Term
| what are the fnx of epithelia |
|
Definition
1.Barrier (protection) – covering & lining surfaces
protects underlying tissues
2.Secretion – mucus, hormones, enzymes, etc
3. Absorption – from lumen (intestine)
4. Transport - across an epithelium (respiratory ,
intestinal, and urinary layers)
5.Detection of sensations – to receive and transmit
stimuli, as in taste buds, retina of eye, and
hair cells in ear |
|
|
Term
| what is the basal lamina and what does it do |
|
Definition
basal lamina attaches the epithelium to cell membrane .
made of lamina densa and lamina lucida
it provides support, limits contacts, is a selective barrier |
|
|
Term
| compare lamina densa and lucida |
|
Definition
lamina lucida= mainly made of glycoproteins
laminin and entactin
transmembranes proteins=integrins
basement membrane =type 4 coll
Lamina densa
mainly made of proteoglycan perlacan and fibronectin
coll type 4
has the lamina reticularis (reticular fibers (coll 3)as well: fibronectin and fibroblast |
|
|
Term
| how is basal lamina attached to other structures |
|
Definition
Anchoring fibrils ( coll type 6)=>> to lamina reticularis
microfibrils=>> to elastic fibers |
|
|
Term
| disease caused by a mutation of coll 7 gene |
|
Definition
| dystrophic epidermolysis bullosa |
|
|
Term
| 3 types of simple tissues an where do we find them |
|
Definition
simple squamous: lining of BV and alveoli, bowmans' capsule
simple cubodal: kidney tubules, covering pvery, duct of glands
simple columnar: GI + gallblader |
|
|
Term
| pseudostratified columnar |
|
Definition
has 2 or more levels
respiratory tract with cilia and goblet cells
in epididymis with stereocilia |
|
|
Term
| stratified squamous, cuboidal and columnar |
|
Definition
squamous: esophagus and skin
cuboidal: duct of sweat gland and large duct of exocrine
columnar: duct of large glands |
|
|
Term
|
Definition
|
|
Term
| where do you find the 3 domains of a cell |
|
Definition
basal domain to the base of the membrane
(hemidesmosomes)
lateral domain on the side
(lamina densa and lucida)
(zona occludens> occludins and claudins zona adherens> E-cadherins)
(Mascula adherens=desmosome> desmocollins and desmogleins)
apical domain on top> stereocilia
|
|
|
Term
|
Definition
| results from hereditary defects of dynein ( absence of dynein arms) |
|
|
Term
|
Definition
endocrine>secretes its own product
exocrine> secretes its product via ducts |
|
|
Term
differentiate b/w
holocrine
merocrine
apocrine |
|
Definition
holocrine: rupture cell membrane and release its stuff
merocrine :exocitosis
apocrine: uses vesicle to release its stuff
|
|
|
Term
|
Definition
loose arrangement
groun substance
cells
coll type 1 |
|
|
Term
|
Definition
Dense reg: lots of Ground substance, less cells
ex: tendons ligaments and aponeuroses
Dense IRR: less ground substance and more cells
provides stremght
ex: submucosa of GI |
|
|
Term
|
Definition
3apolypeptide straight chain> tropocollagen> fibrils> fibers
need AA (gly, pro, hydropro) for synthesis |
|
|
Term
|
Definition
Type I –loose and dense C.T., bone, dentine
Type II – hyaline and elastic cartilage
Type III – reticular fibers
Type IV – basal lamina
Type V: placenta
Type VII: anchoring proteins in basal lamina
|
|
|
Term
| deficiency in hydrohyproline |
|
Definition
|
|
Term
|
Definition
support organs and tissue
coll type 3 |
|
|
Term
| difficiency in type 3 collagen |
|
Definition
ahlos-danlos syndrom
rupture of arteries, GI veryyyyy elastic skin |
|
|
Term
|
Definition
made of desmosine and idodesmosine with fibrillin
synthesis by AA GLY, PRO LYS
affected by light exposure |
|
|
Term
| whats is ground substance made of |
|
Definition
GAG,
proteoglycan ( hyaluronic acid)
glycoprotein branched
fnx: lubricant, barrier to microbes/virus, exchange gas |
|
|
Term
|
Definition
Fibroblast:from mesenchyme, they synthesize all 3 fibers and GS
PLasma cells:from b-lympho, they producce anti-body
MAcrophage:from monocytes, they phagocyte
Mast cells: from bone marrow, they r involved in inflammatory response and allergic rxn
Adipose cells:from mesenchyme, energy reserve
Mesenchymes cells:many potential |
|
|
Term
|
Definition
they have the IgE receptor
IgE is produced by plasma cell |
|
|
