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GENE 302
Lecture 13 Sex Determination
13
Biology
Undergraduate 4
03/04/2012

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Term
In mammals, dosage compensation results from a type of
Definition
epigenetic regulation, in which all of the genes on one X chromosome are transcriptionally silenced
Term
Epigenetics
Definition
above or in addition to DNA sequence
Term
Epigenetic refers to
Definition
heritable changes in gene expression that are not due to changes in the DNA sequence itself
Term
The XIST gene product is a type of
Definition
non-coding RNA
Term
XIST RNA binds and coats to the
Definition
X chromosome it is transcribed from, and no other location in the genome
Term
TSIX is proposed to prevent XIST RNA from
Definition
causing inactivation of the other active X chromosome
Term
X-inactivation occurs in the
Definition
embryonic blastoderm
Term
The choice of chromosomes is random, but once an X chromosome is inactivated,
Definition
that designation is clonally inherited in all descendent cells
Term
Imprinting is
Definition
epigenetic silencing of specific chromosomal loci
Term
Inprint is transmitted from
Definition
one parent only (maternal vs paternal
Term
The net result in inprinting is
Definition
one of the two copies of target gene is silenced
Term
The imprint is erased in the what and reestablished in what?
Definition
Germline and gamete or zygote
Term
Usually paternally expressed genes does what to fetal growth and maternally expressed ones does what to fetal growth?
Definition
Enhance and Suppress
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