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Exam 4: DNA
DNA
21
Biology
Undergraduate 1
12/09/2009

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Term
Transformation
Definition
Bacterial Cells can take up DNA. The transfer of information
Term
DNA Structure
Definition

1.DNA is nucleic acid

2.Building blocks of DNA are nucleotides

 

Term
Nucleotides are composed of...
Definition

5-Carbon Sugar Deoxyribose

Phosphate Group

Nitrogenous Base

Term

Nucleotide Structure Components

 

Definition

Nitrogenous base attached to the 1'

Phosphate group attached to 5'

OH at the 3'

Term
Chargaff's Rule
Definition

A=T

C=G

Term
Phosphodiester Bond
Definition

Bond between adjacent nucleotides

5' to 3' orientation

Term
Helical Structure
Definition

Discovered by Franklin & Wilkins

Diameter of DNA is 2nm and makes complete turn of helix every 3.4nm

Term
Watson & Crick
Definition
found out that dna was double helix structure.
Term
Dna Polymerase
Definition

Class of enzymes that all synthesize dna from a pre-existing template

require primer and synthesize in 5' to 3'

Term
Replication Fork
Definition
The Y-Shaped end fo a growing replication bubble in a dna molecule undergoing replication
Term
Lagging Strand
Definition
Dna strand that must be synthesized discontinually because of the 5' to 3' directionality fo dna polymerase during replication, and antiparallel nature of DNA
Term
Leading Strand
Definition
The DNA strand that can be synthesized continuosly from the origin of replication
Term
RNA Primer
Definition
Sequence of about 10 RNA nucleotides complementary to unwound DNA that attatches to replication fork, the DNA polymerase uses the RNA primer as a starting point for addition of DNA nucleotides to form new DNA strand.
Term
Okazaki fragment
Definition
a short segment of DNA produced by discontinouos replication elongation in the 5' to 3' direction away from the replication (lagging strand)
Term
Telomeres
Definition
Repeated DNA sequence on the ends fo eukaryotic chromosomes
Term
Telomerase
Definition
Contains RNA region that is used as a template so a DNA primer can be produced
Term
Telomerase-Aging
Definition
As people age there is less telomere activity
Term
Telomerase-Cancer
Definition
Cancer cells have telomerase activity
Term
Thymine Dimer
Definition
Bond between adjacent thymines. A photolyase enzyme recognizes the damage and binds to dimer. The enzyme absorbs visible light and uses energy to cleave dimer
Term
Griffith's Experiment
Definition
Genetic Material can pass from one cell to another
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