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General Bio Chapter 10
Chapter 10
45
Biology
Undergraduate 1
09/09/2010

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Term
Chromosomes
Definition
major carriers of genetic information in eukaryotes
Term
Chromatin
Definition
Material consisting of DNA and associated proteins that make up chromosomes
Term
Genome
Definition
Entire collection of an organism's genes
Term
Human Genome Project
Definition
project that coded and examined the entire collection of genes found in humans
Term
Gene
Definition
hereditary sequences affecting some characteristics of an organism
Term
Histones
Definition
Proteins that facilitate chromosome packaging
Term
Nucleosome
Definition
Structure formed by positively charged histone and negatively charged DNA
Term
Scaffolding proteins
Definition
nonhistone proteins that help maintain chromosome structure
Term
Condesin
Definition
group of proteins required for chromosome compaction; bind to DNA and wrap it into coiled loops that are compacted into a chromsome
Term
Cell Cycle
Definition
the stages through which a cell passes from one cell division to the next
Term
M Phase
Definition
Phase in cell cycle involving mitosis and cytokinesis
Term
Interphase
Definition
the time when no cell division is occuring, most of cell's life in this phase
Term
1st Gap Phase (G1 Phase)
Definition
Phase that includes growth and normal metabolism, typically longest phase
Term
Synthesis Phase (S Phase)
Definition
Phase during which DNA replicates and histone proteins are synthesized so cells can make duplicates of its chromosomes
Term
Second Gap Phase (G2 Phase)
Definition
Phase that includes increased protein synthesis and final steps  in cell's preparation for division
Term
Mitosis
Definition
the nuclear division that produces two nuclei containing chromosomes identical to the parental nucleus
Term
Prophase
Definition
first stage of mitosis; begins with chromosome compaction and duplicated chromosomes become visible
Term
Sister Chromatids
Definition
pair of identical double stranded DNA sequences
Term
Centromere
Definition
center constricted region attaching sister chromatids
Term
Chosin
Definition
Ring shaped protein that physically links sister chromatids  along their arms and concentrated at the centromere
Term
Kinetochere
Definition
multiprotein complex to which microtubules bind
Term
Mitotic Spindle
Definition
formed by microtubules elongating from poles of the cell
Term
Microtubule-Organizing Center
Definition
region at poles of cell that microtubules extend from to form the miotic spindle
Term
Pericentriolar Material
Definition
consist of fibrils that surround the centrioles
Term
Prometaphase
Definition
when the nuclear encelope fragments, nucleolus disappears, and miotic spindle is completely assembled
Term
Metaphase
Definition
when duplicate chromosomes line up on the metaphase plate during metaphase
Term
Metaphase Plate
Definition
the midplane of the cell where duplicated chromosomes line up during metaphase
Term
Polar microtubules
Definition
extend from each ple to the equatorial region of the cell, where they generally lap
Term
Kinetochore microtubules
Definition
extend from each pole and attach to the kinetochores
Term
Karyotype
Definition
number and appearance of chromosomes in the nucleus of a eukaryotic cell
Term
Anaphase
Definition
sister chromatids separate and chromosomes move toward respective poles
Term
Telophase
Definition
Two separate nuclei form and conditions return to those of interphase
Term
Cytokinesis
Definition
the division of the cytoplasm to form two daughter cells
Term
Cleavage Furrow
Definition
formed by contractile ring in cytokinesis to form two separate daughter cells
Term
Cell Plate
Definition
partition formed in equatorial region of plant cells for the purpose of cytokinesis
Term
Binary Fission
Definition
process in which one prokaryotic cell reproduces asexually by dividing into two offspring cells
Term
Cell-cycle Checkpoints
Definition
Genetic signals in cell-cycle that ensure all events of a stage have been completed before the next stage begins
Term
Protein Kinases
Definition
enzymes that activate or inactivate other proteins by adding phosphate groups to them
Term
Cyclin-Dependent Kinases
Definition
protein kinases involve in controlling the cell cycle
Term
Cyclins
Definition
regulatory proteins that cyclin-dependent kinases bind to in order to become active
Term
Cyclin- Cdk Complex
Definition
when a specific cyclin-dependent kinase (Cdk) associates with a specific cyclin
Term
p27
Definition
protein known to be a major inhibitor of cell division
Term

Anaphase-promoting complex

(APC)

Definition
enzyme complex activated by M-Cdk at the end of metaphase
Term
Cytokinins
Definition
group of plant hormones that promotes mitosis both in normal growth and in wound healing
Term
Growth Factors
Definition
proteins which are active at extremely low concentrations and stimulate mitosis in some animal cells
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