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Genetics Ch. 1
Genetics Ch. 1
65
Biology
Undergraduate 2
01/23/2006

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Term
adenine
Definition
a nitrogenous purine base found in DNA and RNA
Term
amino acid
Definition
any one of a class of organic molecules that have an amino group and a carboxyl group; 20 different amino acids are the usual components of protein
Term
Archaea
Definition
One of the three major classes of organisms previously called archaebacteria, they are unicellular microorganisms, usually found in extreme environments, that differ as much from bacteria as either group differs from eukaryotes. an archaeon is a single cell or species of archaea
Term
Bacteria
Definition
One of the major kingdomes of living things
Term
bacteriophage
Definition
A virus that infects bacterial cells; commonly called a phage
Term
Bacteria
Definition
One of the major kingdomes of living things
Term
base
Definition
single ring (pyrimidine) or double ring (purine) component of a nucleic acid
Term
biochemical pathway
Definition
a diagram showing the order in which intermediate molecules are produced in the synthesis or degradation of a metabolite in a cell
Term
block
Definition
in a biochemical pathway, a defective step at which the normal biochemical reaction cannot be carried out, often because of a defective enzyme endcoded by a mutant gene.
Term
Central dogma
Definition
the concept that genetic information is transferred from the nucleotide sequence in DNA to the nucleotide sequence in an RNA transcript to the amino acid sequence of a polypeptide chain
Term
Chaperone
Definition
A protein that assists in the three dimensional folding of another protein
Term
Chromosome
Definition
In eukaryotes, a DNA molecule that contains genes in linear order to which numerous proteins are bound and that has a telomere at each end and a centromere; in prokaryotes, the DNA is associated with fewer proteins, lacks telomeres and a centromere, and is often circular; in viruses, the chromosome is DNA or RNA, single stranded or double stranded, linerar or circular, and often free of bound proteins
Term
Codon
Definition
A sequence of three adjacent nucleotides in an mRNA molecule, specifying either an amino acid or a stop signal in protein synthesis
Term
Colony
Definition
A visible cluster of cells formed on a solid growth medium by repeated division of a single parental cell and its daughter cells
Term
cytosine
Definition
a nitrogenous pyrimidine base found in DNA and RNA
Term
deoxyribose
Definition
The five carbon sugar present in DNA
Term
DNA deoxyribonucleic acid
Definition
the macromolecule, usually composed of two polynucleotide chains in a double helix, that is the carrier of the genetic information in all cells and many viruses
Term
double stranded DNA; duplex DNA
Definition
A DNA molecule consisting of two antiparallel stands that are complementary in nucleotide sequence
Term
enzyme
Definition
A rotein that catalyzes a specific biochemical reaction and is not itself altered in the process
Term
eukarya
Definition
one of the major kingdoms of living organisms, in which the cells have a true nucleus and divide by mitosis or meiosis
Term
eukaryote
Definition
a cell with a true nucleus (DNA enclosed in a membranous envelope) in which cell division takes place by mitosis or meiosis; an organism is composes
Term
Evolution
Definition
cumulative change in the genetic characteristics of a species through time, resulting in greater adaptation
Term
gene
Definition
the hereditary unit containing genetic information transcribed into an RNA molecule that is processed and either functions directly or is translated into a polypeptide chain; a gene can mutate to varous forms called alleles
Term
genetic code
Definition
the set of 64 triplets of bases (codons) corresponding to the twenty amino acids in proteins and signals for initiation and termination of polypeptide synthesis
Term
genetics
Definition
the study of biological heredity
Term
genome
Definition
the total complement of genes contained in a cell or virus; in eukaryotes, commonly used to refer to all genes present in one complete haploid set of chromosomes
Term
guanine
Definition
a nitrogenous purine base found in DNA and RNA
Term
homogentisic acid
Definition
the molecule, formerly called alkapton, that is excreted in the urine of alkaptonurics and turns black upon oxidation
Term
Inborn error of metabolism
Definition
a genetically determined biochemical disorder, usually in the form of an enzyme defect that produces a metabolic block
Term
Messenger RNA (mRNA)
Definition
An RNA molecule transcribed from a DNA sequence and translated into the amino acid sequence of a polypeptide. In eukaryotes, the primary transcript undergoes elaborate processing to become the mRNA
Term
Metabolic pathway
Definition
A set of chemical reactions that take place in a definite order to convert a particular starting molecule into one or more specific products
Term
metabolite
Definition
any small molecule that participates in metabolism as a substrate, product, or cofactor
Term
monomer
Definition
Any of the individual polypeptide chains (subunits) that make up a protein composed of multiple polypeptide chains
Term
Mutant
Definition
Any heritable biological entity that differs from wild type, such as a mutant DNA molecule, mutant allele, mutant gene, mutant chromosome, mutant cell, mutant organsism, or mutant heritable phenotype; also a cell or organism in which a mutant allele is expressed
Term
mutation
Definition
a heritable alteration in a gene or chromosome; also, the process by which such an alteration happens. used incorrectly, but with increasing frequency, as a synonym for mutant, even in some excellent textbooks
Term
Native conformation
Definition
the three dimensional shape that a molecule is thought to acquire inside the cell
Term
nucleotide
Definition
A purine or pyrimidine base covalently linked to a sugar phosphate
Term
oligomerization domain
Definition
a region of a polypeptide chain that binds to a region of another polypeptide chain to form a protein with two or more subunits
Term
Pleiotrophic effect
Definition
any phenotypic effect that is a secondary manifestation of a mutant gene
Term
pleiotropy
Definition
the condition in which a single mutant gene affects two or more distinct and seemingly unrelated trails
Term
polarity (DNA or RNA)
Definition
the 5'to 3'orientation of a strand of nucleic acid
Term
polypeptide chain
Definition
a polymer of amino acids linked together by peptide bonds
Term
prokaryote
Definition
an organism that lacks a nucleus; these cells divide by fission
Term
protein folding
Definition
the process by which a polypeptide chain conforms itself in three dimensions to attain its native conformation
Term
protein folding
Definition
the process by which a polypeptide chain conforms itself in three dimensions to attain its native conformation
Term
protein folding
Definition
the process by which a polypeptide chain conforms itself in three dimensions to attain its native conformation
Term
replication
Definition
the copying of a DNA molecule
Term
Ribonucleic Acid (RNA)
Definition
Ribonucleic acid, a nucleic acid in which the sugar constituent is ribose; typically, is a single stranded and contains the four bases adenine,cytosine, guanine, and uracil
Term
Ribose
Definition
The 5 carbons sugar in RNA
Term
Ribosomal RNA
Definition
RNA molecules that are components of the ribosomal subunites; in eukaryotes, there are four rRNA molecules
Term
ribosome
Definition
the cellular organelle on which the codons of mRNA are translated into amino acids in protein synthesis, ribosomes consist of two subunits, each composed of RNA and proteins. In prokaryotes, the subunits are 30S and 50S particles; in eukaryotes, they are 40S and 60S particles
Term
single stranded DNA
Definition
A DNA molecule that consists of a single polynucleotide chain
Term
substrate molecule
Definition
a substance acted on by an enzyme
Term
template
Definition
A nucleic acid strand whose base sequence is copied in a polymerization reaction to produce either a complementary DNA or RNA strand
Term
tetramer
Definition
A protein composed of four polypeptide subunits, which may or may not be identical
Term
thymine
Definition
a nitrogenous pyrimindine base found in DNA
Term
transcript
Definition
An RNA strand that is produced from, and is complementary in base sequence to, a DNA template strand
Term
transcription
Definition
the process by which the information contained in a template strand of DNA is copied into a single stranded RNA molecule of complementary base sequence
Term
transfer RNA tRNA
Definition
A small RNA molecule that translates a codon into an amino acid in protein synthesis; it has a three base sequence, called the anticodon, complementary to a specific codon in mRNA, and a site to which a specific amino acid is bound
Term
transformation
Definition
Change in the genotype of a cell or organism resulting from exposure of the cell or organism to DNa isolated from a different genotype; also, the conversion of an animal cell, whose growth is limited in culture, into a tumor like cell whose pattern of growth is different from that of a normal cell
Term
translation
Definition
the process by which the amino acid sequence of a polypeptide is synthesized on a ribosome according to the nucleotide sequence of an mRNA molecule
Term
uracil
Definition
a nitrogenous pyrimidine base found in RNA
Term
Watson crick pairing
Definition
base pairing in DNA or RNA in which A pairs with T or with U in RNA and G pairs with C
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