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GI Antiviral Drugs
Downstate > MS2 GI Block > Drugs
37
Medical
Graduate
12/09/2010

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Term
who receives hepA vaccine?
Definition
children >1yo, travelers, medical personnel, military personnel
Term
for which hep viruses do we have vaccines for?
Definition
hepA, hepB
Term
MOA of action of lamivudine, telbivudine, adefovir, tenofovir, entecavir
Definition
inhibits DNA polymerase/RT, chain terminator
Term
active form is the triphosphate form
Definition
lamivudine, telbivudine
Term
active form is the diphosphate form
Definition
adefovir
Term
indicated for lamivudine-resistant strains of hepB
Definition
adefovir, tenofovir
Term
drugs for chronic hepB
Definition
lamivudine, telbivudine, adefovir, tenofovir, entecavir
Term
tx for chronic hepC
Definition
IFN alfa-2b + ribavirin
Term
AE of telbivudine
Definition
myopathies
Term
AE of tenofovir
Definition
renal impairment, reduced bone density
Term
AE of ribavirin
Definition
10-20% hemolytic anemia
Term
functions of PEGylation
Definition
increases half life, decreases clearance
Term
5-ASA azo compounds
Definition
sulfasalazine, balsalazide, olsalazide
Term
indications for sulfasalazine, balsalazide, olsalazide
Definition
mild to moderate IBD
Term
time release capsule best for distribution throughout small intestine
Definition
pentasa
Term
pH sensitive drug best for absorption in terminal ileum and colon
Definition
asacol
Term
indication and administration for hydrocortisone
Definition
UC; topical, foam suppository
Term
indication and administration for budesonide
Definition
Crohn's; oral
Term
delayed therapeutic response takes weeks to months
Definition
purine analogs: 6-mercaptopurine or azothioprine
Term
AE: dose-dependent bone marrow suppression; indicated for Crohn's
Definition
methotrexate
Term
AE: megaloblastic anemia; indicated for Crohn's
Definition
methotrexate
Term
AE: risk of URI, TB reactivation
Definition
infliximab
Term
fully humanized anti-TNFa
Definition
adalimumab
Term
chimera anti-TNFa
Definition
infliximab
Term
probiotics
Definition
lactobacillus, bifidobacterium
Term
antibiotics used for Crohn's Disease
Definition
metronidazole, ciprofloxacin, clarithromycin
Term
drugs specifically indicated for Crohn's
Definition
budesonide, methotrexate, adalimumab, infliximab, certolizumab pegol, antibiotics, probiotics
Term
indicated for IBS-C
Definition
tegesarod, lubiprostone
Term
MOA of dicyclomine
Definition
antispasmodic; anticholinergic
Term
5-HT4 receptor agonist
Definition
tegesarod
Term
5-HT3 blocker
Definition
alosetron
Term
indication for alosetron
Definition
IBS-D
Term
cardiovascular side effects
Definition
tegesarod
Term
tx for gallstones
Definition
ursodial
Term
MOA of ursodial
Definition
decreases cholesterol content and dissolves gallstones
Term
MOA of tegasarod
Definition
5-HT4 receptor agonist; increases peristalsis and Cl- secretion
Term
resistance occurs in up to 50% of patients who have been on treatment for 3 years
Definition
lamivudine
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