Term
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Definition
IV, Liquid, Tabs, Suppositories
Low oral bioavailabiltiy 30-40%, primarily IV can do IM
Primarily phase II metabolism: glucoronidation at C3 and C6 OH groups
Half-Life = 4 hours |
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Term
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Definition
5x morphine potency
IV, liquid, IR trabs, ER tabs, suppositories: mainly an IV drug
Oral bioavailability 75%
Primarily phase II: glucoronidation at c3 and c6 OH groups.
Half life < 2 hours = short acting
HIGH RISK OF RESPIRATORY DEPRESSION |
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Term
| Oxycodone (Percocet, roxicet) |
|
Definition
same potency as IV morphine, stronger than oral.
NO IV FORMS
Oral bioavailability: 60-70%
Primarily Phase I metabolism
Half life: 4 hours
One of the most diverted and abused RX in US
ER tabs only for chronic |
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Term
| Hydrocodone (Vicodin, Lortab) |
|
Definition
50% morphine potency
NO IV or IM |
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Term
| Codeine (Tylenol III, Cough/Cold AC liquids) |
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Definition
10% potency of morphine.
NO IV OR IM
Weak/Poor choice
Poorly GI tolerated
Must metabolize |
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Term
| Tramadol (Ultram, Ryzolt) |
|
Definition
20% or less potency of Morphine
No IV form
Parent compound acts like an SNRI
Active metabolite throuch cyp3a4
About 1/3 of drug is renally eliminated unchanged
Oral bioavailability >70%
Half-life = 7-8 hours
Serotonin and seizure risk |
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Term
|
Definition
100x potency of morphine
No oral doses; better than 90% availability in dermal patches
Primarily phase 1: cyp3a4 to inactivate metabolites
Half-life <60 minutes (very short acting)
Big-guns, extremely active mu kappa delta agonist, use to get people out quickly
Huge risk for respitory |
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