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Gene Regulation in Bacteria
Genetics Analysis and Principles Chapter 14
29
Biology
Undergraduate 2
10/30/2011

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Term
gene regulation
Definition
phenomenon in which the level of gene expression can vary under different conditions
Term
constitutive genes
Definition
unregulated genes
Term
metabolism, response to environmental stress, cell division
Definition
processes commonly regulated on the genetic level
Term
transcriptional regulation
Definition
most common form of regulation in bacteria; regulation of the rate of this process
Term
repressor
Definition
regulatory protein that binds to the dna and inhibits transcription
Term
activator
Definition
regulatory protein that increases the rate of transcription
Term
negative control
Definition
transcriptional reg by a repressor
Term
positive control
Definition
regulation by an activator protein
Term
inducer
Definition
small effector molecule that causes transcription to increase
Term
inducible genes
Definition
genes that are up-regulated using an inducer
Term
corepressor
Definition
small molecule that bind to a repressor protein, causing it to bind to the DNA (lower rate)
Term
inhibitor
Definition
binds to an activator protein and prevents it from binding to the dna (lower rate)
Term
enzyme adaptation
Definition
particular enzyme appears with a living cell only after the cell has been exposed to the substrate for that enzyme
Term
operon
Definition
two or more genes under transcriptional control of a single promoter
Term
polycistronic rna
Definition
contains the sequences for two or more genes
Term
promoter
Definition
sequence that signals the beginning of transcription
Term
terminator
Definition
sequence that specifies the end of transcription
Term
CAP site
Definition
catabolite activator protein site; CAP binds in presence of cAMP (absence of glucose)
Term
operator
Definition
sequence that is binding site of repressor protein
Term
lacI gene
Definition
codes for the lac pressor; trans element
Term
allosteric regulation
Definition
small effector molecule binds to at least 2 allosteric sites to release repressor from operator
Term
merozygote
Definition
bacteria containing F' factor; a partial diploid.
Term
trans-effect
Definition
genetic regulation that can occur event though two pieces of dna are not adjacent
Term
cis-effect
Definition
regulation that can only have effect if the two pieces of dna are adjacent to one another
Term
catabolite repression
Definition
transcriptional regulation influenced by presence of glucose as it is broken down inside the cell
Term
ara operon
Definition
involved in arabinose metabolism;
Term
trp operon
Definition
involved in tryptophan production; repressible in presence of tryptophan
Term
attenuation
Definition
after transcription begins, selective stem-loop formation in the dna can facilitate termination
Term
posttranslational regulation
Definition
functional control of proteins that are already present in the cell
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