Term
Fentanyl Citrate (Sublimaze, Duragesic)
By what action does fentanyl work on the body? |
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Definition
Fentanyl works by effecting all the opioid receptors, but mainly Mu opioid receptors. These receptors cause a dependence and serve as the bodies natural "rewards" system
It has less emetic and vasodilatory effects than morphine
Exhibits little hypnotic activity and histamine release rarely occurs
Has 80 times the analgesic property of morphine |
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Term
Fentanyl Citrate
Name the class and schedule, as well as the popular side effects of drugs in this class |
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Definition
Class: Narcotic agonist; Opioid analgesic
Drugs in this class typically cause:
CNS: Dizziness (vertigo); drowsiness; delirium (AO X2); sedation; euphoria; mental clouding; lethargy; impairment of mental and physical performance; anxiety; fear; dysphoria; psychic dependence; mood changes
Cardiovascular: Circulatory depression; peripheral circulatory collapse and cardiac arrest following rapid administration; Orthostatic hypotension; Hypertension; Hypotension; Bradycardia: rapid administration may result in chest wall rigidity that will not respond to neuromuscular blockade
Respiratory: Apnea; Respiratory depression;
Gastrointestinal: Nausea; Vomiting; Constipation
Other: Miosis. (pupillary contraction) |
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Term
| Indication for the use of fentanyl citrate |
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Definition
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Term
Fentanyl Citrate
How long does it take for fentanyl citrate to have effect?
How long does this last?
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Definition
Onset of action: immediate 2 to 5 minutes
Duration of action: 30 minutes to 2 hours
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Term
Fentanyl Citrate
(Contraindications) |
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Definition
Absolute: Known hypersensitivity/allergy; shock; severe hemorhage; undiagnosed or suspected head or abd. pain; monoamine oxidase inibitors within prev. 14 days; Myasthenia gravis; use with caution with head injuries.
Relative: Active labor and delivery pain
- Isocarboxazid (Marplan)
- Phenelzine (Nardil)
- Selegiline (Emsam)
- Tranylcypromine (Parnate)
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Term
Fentanyl Citrate
Dosage: Adult and Pediatric
Route:
Preparations: |
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Definition
Adult dosage is between 2-3 mcg/2mL vial
Pediatric dosage: 1.7 to 3.3 mcg/kg (2 to 12 y/o)
Route: Slow IVP (FAST PUSH CAN CAUSE CARDIAC ARREST)
Preparations: 100mcg/2 mL
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Term
Is Fentanyl Citrate Safe for use in pregnant patients?
What main points should dominate your thinking with regards to fentanyl citrate? |
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Definition
It is Class C with regards to pregnancy safety.
Always pay attention to using fentanyl citrate in patients with the following:
- Head inury
- advanced age, COPD, bradydysrhythmias, severe pulmonary, renal or hepatic diseases
- Patients that have taken MAOI inhibitors in the last 14 days (causes hypertensive crisis)
- Patients that are on pentobarbital and/or thiopental
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