Term
| Drug administration types |
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Definition
| Enteral (Oral, sublingual, subrectal), Parenteral (IV, intramuscular, subcutaneous, transdermal, intra osseous, intra rperitoneal, intra thecal, intra pulmonary: never HCO3- this way) |
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Term
| Most common way that drugs move across membranes |
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Definition
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Term
| drugs with a high first pass effect |
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Definition
| lidocaine, morphine, meperidine, aspirin, propranolol, verapamil, cyclosporine, amitriptylin, imipramin |
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Term
| Volume of distribution examples |
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Definition
| imipramine (2100, antidepressant that crosses blood brain barrier), lidocaine (80), Heparin (6: interferes with coagulation, stays in blood) |
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Term
| Volume of distribution formula |
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Definition
| Vd = Dose/C0 (Dose given, Concentration in blood initially) |
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Term
| Phase I and II metabolism are also known as? Where does it take place? |
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Definition
| oxidation (I), conjugation (II) in liver |
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Term
CYP450 metabolism of these drugs
-1A2
-3A4
-2C9
-2D6 |
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Definition
-Xanthines (1A2)
-Erythromycin (3A4)
-Phenytonin (2C9)
-Debrisoquine (2D6) |
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Term
|
Definition
| barbituates, carbamazepine, glucocorticoids, phenytoin, rifampin (orange color), St. John's wort |
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Term
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Definition
| cimetadine, nefazadone, grapefruit juice, azole antifungals, ciprofloxacin, erythromycin |
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Term
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Definition
| Clearance of drug/Clearance of creatinine (5 is highest, penicillin) |
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Term
| Organic Anion Transporter (used to secrete these substances into proximal tubules) |
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Definition
Endogenous: cAMP, PG, bile salts
Exogenous: penicillin, probenecid (boosts penicillin plasma levels) |
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Term
| Organic Cation Transporter (used to secrete these substances into proximal tubules) |
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Definition
Endogenous: Dopamine, norepinephrine, epinephrine, creatinine
Exogenous: cimetidine, ranitidine, morphine |
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Term
| Creatinine clearance formula (for renal impairment) |
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Definition
| CCr = (140-age)(weight in kg)/ (72 x Serum creatinine) 72 -> 84 in females, 0.8 to 1.4 mg/dL is normal. |
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Term
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Definition
Clearance = Vd * Ke
where Ke = (0.7/t1/2)
t1/2 is half life
Ke is the elimination constant |
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