Term
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Definition
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Term
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Definition
| same as human insulin w/ 1 aa substitution pts can eat w/in 10 mins of administration TO: .25-1hr, D: 3-5hrs |
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Term
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Definition
same as human insulin w/ 1 aa transposition
more rapidly absorbed subcutaneously than human insulin
TO: .25-.5 hrs, D: 4-6hrs |
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Term
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Definition
soluble insulin
made with zinc
only type used i.v. (for life threatening hyperkalemia)
TO: .5-1hr, D: 6-10hrs |
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Term
| intermediate acting insulins |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
Slow onset long acting
Zn added -> precipitation at injection site and prolonged absorption
lente, ultralente, gargine, detemir |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
TDD of insulin = ?
day/night requirement |
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Definition
= 1/2 unt per kg ideal weight
day = 2/3 TDD
night = 1/3 TDD |
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Term
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Definition
estimates point drop of blood sugar in mg/dl per unit of Lispro or Aspart
1800/TDD = point drop (mg/dL) |
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Term
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Definition
same as 1800 rule but for regular insulin
1500/TDD = point drop (mg/dL) |
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Term
| glucose conversion mmol to mg/dL |
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Definition
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Term
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Definition
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Term
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Definition
BCR/ABL TK inhibitors - Imatinib, Dasitinib, Nilotinib
EGFR inhibitors - Gefitinib and Erlotinib |
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Term
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Definition
9-22 fusion product
ABL = tyrosine kinase gene on #9
BCR = break point cluster gene on #22 |
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Term
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Definition
tx for myelocytic leukemia (MCL)
blocks ATP binding site on BCR-ABL tyrosine kinase, preventing autophosphorylation and activation
Mut at T315l (imatinib binding domain) confers resistance to imatinib, dasitinib and nilotinib |
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Term
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Definition
EGFR inhibitor
Tx of non-small cell lung cancer
less nausea than previous chemotherapy |
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Term
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Definition
EGFR inhibitor
non-small cell lung cancer and pancreatic cancer |
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Term
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Definition
| Chimeric (mouse/human) monoclonal antibody against EGFR |
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Term
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Definition
Sunitinib, Sorafinib, Lapatinib
target multiple protein kinases |
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Term
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Definition
non-selective inib
targets many RTK |
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Term
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Definition
non-selective inib
targets many RTK |
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Term
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Definition
non-selective inib
targets many RTK |
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