Term
| zidovudine, AZT, ZDV (retrovir) |
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Definition
| NRTI--pyrimidine nucleoside (HIV) |
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Term
|
Definition
| NRTI--purine nucleoside (HIV) --peripheral neuropathy |
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Term
|
Definition
| NRTI--pyrimidine nucleoside (HIV, Hepatitis B) --Hep B flare up |
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Term
|
Definition
| NRTI--nucleoside analogue (HIV) --severe hypersensitivity |
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Term
|
Definition
| NRTI--nucleoside analogue (HIV, Hepatitis B) --hyperpigmentation of palms and soles |
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Term
|
Definition
| NNRTI--nucleoTide (HIV, Hepatitis B) |
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Term
|
Definition
| NNRTI--non-nucleoside (HIV) --P450 metabolism |
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Term
|
Definition
| PI--modified peptide (HIV, boost concentration of other PI's) --P450 metabolism, circumoral & peripheral paresthesia |
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Term
|
Definition
| PI--modified peptide (HIV) --P450 metabolism, nephrolithiasis |
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Term
|
Definition
| PI--synthetic non-peptide (HIV) --P450 metabolism |
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Term
| atazanavir sulfate (reyataz) |
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Definition
| PI--modified peptide (HIV) --P450 metabolism |
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Term
| chloroquine (aralen) and hydroxychloroquine (plaquenil) |
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Definition
| blood schizonticide--inhibits plasmodium feeding (treatment/prophylaxis of malaria) |
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Term
|
Definition
| blood schizonticide--inhibits plasmodium feeding (chloroquine resistant malaria) --cinchonism, neuromuscular blockade, myocardial depression |
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Term
|
Definition
| blood schizonticide--inhibits plasmodium feeding (chloroquine resistant malaria) --cinchonism, neuromuscular blockade, myocardial depression |
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Term
|
Definition
| blood schizonticide--inhibits plasmodium feeding (treatment/prophylaxis of chloroquine resistant malaria, especially P. falciparum) --ataxia, psychotic rxns, seizures |
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Term
|
Definition
| blood schizonticide--generates free radicals (drug of choice for chloroquine resistant P. falciparum) |
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Term
|
Definition
| tissue schizonticide (P. vivax/ovale malarial treatment) --hemolytic anemia |
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Term
|
Definition
| folic acid antagonist--dihydrofolate reductase inhibitor (treatment/prophylaxis of chloroquine resistant P. falciparum) |
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Term
|
Definition
| folic acid antagonist--dihydrofolate reductase inhibitor (treatment/prophylaxis of chloroquine resistant P. falciparum) --not available in US |
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Term
| pyrimethamine + sulfadoxine (fansidar) |
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Definition
| dihydrofolate reductase inhibitor + PABA incorporation inhibitor (presumptive treatment of chloroquine resistant P. falciparum) |
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|
Term
| atovaquone + proguanil (malarone) |
|
Definition
| inhibits proton transport and dihydrofolate reductase (treatment/prophylaxis of chloroquine resistant P. falciparum) |
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Term
|
Definition
| tetracycline--inhibits protein synth. (treatment/prophylaxis of drug resistant malaria) --phototoxicity, teeth discoloration, no children under 8 or pregnant women |
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Term
|
Definition
| antihelminth--Inhibits microtubule polymerization & microtubule dependent glucose uptake (Pinworms, Asymptomatic round worms, Hookworm, Neurocysticercosis d/t Taenia solium (pork tapeworm)) |
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|
Term
| pyrantel (antiminth, pin-x) |
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Definition
| antihelminth--Activates cholinergic nicotinic-Rs in muscles of nematode leading to Paralysis of worm (Pinworm, Heavy infections round worms) |
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|
Term
| praziquantel (biltricide) |
|
Definition
| antihelminth--Induces muscle contraction then spastic paralysis, ↑ Ca2+ ion influx (cestodes ex: taenia's) |
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Term
|
Definition
| antiprotozoan--Binds intracellular macromolecules inhibiting DNA Synthesis (symptomatic amebiasis, Giardiasis, Trichomonas vaginalis, Anaerobic bacteria, C. Diff (+), B. fragilis (-)) |
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Term
|
Definition
| antiprotozoan (Asymptomatic carriers of Amebiasis (entamoeba histolytica)) --neurotoxic, optic neuritis |
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Term
|
Definition
| antiprotozoan--Inhibits protein synthesis, Binds 30S ribosomal unit (Asymptomatic carriers of Amebiasis, Cryptosporidiosis in AIDS pts) --aminoglycoside so nephrotoxic and ototoxic |
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Term
|
Definition
| antiprotozoan--Interferes w/ anaerobic energy metabolism, Inhibit pyruvate:ferredoxin 2-oxidoreductase (Giardiasis, Cryptosporidiosis in immunocompetent) |
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Term
| mechlorethamine (mustargen) |
|
Definition
| alkylating agent CCNS (hodgkins, lymphosarcoma, CLL) |
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|
Term
| cyclophosphamide (cytoxan) |
|
Definition
| alkylating agent CCNS (hodgkins, lymphoma, multiple myeloma, leukemia, adenocarcinoma of ovary, breast and lung, immunosuppresant) --activated in liver |
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Term
|
Definition
| alkylating agent CCNS (BRAIN TUMORS, hodgkins/non-hodgkins lymphoma, multiple myeloma) --lipid soluble |
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Term
|
Definition
| alkylating agent CCNS (metastatic TESTICULAR and ovarian tumors, advanced bladder and lung cancer) --platinum containing, NEPHROTOXIC, OTOTOXIC |
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Term
| methotrexate (rheumatrex) |
|
Definition
| antimetabolite folic acid analog CCS (leukemia, lymphoma, breast head neck carcinomas, osteosarcoma, bladder and gastric cancer, immunosuppresant, PSORIASIS, RA) |
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|
Term
| mercaptopurine (purinethol) |
|
Definition
| antimetabolite purine analog CCS (acute lymphatic, acute myelogenous, and central nervous system leukemia, immunosuppresant) |
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Term
|
Definition
| antimetabolite pyrimidine analog CCS on proliferating cells--thymidylate synthetase inhibitor (breast carcinoma, colon rectum stomach and pancreas cancers, immunosuppresant) |
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Term
|
Definition
| antimetabolite pyrimidine analog CCS (acute non-lymphocytic and lymphocytic leukemia, chronic myelocytic leukemia, meningeal leukemia, immunosuppresant) |
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Term
| daunorubicin hydrochloride (cerubidine) |
|
Definition
| anthracycline antibiotic--intercalates and binds DNA CCNS (acute nonlymphocytic leukemia and acute lymphocytic leukemia) --cardiotoxic |
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Term
| doxorubicin hydrochloride (adriamycin) |
|
Definition
| anthracycline antibiotic--intercalates and binds DNA CCNS (lymphoma, leukemia, hodgkins, breast ovary testicle thyroid lung gastric carcinomas) --cardiotoxic |
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Term
| vinblastine sulfate (velban) |
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Definition
| vinca alkaloid--distrupt mitotic spindle CCS M phase (hodgkins lymphoma, kaposis sarcoma, testicular bladder lung carcinomas, brain tumors) --neurotoxic |
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Term
| vincristine sulfate (vincasar PFS) |
|
Definition
| vinca alkaloid--distrupt mitotic spindle CCS M phase (acute leukemia, hodgkins/non-hodgkins lymphoma, breast carcinoma, bladder cancer) --neurotoxic |
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Term
|
Definition
| podophyllotoxin--topoisomerase inhibitor, DNA chain breaks CCS G2 phase (testicular gastric lung carinoma and leukemias) --alopecia |
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Term
|
Definition
| diterpene from taxus brevifolia--promotes microtubule assembly CCS G2 and M phase (metastatic ovarian and breast carcinoma, non-small cell lung carcinoma) --alopecia |
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Term
|
Definition
| glucocorticoid--binds cytosolic receptors and affect DNA, RNA and protein synth. CCS G1 phase, suppress lymphocytes and macrophages (breast carcinoma, leukemia and lymphoma, immunosuppresant) --iatrogenic cushings syndrome |
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Term
|
Definition
| nonsteroidal antiestrogen CCS G1 phase (BREAST cancer) --hot flashes, visual disturbances, hypercalcemia, vaginal bleeding, potential tumor promoting endometrial cancer |
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Term
| imatinib mesylate (gleevec) |
|
Definition
| kinase inhibitor--Bcr-Abl protein tyrosine kinase inhibition, inhibits cell proliferation and induces apoptosis, CCS G1 phase (PHILADELPHIA chromosome pos. chronic myeloid leukemia, ALL, c-Kit (CD117) receptor pos. gastrointestinal stromal tumor) --joint pain, fluid retention, cramps, edema, rash |
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Term
|
Definition
| IgG1 monoclonal AB--binds extracellular domain of human epidermal growth factor receptor HER-2, downregulation of EGF receptor tyrosine kinase signaling, G1 cell cycle arrest (BREAST cancer in EGF-2 pos. tumors) |
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Term
| chlorpromazine (throrazine) |
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Definition
| low potency phenothiazine--D2 antagonist (antipsychotic) --sedation, CV, AC effects |
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Term
| fluphenazine (prolixin, prolixin decanoate) |
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Definition
| high potency phenothiazine--D2 antagonist (antipsychotic) --EPS effects |
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Term
| prochlorperazine (compazine) |
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Definition
| high potency phenothiazine--D2 antagonist (antipsychotic, antiemetic) --EPS effects, |
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|
Term
| trifluoperazine (stelazine, suprazine) |
|
Definition
| high potency phenothiazine--D2 antagonist (antipsychotic) --EPS effects |
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|
Term
| haloperidol (haldol, haldol decanoate) |
|
Definition
| high potency NONphenothiazine--D2 antagonist (antipsychotic) --EPS effects |
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Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (2nd line therapy as antipsychotic) --grunulocytopenia, agranulocytosis, seizures, metabolic SE's |
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Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic) --AC effects, metabolic SE's |
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Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (widely used antipsychotic) --metabolic SE's |
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Term
|
Definition
| 2nd gen atypical antipsychotic--Partial AGONIST/ANTAGONIST at D2 and 5-HT1a (antipsychotic) |
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Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic) |
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Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic) |
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|
Term
| imipramine (tofranil, janimine) |
|
Definition
| tricyclic--inhibits reuptake of NE and 5HT (BED WETTING, pain, 2nd line tx for depression) --decreases BETA receptors, AC and CV effects |
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Term
|
Definition
| tricyclic--inhibits reuptake of NE and 5HT (pain, 2nd line tx for depression) --worst AC effects |
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Term
|
Definition
| SSRI (depression, OCD, anxiety, PMDD, bulimia, anorexia) --drug interactions |
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Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| SSRI (OCD, depression) --short half life, wt gain |
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Term
|
Definition
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|
Term
|
Definition
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|
Term
venlafaxine (effexor)
desvenlafaxine (pristiq) |
|
Definition
| SNRI--inhibits reuptake of NE, 5HT, and DA (depression, anxiety) --stimulant activity, decreased BETA receptors |
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Term
|
Definition
| SNRI--inhibits reuptake of NE, 5HT, and DA (depression, anxiety, NEUROPATHIC PAIN) --CV effects |
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Term
|
Definition
| 2nd gen antidepressant--inhibits reuptake of 5HT, also blocks 5HT-2 receptors (depression) --PRIAPISM, sedating |
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Term
|
Definition
| 2nd gen antidepressant--inhibits reuptake of 5HT, also blocks 5HT-2 receptors (depression) --PRIAPISM, sedating |
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Term
|
Definition
| 2nd gen antidepressant--inhibits DA reuptake (depression, nicotine/cocaine/amphetamine addictions) --SEIZURES |
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Term
|
Definition
| 2nd gen antidepressant--blocks presynaptic alpha-2 receptors, increasing NE and 5HT release (depression with anxiety) |
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Term
|
Definition
| selective NE reuptake inhibitor (ADHD) --decreases BETA receptors, INCREASED BP |
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Term
|
Definition
| MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma |
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|
Term
| tranylcypromine (parnate) |
|
Definition
| MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma |
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Term
|
Definition
| MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma |
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|
Term
| lithium carbonate (eskalith) |
|
Definition
| mood stabilizer--alters phosphoinositol pathway? (manic depressive disorders) --hypothyroidism, nephrotoxic, teratogenic, toxicity=drunkenness |
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|
Term
| valproic acid analogs (depakene/depakote) |
|
Definition
| antiepileptic (epilepsy, manic depressive disorders) |
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Term
|
Definition
| antiepileptic (epilepsy, manic depressive disorders) |
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Term
|
Definition
| antiepileptic (epilepsy, manic depressive disorders) |
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Term
|
Definition
| maybe acting on cannabinoid receptors in brain (recreational) --lipid soluble, suppresses immune fxn, decreased testosterone, teratogenic, amotivational syndrome, lung damage |
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Term
|
Definition
| (nausea and vomiting during chemo, prevention of wasting in AIDS, maybe useful in glaucoma and asthma) |
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Term
|
Definition
| salvinorin A--agonist at kappa opioid and D2 receptors (recreational hallucinogen) --criminalized in some states |
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Term
|
Definition
| opioid-like effect--agonist at mu-opioid receptors (self medicating for pain relief/abuse, controlling opioid withdrawal) --currently legal |
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