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Genetics
Exam 2
75
Biology
Undergraduate 4
02/15/2009

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Term
What are 3 types of chromosomal rearrangements?
Definition
Duplication, Deletion, relocation(translocation and inversion)
Term
What are the 3 types of duplication
Definition
tandem A B *C D E F G E F G
displaced A B *C D E F G A B
reverse A B B A *C D E F G
Term
What are the 2 types of inverstion
Definition
pericentric A D*C B E F G
paracentric A B *C F E D G
Term
What are 2 types of translocation?
Definition
reciprocal: same homologous size
nonreciprocal: not the same
Term
Robertsonian translocation
Definition
fusion between non-homologous chromosomes at their centromeres
Term
Results of Crossing Over within a Paracentric Inversion
Definition
Dicentric chromatid
Acentric chromatid
Term
Aneuploidy & Polyploidy
Definition
Aneuploidy: change in the number of individual chromosomes
Polyploidy: full set of extra chromosomes
Term
Reciprocal Translocation chromosome separation
Definition
[image]
Term
3 types of aneuploidy
Definition
Nullisomy (monosomy), Trisomy, tetrasomy
Term
Nullisomy
Definition
Loss of both members of a homologous pair (2n - 2)
Term
Monosomy
Definition
Loss of one member of a homologous pair (2n – 1)
Term
Trisomy
Definition
Gain of a single chromosome (2n + 1)
Term
Tetrasomy
Definition
Gain of a pair of homologous chromosomes (2n + 2
Term
Which is the only viable monosomy?
Definition
XO, Turner syndrome
Term
Autopolyploidy
Definition
chromosome duplication within a species
Term
Allopolyploidy
Definition
hybridization of two species
Term
Gene pool
Definition
set of genes in the population
Term
How to find the frequency of allele
Definition
number of that allele/ total
Term
Hardy-Weinburg equation
Definition
p2 + 2pq + q2 = 1.0
Term
what are the assumptions for Hardy-Weinburg equation
Definition
large population, no migration, no mutation, random mating, no natural selection
Term
Chi square for linkage
Definition
Finding whether they are independently assorted
Term
what does 50% recombination
Definition
Will occur between two Unlinked genes by independent assortment

Can occur between two Linked genes that are far apart
Term
recombination frequency
Definition
# recombinant progeny/Total # progenyX100
Term
coupling configuration /cis
Definition
AB/ab
Term
repulsion/trans configuration
Definition
aB/Ab
Term
interchromosomal recombination
Definition
genes from different chromosome
Term
intrachromosomal recominbation
Definition
genes from same chromosome
Term
genetic map
Definition
chromosome map calculated by using the genetic phenomenon of recombination
Term
physical map
Definition
calculated by using physical distance along the chromosome
Term
map uni and CentiMorgan
Definition
1%=1m.u=100Cm.u.
Term
expected number for linked
Definition
row total x column total / grand total
Term
df for linked
Definition
(row-1)(column-1)
Term
interference
Definition
1- coefficient of coincidence
Term
coefficient of coincidence
Definition
observed DCO/expected DCO
Term
how to find expected DCO
Definition
(map unit)(map unit)/ total numbers
Term
lod score
Definition
Term
genetic marker
Definition
Term
deletion mapping
Definition
Term
somatic-cell hybridization
Definition
Term
cell line
Definition
Term
heterokaryon
Definition
Term
Hardy-Weinburg assumptions
Definition
large population, no migration, no mutation, no natural selection, random mating
Term
equation of Hardy-Weinburg
Definition
p2 + 2pq + q2
Term
2 types of non-random mating
Definition
positive assortative mating and negative assortative mating
Term
Positive assortative mating
Definition
like individuals mate.
Term
Positive assortative mating
Definition
like individuals mate.
Term
Negative assortative mating
Definition
unlike individuals mate.
Term
inbreeding
Definition
Causes deviations in the HW-equilibrium specifically the heterozygotes decrease and can eventually disappear.
Term
Outcrossing
Definition
specific avoidance of inbreeding.
Term
Inbreeding Coefficient(F)
Definition
Ranges from 0 to 1
0 is random mating, 1 is self fertilization
Term
inbreeding and its change in allele
Definition
The heterozygotes decrease by 2Fpq
Homozygotes increase by Fpq
Term
Inbreeding Depression
Definition
The increased appearance of lethal and deleterious traits due to inbreeding
Term
Migration and its effects
Definition
Prevents populations from becoming genetically isolated from each other.
Increases genetic variation within populations
Term
Genetic Drift
Definition
changes in allelic frequency
Term
genetic drift and population size
Definition
When populations are LARGE genetic drift is reduced.
When populations are SMALL genetic drift is increased.
Term
Fitness (W):
Definition
Natural selection. the relative reproductive success of the genotype and ranges from 0 to 1.
Term
Calculating Fitness
Definition
Take the average number of offspring produced by a genotype and divide it by the average number of offspring produced by the most prolific genotype
Term
W11 = W12 > W22
Definition
Directional Selection against recessive A2
Term
W11 = W12 < W22
Definition
Directional Selection against dominant A1
Term
W11 > W12 > W22
Definition
Directional Selection against incompletely dominant A2
Term
W11 < W12 < W22
Definition
Directional Selection against incompletely dominant A1
W11 < W12 > W22 Overdominance
Term
W11 < W12 > W22
Definition
Overdominance
Term
W11 > W12 < W22
Definition
Underdominance
Term
what's the other name for overdominance?
Definition
heterozygous adventage
Term
Underdominance
Definition
will not result in changes in allelic frequency unless another factor contributes. Then alleles tend towards fixation.
Term
Penetrance
Definition
% individuals with the genotype that show the phenotype
Term
Expressivity
Definition
variation of the intensity of a phenotype
Term
incomplete penetrance
Definition
no phenotypic expression
Term
Can Environment affect the expression of an allele
Definition
yes
Term
Multiple alleles/ allelic series
Definition
hierarchy of dominance!
MR > M > md
Term
sex-influenced characteristics
Definition
autosomal genes that are expressed differently in males and females
Term
sex-limited characteristic
Definition
an extreme form of sex-influenced inheritance. expressed in only one sex.
Term
Epistasis
Definition
In polygenic traits, the expression of one gene hides the expression of another gene
Term
Recessive Epistasis
Definition
dogs
Term
Dominant Epistasis
Definition
Dominant allele is an INHIBITOR
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