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Fertilization
Biology 200 Lecture Notes
18
Biology
Undergraduate 2
07/27/2011

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Term
Lipid-Soluble Signals
Definition
1) Lipid-soluble (small, hydrophobic) signal diffuses across plasma membrane into cell.
2) Signal binds to receptor, inducing conformational change or binding to a carrier.
3) Complex binds to DNA, inducing a change in cell activity.
- No membrane proteins are required!
Term
Intermembrane Signal Receptors
Definition
1) Signal (ligand) is received.
2) Signal is transduced.
3) Signal is amplified.
4) Cell responds.
Term
Advantages of Fertilization in the Open Ocean
Definition
Cheap, long distance, synchronizable.
Term
Disadvantages of Fertilization in the Open Ocean
Definition
Low probability of success in massive expanse of water, many predators, confusion between species.
Term
To help the sperm find the egg
Definition
Egg releases a small 10-aa peptide 'resact;' resact diffuse from the egg into nearby water; sperm use this concentration gradient to guide towards egg.
Term
Sperm have two swim motions
Definition
When little or no ligand is binding to receptor, "turn." When more resact receptor is bound to ligand, "straight."
Term
Fertilization Sequence
Definition
1) Sperm contacts jelly layer.
2) Acrosomal reaction begins.
3) Digestion of jelly layer.
4) Binding to vitelline envelope.
5) Sperm lyses hole in vitelline envelope. Fusion of acrosomal process membrane and egg membrane.
6) Sperm nucleus and centriole enter egg. Sperm nucleus then fuses with egg nucleus.
Term
________ is exposed along the acrosomal process.
Definition
Bindin
Term
What does Bindin bind to?
Definition
The fertilizin receptor on the egg.
Term
What happens to the sperm if the sperm does not enter the egg?
Definition
Death.
Term
What happens to the egg if the sperm does not enter the egg?
Definition
Waiting...
Term
What happens to the sperm if 1 sperm enters?
Definition
Life!
Term
What happens to the egg if 1 sperm enters?
Definition
Life!
Term
What happens to the sperm if 2 sperm enter the egg?
Definition
Small, small chance of life.
Term
What happens to the egg if two sperm enter the egg?
Definition
Trisomy = dead, mostly.
Term
The Calcium Wave
Definition
1) Egg is covered with sperm. One sperm enters.
2) Fertilization envelope begins to lift and clear away excess sperm.
3) Fertilization envelope expands across egg.
4) Completed fertilization envelope has cleared away all excess sperm.
Term
Blocking polyspermy: Cortical Granules
Definition
Calcium wave causes cortical granules to fuse with egg plasma membrane; carbohydrates are released into the inter-layer space; this thick fluid absorbs water and swells, pushing away the vitelline envelope.
Term
Fast Block
Definition
Uses the change in membrane potential in the egg to help protect against a second sperm; change in membrane potential rapidly and temporarily distorts fertilizin structure; this inactivates all fertilizin molecules for about six seconds.
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