Term
| gout is caused by what two things |
|
Definition
hyperuricemia
repeat attacks of acute arthrits |
|
|
Term
| acute arthitis attacks lead to deposits of |
|
Definition
| monosodium urate cyrstals |
|
|
Term
acute gouty arthritis shows in _
symtpoms peak _days
resolve _ days |
|
Definition
|
|
Term
| what type of gout shows kindey stones |
|
Definition
|
|
Term
| acute phase of gouty nephropathy has depositon of uric crystals where |
|
Definition
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|
Term
| chronic phase of gouty nephropathy has depositon of monosodium where |
|
Definition
|
|
Term
| what type of gout is deposits of monosodium in the soft tissues |
|
Definition
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|
Term
gout affect _%
hyperuricemia affects _% |
|
Definition
|
|
Term
what age is gout more commen?
what gender? |
|
Definition
|
|
Term
| increase in age correlates with rise in _ in males |
|
Definition
|
|
Term
| incidence in women rises after? |
|
Definition
|
|
Term
| what is teh edn product of purine degradation |
|
Definition
|
|
Term
| what enzyme converts to uric acid |
|
Definition
|
|
Term
| what is dominant species of uric acid in plasma |
|
Definition
|
|
Term
what are the factros for max solubility of monosodium urate:
mg/Dl
celcius
pH |
|
Definition
|
|
Term
| what enzyme do humans lack to convert uric acid to more soluble |
|
Definition
|
|
Term
| hyperuricemia is defined as serum urate > |
|
Definition
|
|
Term
Overproduction of Uric Acid:
> _ mg uric acid in urine-
does diet play a major role? |
|
Definition
|
|
Term
| uric acid can be over produced by inceased breakdown of |
|
Definition
|
|
Term
| uric acid can also be increased by what class of drugs |
|
Definition
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|
Term
overproduction of uric acid genetics is:
overactivity of _
deficiency in _ |
|
Definition
|
|
Term
| overactivity of PRPP synthetase causes increase production of |
|
Definition
|
|
Term
HGPRT converts hypoxanthine to _
and guanine to _ |
|
Definition
ionosine monoposphate
guanosine monophosphate |
|
|
Term
defect in HGPRT is a defect in what pathway?
causes increased (3 things)? |
|
Definition
purine salvage
guanine, hypoxanthine, uric acid |
|
|
Term
what is more apparanet
over production of urci acid
underexcretion of uric acid |
|
Definition
|
|
Term
| uric acid reabsoprtion is aided by |
|
Definition
| increased sodium retention |
|
|
Term
| hyperuricemia is associated with what things? (5) |
|
Definition
| male, obesity, BUN def, alcohol, lead |
|
|
Term
urate crystals are chemotactic to?
also activate? |
|
Definition
mononuclear leukocytes
complement |
|
|
Term
| what cells initate the inflammasone? |
|
Definition
|
|
Term
| the inflammasone releases |
|
Definition
|
|
Term
| IL-1b releases chemokines that attracts |
|
Definition
|
|
Term
| ending result of urate crystals phagocytosis in joints |
|
Definition
| vasodilation, heat, edema, pain |
|
|
Term
| acute gouty arthritis 3 characterisitics |
|
Definition
|
|
Term
acute gouty arthritis:
first attacks are _
and invovle the |
|
Definition
monoarticular
big toe-podagra |
|
|
Term
acute gouty arthritis begins in morning or night?
why? |
|
Definition
nigh
reabsorption of water from joint space |
|
|
Term
| what type of gout is seen more in uric acid overproducers? |
|
Definition
| uric acid nephroliathiasis |
|
|
Term
| acute gouty nephropathy is uric acid in what 2 things |
|
Definition
|
|
Term
| treatment classes for acute gout |
|
Definition
|
|
Term
| what are teh 3 NSAIDS that are FDA approved |
|
Definition
| naproxen, indomethacin, sulindac |
|
|
Term
| steroids admin intrarticular are limited to _ number of joints? |
|
Definition
|
|
Term
| intrarticular triamciniclone dose |
|
Definition
|
|
Term
what is the oral steroid?
IM? |
|
Definition
|
|
Term
| how mnay joints can systemic sterorids be used? |
|
Definition
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|
Term
colchicine is what class of drug?
causes deploarization of |
|
Definition
|
|
Term
colchicine blocks _
also inhibits migration of |
|
Definition
|
|
Term
| colchicine also affects rapid turning cells of what 2 things |
|
Definition
|
|
Term
| what are the xanthine oxidase inhibitors (blocks synth of urate) |
|
Definition
|
|
Term
| uricosuric agents? (increases excretion) |
|
Definition
| probenicid, sulfipyrazone |
|
|
Term
| recombinant urate oxidase (increases excretion) |
|
Definition
|
|
Term
| recombiannt uricase (increases excretion) |
|
Definition
|
|
Term
| brand name for allopurinal |
|
Definition
|
|
Term
| xanthine oxidase converrts allopurinol to _ the active form |
|
Definition
|
|
Term
| allopurinol can cause pancytopenia if admin with |
|
Definition
| azothiopurine or 6-mercaptopurine |
|
|
Term
| most common adverse affect of allopurinol? |
|
Definition
|
|
Term
| what xanthine oxidase inhibitor med doesnt need dose adj. for hepatic/renal impairment |
|
Definition
|
|
Term
| what prophylaxictic med is given parentarelly |
|
Definition
|
|
Term
| brand name for rasburicase |
|
Definition
|
|
Term
| uricase converts uric acid to |
|
Definition
|
|
Term
| brand name of pegloticase |
|
Definition
|
|
Term
most common adverse rxn of pegloticase?
others? |
|
Definition
n/v/d
anaphylaxis, gout flares |
|
|
Term
|
Definition
|
|
Term
MOA of probenecid it interferes with _
this prevents what? |
|
Definition
OAT
reabsorption of uric acid |
|
|
Term
| what med class should be given with probenecid |
|
Definition
|
|
Term
| probenecid reduces excretion of what other things? |
|
Definition
|
|
Term
| probenecid also prevents transport of acid compounds out of what? |
|
Definition
|
|
Term
| overdose of probenecid can cause |
|
Definition
|
|
Term
| whcih drug has antiplatelt activity- good for people with MI |
|
Definition
|
|
Term
| cant use sulinpyrazone with _ impairment |
|
Definition
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