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General Genetics
College Level Genetics
54
Biology
11th Grade
09/27/2011

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Term
Linkage
Definition
Genes on the same Chromosome
Term
Recombination
Definition
Process that produces new combinations of alleles
Term
Crossover
Definition
Exchange of genetic material between homologous but nonsister chromatids
Term
Chiasmata
Definition
Point of attachment between homologous chromosomes at which crossing over took place
Term
Complete linkage
Definition
only 2 kinds of offspring, like the parents
Term
Incomplete Linkage
Definition
recombination produces a few of the other 2 kinds of offspring
Term
Testcross
Definition
a cross between an individual with an unknown genotype and an individual with the homozygous recessive genotype
Term
How many chromatids take part in crossover?
Definition
2
Term
How many chromatids can be found on a double crossover?
Definition
3-4
Term
More space between 2 genes
Definition
more likely that they will be separated by recombination during meiosis
Term
Map Units
Definition
Distance assumption unit for recombination
Term
Maximum distance of a Recombination
Definition
50 Map Units
Term
What happens when map units go over 50?
Definition
It becomes impossible to tell between recombination and independent assortment.
Term
Why won't double crossovers be detected?
Definition
they return alleles to parental arrangements
Term
SNP
Definition
single base mutations that are “alleles” even when not in genes
Term
Haplotypes
Definition
set of linked alleles
Term
Deletion Mapping
Definition
Estimate locus of gene by crossing recessive homozygotes to deletion heterozygotes
Term
Somatic Cell Hybridization
Definition
Find which chromosome a gene is on by creating reduced-chromosome cell lines (Hamster-human hybrids)
Term
Nutritional Mutants
Definition
Lack some nutrient due to defective food processing gene; Mutant cells survive if fed missing nutrient
Term
Antibiotic Resistance
Definition
Some cells make special protective proteins to block antibiotics
Term
Plasmids
Definition
Small, non-vital, circles of DNA
Term
When does recombination happen in bacteria
Definition
Recombination happens when part of bacterial genome is temporarily diploid; “Extra” DNA is moved into the cell by one of three different mechanisms
Term
Transformation
Definition
small pieces of free DNA are pulled in through cell membrane
Term
Conjugation
Definition
DNA is transferred during bacterial “sex”
Term
Transduction
Definition
DNA is transferred by phages
Term
Incorporation by Recombination
Definition
Newly transferred DNA can be incorporated into bacterial genome by recombination; Similar to recombination between homologous chromosomes in diploids; Must have double crossover to successfully incorporate DNA
Term
Imported linear DNA is either....?
Definition
degraded or recombined with matching DNA on host chromosome
Term
pili
Definition
Tubes that connect cells together for the purpose of DNA transfer
Term
Cotransformation
Definition
Process in which two or more genes are transferred together during cell transformation
Term
non-reciprocal transfer
Definition
Gene transfer can only go from one cell to another, not the inverse
Term
Hfr cell
Definition
a cell will have an F plasmid integrated into the main chromosome; Can happen at many points along the chromosome, where there is a small amount of sequence that matches a part of the plasmid
Term
Hfr in Transformation
Definition
Transfer is usually incomplete; Pilus breaks down before whole chromosome transfers
Term
Lytic Cycle
Definition
Life cycle of a bacteriaphage in which phage genes are transcribed and translated, new phage particles are produced and the host cell is lysed.
Term
Lysogenic Cycle
Definition
Phage attachs to bacterial cell; Phage injects own genome into cell; Phage integrates its genome into bacterial chromosome; Phage DNA is copied with host DNA; Phage can “pull out” and go into lytic phase
Term
What type of information storage can be found in a virus?
Definition
Double or single stranded DNA or RNA
Term
Three genes typically found in a retrovirus
Definition
GAG, POL, ENV
Term
How do Viral Genomes save space?
Definition
Overlapping to make them into extremely small bodies.
Term
What type of storage material is found in a retrovirus?
Definition
RNA
Term
Reverse Transcriptase
Definition
reverse transcribes DNA into the eukaryotic genome.
Term
Where is Reverse Transcriptase produced?
Definition
The host cell
Term
Usage of Coinfection
Definition
Count the plaque phenotypes to determine loci distance.
Term
Deletion
Definition
Partial Chromosome loss
Term
Haploinsufficient
Definition
2 genes are required for proper expression.
Term
Aneuploidy
Definition
Having plus or minus a single chromosome.
Term
Trisomy
Definition
Three copies of one chromosome
Term
Aneuploidy
Definition
Very rare chromosome addition beyond trisomy.
Term
Aneuploidy usually caused by.........?
Definition
nondijunction
Term
polyploidy
Definition
Complete extra sets of chromosomes
Term
autopolyploid
Definition
Self-Doubling
Term
allopolyploid
Definition
sets from more than one species, due to hybridization
Term
Endomitosis
Definition
tissue specific increase of chromosome number by aborting cytokinesis
Term
Tissue-specific Chromosome Variation
Definition
Extra copies of genes are made where high levels of products or regeneration are needed.
Term
Robertsonian Translocations
Definition
Fuses two chromosomes near centromeres;
Begins as a reciprocal translocation of acrocentrics
Term
Polytene chromosomes
Definition
Chromosomes replicate without splitting, forming giant chromatids
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