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General Genetics
Chapter 12 from iGenetics, A Molecular Approach, 3rd edition, by Peter J. Russell
63
Biology
Undergraduate 4
11/10/2010

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Term
Diploid (2N)
Definition
A cell or and individual with 2 copies of each chromosome.
Term
zygote
Definition
The cell produced by the fusion of a male gamete (sperm cell) and a female gamete (egg cell).
Term
Haploid (N)
Definition
A cell or an individual with one copy of each nuclear chromosome.
Term
Genome
Definition
The complete compendium of genetic information in a haploid chromosome set.
Term
Homologous chromosomes
Definition
Chromosomes that have the same arrangement of genetic loci, are identical in their visible structure, and pair during meiosis.
Term
Homolog
Definition
Each individual member of a pair of homologous chromosomes.
Term
Nonhomologous chromosomes
Definition
Recombination between DNA sequences that are not identical or highly similar.
Term
Sex chromosomes
Definition
A chromosome in eukaryotic organisms that differs morphologically or in # in the 2 sexes. In many organisms, one sex possesses a pair of visibly different chromosomes. One is an X Chromosome, and the other is a Y chromomsome.
Term
Autosomes
Definition
A chromosome other than a sex chromosome.
Term
Centromere
Definition
A region of chromosome containing DNA sequences to which mitotic and meiotic spindle fibers attach. Under the microsope a centromere is seen as a constriction in the chromosome. The centromere region of each chromosome is responsible for the accurate segregation of replicated chromosomes to the daughter cells during mitosis and meiosis.
Term
Metacentric chromosome
Definition
A chromosome with the centromere near the center such that the chromosome arms are of about equal lengths.
Term
Sumbetacentric chromosomes
Definition
A chromosome with the centromere nearer one end than the other such that one arm is longer than the other.
Term
Acrocentric chromosomes
Definition
A chromosome with the centromere near one end such that it has one long arm plus a stalk and a satellite. (One long arm and a small bulge for the other arm)
Term
Telocentric chromosomes
Definition
A chromosome with the centromere more or less at one end such that only one arm is visible.
Term
Karyotype
Definition
A complete set of all the metaphase chromatid pairs in a cell.
Term
Mitosis
Definition
It is the process of nuclear division in haploid and diploid cells producing daughter nuclei that contain idnetical chromosome complements and to the parent nucleus from which they arose.
Term
Cell division
Definition
The process whereby one cell divides to produce two cells.
Term
Cell cycle
Definition
The cyclical process of growth and cellular reproduction in unicellular and multicellular eukaryotes. The cycle includes nuclear division (mitosis) and cell division (cytokinesis).
Term
G1 (gap 1)
Definition
The presynthesis stage of Interphase. The cell prepares for DNA and chromosome replication, which take place in the S stage.
Term
S
Definition
Synthesis phase of Interphase. When DNA and chromosomes are replicated.
Term
G2 (gap 2)
Definition
The postsynthesis stage of Interphase. The cell prepares for cell division which takes place in the M stage.
Term
M
Definition
This is Mitosis which happens once Interphase is over.
Term
Sister chromatids
Definition
Two identical copies of a chromosome derived from replication of the chromosome during interphase of the cell cycle. They are held together by the replicated but unseparated centromeres.
Term
Chromatid
Definition
One of the 2 vidibly distinct replicated copies of each chromosome that becomes visible between early prophase and metaphase of mitosis and is joined to its sister chromatied at their centromeres.
Term
Daughter chromosomes
Definition
Detached sister chromatids after they separate at the beginning of miotic anaphase or meiotic anaphase II.
Term
Interphase
Definition
Chromosome replication takes place during this. Following is mitosis.
Term
Prophase
Definition
The first stage in mitosis or meiosis during which the repicated chromosomes condense and become visible under the microscope.
Term
Prometaphase
Definition
Stage in mitosis in which the mitotic spendle has been forming between separating centriole pairs enters the former nuclear area, a kinetochore binds to each centromere and, kinetochore microtubules originating at one or other of the poles attach to each kinetochore.
Term
Kinetochore
Definition
Specialized multiprotein complex that assembles at the centromere of a chromatid and is the site of attachment of spendle microtubules during mitosis.
Term
Metaphase
Definition
The stage in mitosis or meiosis during which chromosomes become aligned along the equatorial plane of the spendle.
Term
Metaphase plate
Definition
The plane in the cell where the chromosomes become aligned during metaphase.
Term
Anaphase
Definition
The stage in mitosis when the sister chromatids separate and migrate toward the opposite poles of the cell.
Term
Telophase
Definition
The stage in mitosis or meiosis during which the migration of the daughter chromosomes to the two poles is completed.
Term
Cytokinesis
Definition
Division of the cytoplasm following mitosis or meiosis I or II during which the 2 new nuclei compartmentalize into separate daughter cells. (starts during the end of anaphase and ends after telophase.)
Term
What are the phases and order of the cell cycle? (there are 2)
Definition
Interphase then division
Term
What are the stages and order of the cell cycle? (there are 4)
Definition
1)G1 (gap 1)
2)S (synthesis)[this is when replication occurs]
3)G2 (gap 2)
4)M (mitosis) [this is when division occurs]
Term
What are the 5 stages of Mitosis in order?
Definition
1)Prophase
2)Prometaphase
3)Metaphase
4)Anaphase
5)Telophase
Term
Meiosis
Definition
Two successive nuclear divisions of a diploid nucleus, following one DNA replication, that results in the formation of haploid gametes or of spores having 1/2 the genetic material of the original cell.
Term
Gametogenesis
Definition
The formation of male and female gametes.
Term
Meiosis I
Definition
The first meiotic division, resulting in the reduction of the number of chromosomes from diploid to haploid.
Term
Prophase I
Definition
Stage in meiosis I in which the nucleoli disappear, the nuclear envelope breaks down, the meiotic spendle that has been forming between the separating centriole pairs enters the former nuclear area, a kinetochore binds to each centromere, and kinetochore microtubules originating at one or other of the poles attach to each kinetochore.
Term
Leptonema
Definition
The first stage in prophase I of meiosis during which the chromosomes begin to coil and become visible.
Term
Zygonema
Definition
The stage in prophase I of meiosis during which homologous chromosomes begin to pair in a highly specific way along their lengths.
Term
Synapsis
Definition
The intimate association of replicated homologous chromosomes brought about by the formation of a zipper-like structure (the synaptonomal complex) between the homologues during prophase I of meiosis.
Term
Synaptonemal complex
Definition
A complex structure that spans the region etween meiotically paired (synapsed) chromosomes and facilitates crossing-over.
Term
Pachynema
Definition
The stage in prophase I of meiosis during which the homologous pairs of chromosomes under crossing-over.
Term
Bivalent (tetrad)
Definition
A pair of homologous, synapsed chromosomes, consisting of 4 chromatids, during the first meiotic division.
Term
Crossing-over
Definition
The process of reciprocal chromosomal interchange that occurs frequently during meiosis and gives rise to recombinant chromosomes.
Term
Recombinant chromosome
Definition
A daughter chromosome that emerges from meiosis with an allele composition that differs from that of either parental chromosome.
Term
Genetic recombination
Definition
A process by which parents with different alleles give rise to progeny with genotypes that differ from either parent. (ex. parents with AB and ab genotypes can produce recombinant progeny with Ab and aB genotypes.)
Term
Diplonema
Definition
The stage in prophase I of meiosis during which the synaptonemal complex disassembles and homologous chromosomes begin to move apart.
Term
Chiasma
Definition
A cross-shaped structure formed during crossing-over and visible during the diplonema stage of meiosis.
Term
Diakinesis
Definition
The final stage in prophase I of meiosis, during which the replicated chromosomes (bivalents)are most condensed, the nuclear envelope breaks down, and the spendle begins to form.
Term
Prometaphase I
Definition
Stage in meiosis I in which the nucleoli disappear, the nuclear envelope breaks down, the meiotic spendle that has been forming between the separating centriole pairs enters the former nuclear area, a kinetochore binds to each centromere, and kinetochore microtubules originateing at one or other of the poles attach to each kinetochore.
Term
Metaphase I
Definition
The stage in meiosis I when each homologous chromosome pair (bivalent) becomes aligned on the equatorial plate.
Term
Anaphase I
Definition
The stage in meiosis I when the chromosomes in each bivalent separate and begin moving toward opposite poles of the cell.
Term
Telophase I
Definition
The stage in meiosis I, when chromosomes (each a sister chromatid pair) complete migration to the poles and new nuclear envelopes form around each set of replicated chromosomes.
Term
Meiosis II
Definition
The second meiotic division, resulting in the separation of the chromatids and formation of four haploid cells.
Term
Prophase II
Definition
The first stage of meiosis II during which the chromosomes condense.
Term
Prometaphase II
Definition
Stage in meiosis II in which the nuclear encelopes (if formed in telophase I) break down, the spindle organizes across the cell, and kinetochore microtubules from the opposite poles attach to the kinetochores of each chromosome.
Term
Metaphase II
Definition
The stage of meiosis II during which the chromosomes (each a sister chromatid pair) line up on the equatorial plate in each of the two daughter cells formed in meiosis I.
Term
Anaphase II
Definition
THe stage in meiosis II when the sister chromatids are pulled to the opposite poles of the cell.
Term
Telophase II
Definition
The last stage of meiosis II, During which a nuclear membrane forms around each set of daughter chromosomes and sytokinesis takes place.
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