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Fetal and Neonatal Circulation
Fetal and Neonatal circulation by Dr. Gibbons
20
Medical
Professional
10/05/2011

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Term
acts as a fetal lung during gestation of the fetus
Definition
the placenta
Term
where does exchange ooccur in fetal circulation?
Definition
the fetus circulation projects villi containing brances of the umbilical arteries and veins into a lake a maternal blood
Term
True/ false the fetal gas exchange is more efficient than lung gas exchange
Definition
False
Term
the umbilical arteries are equivalent to what artery that carries venous blood
Definition
the pulmonary artery
Term
the umbilical veins are equivalent to what vein that carries arterial blood
Definition
pulmonary vein
Term
Why is the PO2 gradient from maternal to fetal blood so large
Definition
its caused by the poor efficiency of diffusion
Term
how are PCO2 and pH gradients improved between the fetus and the maternal blood
Definition
maternal hyperventilation
Term
the 3 reasons that in spite the low fetal blood PO2 , the fetus has reasonable oxygen delivery
Definition
the HbF delivers oxygen more effectively that HbA
the fetus has higher RBC mass to promote oxygen delivery
the higher CO2 level in the fetus reduces the affinity of Hb for oxygen (promoted O2 delivery- Bohr effect)
Term
brings oxygenated blood from placenta to the heart bypassing the liver
Definition
ductus venosus
Term
Shunts oxygenated placental blood from the inferior vena cava through the right atria into the left atria
Definition
foramen ovale
Term
less oxygenated blood from the superior vena cava enters the right heart, pulmonary artery, and bypasses the lungs
Definition
ductus arteriosus
Term
what happens during the first fetal breath?
Definition
there is a very significant negative pressure, expanding the lugns and lowering the pulmonary vascular resistance to 20% of the fetal level.

COnversion to low pressure pulmonary and high pressure arterial promotes the closing of shunts
Term
humeral factor that plays a role in shunt closing
Definition
prostaglandins
Term
closes in 1-3 hours after birth, due to the closure of smooth muscle but the mechanism is poorly understood.
Definition
ductus venosus
Term
Decreased pulmonary vascular resistance lowers right atrial pressure and blood returning from the lungs raises pressure in left atrium, closes this shunt
Definition
foramen ovale
Term
this hormone constricts he umbilical vessels and the ductus arteriosis and dialates the pulmonary vessels
Definition
bradykinin
Term
this chemical keeps the ductus arteriosis open prior to birth and has a role in preventing pulmonary hypertension
Definition
ductus arteriosus
Term
All the oxygenated blood gets sent back to the lungs. the blood flows like normal until it gets to the aorta, then it shunted back to the pulmonary artery. results in enlargement of the left atria, left ventricle (because the heart must pump hard to bypass the shunt) and the aorta
Definition
patent ductus srteriosus
Term
there is a defect in the wall of the atria, so the blood flows from the left side into the right side of the heart. results in enlarged right atria, right ventricle, and pulmonary artery
Definition
atrial septal defect
aka
ostium secumdum type A
Term
there is defect in the cushion of the heart, causing blood from the left ventricle to be shunted to the right ventricle. this causes the left ventricle ans atria to enlarge
Definition
ventricular septal defect
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