ secretion, gastrin levels, or parietal cell mass inreased
Term
Pancreatic Juice
Definition
Contains water, bicarbonate, and three main enzymes: Amylase, Trypsin, and Lipase
Term
Amylase
Definition
Enzyme contained in Pancreatic Juice that digests starch
Term
Trypsin
Definition
Enzyme contained by pancreatic juice that digests proetin
Term
Enterohepatic Circulation
Definition
Recirculation of bile salts from the liver to the small intestine and back again. Necessary because of the limited pool of bile salts available. 90-95% of bile salts enter the small intestine actively reabsorped. Remaining excreted in feces.
Term
Gallstones
Definition
Clumps of material, mostly (85%) cholesteral that form in the gallbladder. Formed when cholesterol concentration in bile becomes excessive causing crystallization.
Term
Cholecystectomy
Definition
Removal of the gallbladder. Bile empties slowly but continually into the intestine. High fat meals need to be avoided, but otherwise normal digestion of fat is possible.
Term
Large Intestine
Definition

Enhances efficiency of water and electrolyte absorption

Stores colonic content

Promotes excretion of fecal material remaining in the colon regularly and voluntarily. 

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