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G-protein-linked 2nd messengers
Pharm
13
Medical
Graduate
03/29/2013

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Cards

Term
alpha-1
Definition
Sympathetic
G-protein class - q
Inc smooth muscle contraction, inc pupillary dilator muscle contraction (mydriasis), inc intestinal and bladder sphincter muscle contraction
Term
alpha-2
Definition
Sympathetic
G-protein class - i
Dec sympathetic outflow, dec insulin release, dec lipolysis, inc platelet aggregation
Term
beta-1
Definition
Sympathetic
G-protein class - s
Inc HR, inc contractility, inc renin release, inc lipolysis
Term
beta-2
Definition
Sympathetic
G-protein class - s
vasodilation, bronchodilation, inc HR, inc contractility, inc lipolysis, inc insulin release, dec uterine tone (tocolysis), ciliary muscle relaxation, in aqueous humor produciton
Term
M1
Definition
Parasympathetic
G-protein class - q
CNS, enteric nervous system
Term
M2
Definition
Parasympathetic
G-protein class - i
Dec HR and contractility of atria
Term
M3
Definition
Parasympathetic
G-protein class - q
Inc exocrine gland secretions, inc gut peristalsis, inc bladder contraction, bronchoconstriction, inc pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation)
Term
D1
Definition
Dopamine
G-protein class - s
Relaxes renal vascular smooth muscle
Term
D2
Definition
Dopamine
G-protein class - i
Modulates transmitter release, especially in brain
Term
H1
Definition
Histamine
G-protein class - q
Inc nasal and bronchial mucus production, contraction of bronchioles, pruritus, and pain
Term
H2
Definition
Histamine
G-protein class - s
inc gastric acid secretion
Term
V1
Definition
Vasopressin
G-protein class - q
Inc vascular smooth muscle contraction
Term
V2
Definition
Vasopressin
G-protein class - s
Inc H2O permeability and reabsorption in the collecting tubules of the kidney
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