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final
Unit 6 (miscellaneous viruses and such)
69
Microbiology
Undergraduate 1
07/23/2012

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Term
Teratogen
Definition
an agent that induces birth defects during embryonic development. Rubella and CMV.
Term
Viroid
Definition
Infection particles smaller than a virus. no capsid. single specific RNA. cause plant diseases.
Term
Prion
Definition
Proteinaceous infections particles. cause creuttzfeldt-jakob disease and kuru in humans. causes BSE in cows (mad cow disease)
Term
Virus families are given a name comprised of a Latin root followed by -viridae
Definition
Term
Picornaviridae
Definition
"small" "rna" "virus"

divided into 2 major groups: enteroviruses and rhinoviruses
Term
polioviruses
Definition
affinity for nervous tissue
transmitted in nose and throat discharges and in feces
subclinical -- no symptoms (95% of people affected never have symptoms)
4-6% -- nonparalytic poliomyelitis -- fever, stiffness or pain in the neck muscles
two types of vaccines: sabin - oral (100% effective) and salk -- 3 inner muscular infections (70-90% effective)
Term
hepatities A virus
Definition
mode of transmission is fecal-oral spread.
most cases result from close institutional contact, unhygienic food handling, shellfish, etc
affects liver
jaundice appears for 1-3 weeks.
recover is 2-6 weeks
Term
hepatitis E virus
Definition
mode of transmission is fecal-oral spread
disease similar to HAV, but pregnant women have high mortality rate
no vaccine
Term
foot and mouth disease virus
Definition
communicable disease of cloven hoofed animals (esp. cattle)
transmitted from cow to man and man to cow
Term
rhinoviruses
Definition
cause the common cold
spread by droplets, by discharges from the nose and throat, or freshly contaminated fomites (door handles, desks, etc)
confers immunity for that virus but there are 100 types.
Term
paramyeoviridae: rubella (german measles)
Definition
if occurs during pregnancy, causes severe fetal abnormalities
vaccination - MMR at 15 months of age
Term
paramyeoviridae: hep C (flaviviridae)
Definition
transmitted by infection of contaminated blood or body fluids
Term
paramyxoviridae: parainfluenzae virus
Definition
causes croup, bronchiolitis, pneumonia
Term
mumps virus
Definition
painful swelling of the parotid glands, although the salivary glands, testes, ovaries, and pancreas may be involved. in adults can manifest as orchitis.
epidemics are prevalent during winter months in schools and military personnel.
vaccine - MMR at 15 months age
Term
morbillivirus (red measles)
Definition
causes measles -- most common acute communicable disease affecting children.
vaccine: MMR at 15 months age
Term
pneumovirus: respiratory syncytial virus (RSV)
Definition
major cause of bronchiolitis and pneumonia in infants less than 1 year old
Term
rhabdoviridae: rabies virus
Definition
transmission occurs through infected animal bite
dogs, cats, bats, skunks
symptoms: severe headache, fever, depression and excitement
Term
orthomyxoviridae: influenzae virus
Definition
the flu
characterized by nasal discharge, headache, muscle pains, sore throat
synthetic drug, amantadine, can prevent and help cure influenza cause by A strains.
Term
reoviridae: rotavirus
Definition
intestinal viruses (gross diapers)
Term
retroviridae: retroviruses
Definition
enveloped, single-stranded RNA viruses with reverse transcriptase that converts the RNA into double stranded DNA.
oncogenic (cancer causing)
Term
human immunodeficiency virus (HIV types 1 and 2)
Definition
causes acquired immunodeficiency syndrome (AIDS)
HIV antibody positive state w/ some combo of infections, fever, weight loss, neoplasms, diarrhea, brain dysfunction
HIV originated in Africa
high mortality rate
in blood, semen, vaginal secretions
initial infections create flulike illness: virus becomes latent, brings levels of T helper cells down & invades brain
after incubation period of 2-15 yrs, infections occur including pneumocystis carini pneuymonia, serious diseases by protozoa, fungi, mycobacteria, and viruses
treatment: AZT
Term
HTLV I
Definition
human t lymphocyte virus I -- causes adult T cell leukemia or mycosis fungoides
fatal cancer
Term
HTLV II
Definition
causes hairy cell leukemia
high mortality rate
Term
herpesviridae
Definition
universal property of herpesviridae is latency.
remains in host cells, usually neorons, for long periods of time but can still replicate
Term
herpes simplex type 1
Definition
causes fever blisters and cold sores
treatment -- acylorvir (zovirax)
Term
herpes simplex type 2
Definition
after the lesion disappears, the vorus remains latent. recurrent genital herpes is frequent.
treatment: zovirax
Term
varicella-zoster
Definition
causes chicken pox.
causes shingles
Term
cystomegalovirus (CMV)
Definition
leading cause of birth defects.
occurs in AIDS patients and transplant recipients
Term
epstein barr virus
Definition
causes infections mononucleosis
causes burkett's lymphoma in African children
Term
poxviridae: orthppoxvirus
Definition
smallpox
Term
papovaviridae
Definition
papillomaviruses: cause warts. genital warts. wart morphology ranges from tiny, flat, inconspicuous bumps to giant, branching cauliflower-like masses called condylomata acuminata.
vaccination: gardasil. age 9-24
Term
parvoviridae: parvovirus
Definition
can surivive in soil for up to 2 years. causes fatal gastroenteritis in pups
in humans: rash that resembles a slapped cheek.
Term
Hepatities B
Definition
transmitted by transfusion of blood or blood products, syringes, saliva & sex
causes chronic liver disease
vaccine available
Term
Hepatitis D
Definition
transmitted parenteral (host must be coinfected w/ hep B)
Hep B vaccine is effective because coinfection is required.
Term
primary syphilis
Definition
open lesion/ sore that is painless. (chancre)
appear on genitalia 80% of time
heals after 3-6 weeks
diagnosed w/ darkfield microscopy
treatment: penicillin
Term
treponema pallidum
Definition
causative agent of syphilis.
cannot be cultured in lab.
humans are natural host and source.
Term
secondary syphilis
Definition
red or brown rash that breaks out on all skin surfaces
the MS department of health uses the rapid plasma reagin test for rapid detection of syphilis.
treatment: penicillin
Term
latent syphilis
Definition
bacteremia caused by treponema pallidum.
can last up to 20 years.
can cause blindness.
Term
tertiary syphilis
Definition
very severe complications
can result in cardiovascular syphilis, which can rupture aorta.
can move to brain (neurosyphilis)
Term
congenital syphilis
Definition
can pass from pregnant woman into placenta and be carried through fetal tissues.
can lead to spontaneous miscarriage or stillbirth.
children often have CNS problems.
Term
leptospira interrogans
Definition
most often acquired when organism comes into contact through abrasions and mucous membranes
can be found in the environment, esp. in water cnotamited fomthe urine and tissues of infected animals.
Term
thallus or colony (mold)
Definition
aerial mycelium + vegetative mycelium
Term
aerial mycelium
Definition
grow above agar surface.
reproductive.
Term
vegetative mycelium
Definition
grow below agar surface.
Term
hypha
Definition
singular. branches growing off of mycelium
Term
mold
Definition
reproduce by spores
Term
septum
Definition
division in hypha.
Term
yeasts
Definition
reproduce by budding
Term
blastospore
Definition
simple budding forms in which daughter cell is abstricted from mother cell
Term
chlamidospores
Definition
thick walled spores produced by rounding up & enlargement of terminal cells of hyphae.
round spore forms on end and breaks off.
Term
arthrospores
Definition
resulting from simple fragmentation of the mycelium in cylindrical or cask shaped thick walled spores
all the mycelia fragmitize.
lots of septae throughout.
whole spore breaks apart
Term
colony of mold
colony of yeast
Definition
mycelial cottony mass
resemble bacterial colonies
Term
conidia-spore
Definition
microconidia: small spore
macroconidia: large spore
Term
primary routes of entrance for agents of fungal disease
Definition
#1: respiratory
#2: cutaneous (skin)
Term
endothrix
Definition
dermatophyte invades hair shaft
Term
ectothrix
Definition
dermatophyte invades outisde hair
Term
superficial
Definition
just below skin
Term
subcutaneous
Definition
completely below skin
Term
systemic
Definition
throughout the body
Term
tinea capitis
Definition
ringworm of the scalp
Term
tinea pedis
Definition
foot (athletes foot)
Term
tinea corporis
Definition
body
Term
tinea barbae
Definition
beard
Term
tinea cruris
Definition
jock itch
Term
onchomycosis
Definition
nail infection
Term
microsproum audouinii
Definition
epidemic ringworm of the scalp in school age children.
transmits from man to man
Term
microspourum canis (canine)
Definition
causes tinea capitis and corporis with an erythemic (red) lesion.
pups and kitties
Term
trichophyton mentagrophytes
Definition
athlete's foot (jock itch)
Term
tinea versicolor
Definition
skin disease
superficial brownish scaly areas on light skinned persons
lighter areas on dark skin
causative agent: malasseziofurfur
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