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Genetics 2
test 2
65
General Vocab
Not Applicable
03/22/2013

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Term
CentiMorgan
Definition
distance unit on a genetic map
Term
genetic map
Definition
, Representation of relative distances separating genes on a chromosome based on the frequencies of recomination between nonallelic gene loci
Term
gene markers
Definition
alleles that produce detectable phenotypes useful in genetic analysis.
Term
genetic markers
Definition
any gene or dna region that whose sequence varies among individuals and is useful in genetic analysis.
Term
genetic recombination
Definition
Process by which parents with different alleles give rise to progeny with different phenotypes than either parent
Term
linkage
Definition
tendency for genes on same chromosome to be inherited in manner that is inconsistent with Principle of Independent Assortment
Term
linkage map
Definition
genetic map
Term
parental genotypes
Definition
genetic makeup of individuals in the parental generation of genetic crosses.
Term
recombinants
Definition
chromosome, cell or individual that has nonparental combinations of genetic markers as a result of recombination
Term
three-point testcross
Definition
Cross between an individual heterozygous at three loci with an individual homozygous for recessive alleles at the same three loci. Used for maping linked genes
Term
aneuploidy
Definition
Any condition in which the number of chromosomes differs from an exact multiple of the normal haploid number in a cell. Results from the gain or loss of individual chromosomes, or duplication or deletion of parts of a chromosome.
Term
Autopolyploidy
Definition
, Condition in which a cell or organism has two or more genetically distinct sets of chromosomes of the same species
Term
chromosomal aberrations
Definition
variation from the wild type condition in chromosome number or structure.
Term
deletion
Definition
chromosomal mutation resulting in the loss of a segment of a chromosome and the gene sequences
Term
dicentric chromosome
Definition
homologous chromosome pair in meiosis I in which one chromatid has two centromeres as the result of crossing over within a paracentric inversion. As the two centromeres begin to migrate to opposite poles, a dicentric bridge stretching across the cell forms and eventually breaks
Term
Duplication
Definition
Chromosomal mutation that results in the doubling of a segment of of a chromosome and the gene sequences it contains
Term
Euploid
Definition
Referring to an organism or cell that has one complete set of chromosomes or an exact multiple of complete sets
Term
Inversion
Definition
chromosomal mutation in which a segment of a chromosome s excised and then reintegrated in an orientation 180 degrees from the original orientation
Term
Monoploidy
Definition
condition in which a normally diploid cell or organism lacks one complete set of chromosomes.
Term
Monosomy
Definition
a type of aneuploidy in which one chromosome of a homologous pair is missing from a normally diploid cell or organism lacks one complete set of chromosomes
Term
Paracentricinversion
Definition
mutation in which a segment on one chromosome arm that does not include the centromere is inverted
Term
pericentric inversion
Definition
mutation in which a segment on one chromosome arm that includes the centromere is inverted
Term
Polyploidy
Definition
condition in which a cell has more than two sets of chromosomes
Term
Robertsonian translocation
Definition
Type of nonreciprocal translocation in which the long arms of tho nonhomologous acrocentric chromosomes become attached to a single centromere
Term
Translocation
Definition
chromosomal mutation involving a change in the position of a chromosome segment and the gene sequences it contains
Term
trisomy
Definition
type of aneuploidy in which a normally diploid cell posseses three copies of a particular genome instead of two
Term
Trisomy-13
Definition
Patau
Term
trisomy-18
Definition
Edwards
Term
trisomy-21
Definition
Down
Term
antiparallel
Definition
opposite orientation of DNA strands
Term
chromatin
Definition
DNA-protein complex that constitutes eukaryotic chromosomes and can exist in various degrees of folding or compaction
Term
Chromosomes
Definition
single dna molecule complexed with protein
Term
complementary base pairs
Definition
specific a-t/c-g in double stranded dna
Term
euchromatin
Definition
condensed during mitosis and uncoils in telophase to be transcribed.
Term
genome
Definition
total amount of genetic material in a chromosome set. (haploid set)
Term
heterochromatin
Definition
Cromatin that remains condensed throughout the cell cycle and is usually not transcribed
Term
histones
Definition
class of basic proteins that are complexed with DNA in Chromatin and play a major role in determining the structure of nuclear chromosomes.
Term
nitrogenous
Definition
base, purine or pyrimidine containing nitrogen along with pentose and phosphate group as part of a nucleotide
Term
nucleic acids
Definition
high molecular weight polynucleotide, cells in dna and rna
Term
nucleotides
Definition
base, sugar, and phosphate group
Term
phosphodiester bonds
Definition
covalent bond in dna between a sugar of one nucleotide and a phosphate group of another. Provide backbone
Term
purines
Definition
Adenine and guanine
Term
pyrimidines
Definition
Cytosine and thyrosine, uracil
Term
ribonucleotide
Definition
rna base sugar and phosphate group
Term
ribonucleic acid
Definition
single stranded polymeric molecule
Term
tandemly repeated DNA
Definition
repetitive dna sequences that are clustered together in the genome, so that each such sequence is repeated many times in a row within a particular chromosomal region.
Term
Topoisomerases
Definition
enzyme that catalyzes the supercoiling of Dna
Term
DNA helicase
Definition
unwinding dna double helix at replication fork
Term
DNA ligase
Definition
forms a phosphodiester bond between 5' of one and 3' of another during transcription and repair.
Term
lagging strand
Definition
Dna strand synthesized discontinuously in transcription
Term
leading strand
Definition
strand synthesized continuously in transcription.
Term
Okazaki fragments
Definition
, short singlestranded dna fragments that are sythesized on the lagging strand template
Term
origin of replication
Definition
specific region in dna that double helix unwinds and synthesis begins.
Term
primase
Definition
formation of a short rna primer in replication
Term
replication bubble
Definition
, locally unwound region of dna bounded by replication forks at which dna synthesis proceeds in opposite directions.
Term
replication fork
Definition
y shaped structure formed when double stranded dna unwinds to expose the template
Term
RNA primer
Definition
short rna chain produced by primase during replication to which dna polymerase adds nucleotides, extending dna strand
Term
single-strand DNA-binding (SSB) proteins
Definition
binds to the unwound dna strands at replication bubble and prevents them from reannealing.
Term
template strands
Definition
strand which is synthesized for a complementary strand during transcription
Term
Nullisomic
Definition
2N-2
Term
Monosomic
Definition
2N-1
Term
Trisomic
Definition
2N+1
Term
Tetrasomic
Definition
2N+2
Term
Triploid
Definition
3N
Term
Tetraploid
Definition
4N
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