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Genetics replication vocab
Replication vocab
21
Biology
Undergraduate 1
10/04/2012

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Term
Replicator
Definition
Sequence of DNA that initiates replication
Term
Origin of replication
Definition
Specific region where DNA denatures into single strands and within which replication commences
Term
Replication bubble
Definition
Locally denatured segment of DNA
Term
Template strands
Definition
Single strands of the replication bubble on which new DNA is made
Term
Replication forks
Definition
Y-shaped structure formed when DNA untwists
Term
Bidirectional replication
Definition
Synthesis of DNA in both directions away from an origin of replication
Term
Initiator protein
Definition
Binds to replicator and denatures the A-T rich region
Term
DNA helicase
Definition
An enzyme that catalyzes unwinding of DNA double helix at replication fork during DNA replication
Term
DNA primase
Definition
Enzyme that catalyzes formation of a short RNA primer in DNA replication
Term
Primosome
Definition
A complex of primase, helicase, and other proteins that function in DNA synthesis
Term
Single stranded DNA-binding (SSB) proteins
Definition
Stabilize each single stranded DNA and prevents them from rejoining
Term
Leading strand
Definition
New strand of DNA being synthesized in the same direction as the movement of the replication fork
Term
Lagging strand
Definition
New strand of DNA being synthesized in the opposite direction as the movement of the replication fork
Term
Semidiscontinous replication
Definition
One strand of DNA is synthesized continuously, the other is not
Term
Okazaki fragments
Definition
Fragments of lagging strand DNA
Term
DNA ligase
Definition
Joins together Okazaki fragments
Term
Replisome
Definition
Proteins closely associated form together and bind to replicating DNA
Term
Rolling circle replication
Definition
Double stranded DNA replicates to produce linear DNA
Term
Replicon
Definition
Stretch of DNA from the origin of replication to the two termini of replication
Term
Autonomously replicating sequences
Definition
Replicators in eukaryotes of approximately 100 base pairs
Term
Origin recognition complex (ORC)
Definition
Initiator protein in eukaryotes
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