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Definition
| focal collection of purulent inflam tissue w. central necrotic area, surrounded by neutrophils then fibrous tissue |
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Definition
abnormal fibrous attachment between adjacent organs and tissues e.g. lungs and pleura
May occur due to organisation of surface exudate |
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Definition
| cell / tissue degeneration post mortem may resemble changes in necrosis but no inflam response present |
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Term
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Definition
| blue when stained with haematoxylin in H&E |
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Term
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Definition
| chemoattractant cytokines - induce cells to move towards them up a conc. grad. |
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Term
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Definition
protein soluble factors released by one cell that bind specific receptors on the same or other cell leading to altered cell function
-mediators of inflam and im. responses |
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Term
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Definition
retrogressivve change affecting cells / tissues, initially cytoplasmis changes, then nuclear.
Reversible but can lead to necrosis if insult is prolonged or severe |
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Term
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Definition
Abnormal deposition of calcium when tissue is degenerate or necrotic
i.e. normal serum calcium levels |
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Definition
Pink when stained with eosin in H&E
e.g. fibrin presence |
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Definition
local defect / excavation on surface of an organ or tisse due to sloughing of necrotic tissue
-incl. loss of epithelium but BM remains intact |
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Term
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Definition
| material with HIGH cell and protein content which has leaked from vessels into adjacent tissues and spaces, in inflam. |
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Term
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Definition
insoluble protein formed by the interaction of thrombin and fibrinogen
Fibrinogen --> Fibrin
converted by thrombin action |
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Term
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Definition
a protein present in blood plasma and serous exudates
converted to fibrin by thrombin action |
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Term
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Definition
-degeneration in which tissue involved is converted to a homogenous mass with bright eosinophilc staining due to firbin
-other proteins present incl. Ig and C
-usually applied to b.v. |
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Term
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Definition
| contains or resembles fibrin |
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Term
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Definition
Fibrous tissue, contains COLLAGEN
NB: no fibrin! |
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Term
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Definition
formation / deposition of fibrous tissue (i.e. collagen) c.t.
i.e. scar formation |
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Term
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Definition
a central causal agent surrounded by a circumscribed aggregation or focus of macrophages, surrounded by lymphocytes +/- plasma cells
-a chronic response to a persistant agent |
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Term
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Definition
inflam reaction consisting of mainly macrophages w. other cells e.g. PCs
- usually chronic response to persistent agent |
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Term
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Definition
formed as part of healing / repair process frollowing tissue damage
-composed of new cap. and fibroblasts producing collagen in basket weave pattern |
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Term
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Definition
| microscopic description for a substance stained with H&E which appears homogenous, eosinophilic (pink), glassy, translucent / transparent |
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Definition
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Term
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Definition
| Abnormal deposition of calcium when tissue is healthy but serum calcium levels are elevated |
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Definition
Spectrum or morphological changes that follow cell death in living tissue.
-irreversible
-often associated w. inflam response. |
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Term
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Definition
| part of the repair process following injury - ingrowth of new vessels and fibroblasts into a fibrin meshwork, leading to the formulation of GRANULATION TISSUE then FIBROUS TISSUE |
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Term
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Definition
| inflam reaction comprisinf infiltrate of neutophils amd macrophages, often w. PCs, |
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Term
| Reactive Oxygen Species (ROIs) |
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Definition
| Oxygen free radicals which can damage lipids, proteins, nucleic acids |
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Term
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Definition
Temporary patch on damaged b.v. wall composed of fibrin and platelets
-result of haemostasis |
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Term
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Definition
| Pathological clotting in CVS i.e. thrombi form inappropriately in b.v. |
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Term
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Definition
extravascular fluid with LOW protein content and LOW specific gravity
Results from incr. fluid pressures or dec. colloid oncotic forces in plasma |
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Term
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Definition
local defect / excavation on surface of an organ or tisse due to sloughing of necrotic tissue
-incl. loss of epithelium and breach of BM |
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