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Exam 4
Pulmonary Parenchymal Dz
92
Veterinary Medicine
Professional
04/18/2017

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Term
What are the 5 kinds of pneumonia?
Definition
-aspiration
-bacterial
-fungal
-viral
-protozoal
Term
What are the general CS of pneumonia?
Definition
-cough
-tachypnea
-dyspnea
-hemoptysis
-cyanosis
-collapse
-lethargy
-anorexia
-fever
Term
Loss of physical defense in the lung parenchyma can lead to aspiration pneumonia. Give some examples?
Definition
-laryngea dz
-loss of consciousness
-tracheal hypoplasia
-ciliary dyskinesia
-force-feeding
Term
What are some examples of dz leading to aspiration pneumonia due to regurgitation or vomiting?
Definition
-megaesophagus
-esophagitis
-GI dz
Term
What are some CS of aspiration pneumonia?
Definition
-adventitial lung sounds: crackles > wheezes
-thoracic rads: alveolar pattern 2/ cranioventral distribution
Term
Are cats or dogs more commonly affected by bacterial pneumonia?
Definition
-dogs >> cats
Term
What are some issues that can predispose an animal to bacterial pneumonia?
Definition
-concurrent viral resp dz: distemper, influenza, parainfluenza
-other bacterial infection: periodontitis, sepsis
-immunosuppression
-environment: dense housing, poor ventilation, sanitation issues
Term
How do we treat aspiration pneumonia?
Definition
-O2 supplementation
abx
-nebulization/coupage
-/+ bronchodilator, N-acetylcysteine
Term
What are the top 4 etiologies behind fungal pneumonia?
Definition
-Histoplasma capsulatum
-Blastomyces dermatitidis
-Coccidioides immitis
-Cryptococcus neoformas
Term
Are cats or dogs more commonly affected by each of the following etiologies of fungal pneumonia:
a) histo
b) blasto
c) coccidioides
d) crypto
Definition
a) cat > dog
b) dog > cat
c) dog >> cat
d) cat >> dog
Term
Which organ systems does histo like?
Definition
-liver
-spleen
-eyes
-GI (dog)
-skin (cat_
-bone marrow (cat)
-bone/joints (cat)
Term
Which organ systems does blasto like?
Definition
-bone
-LN
-eyes
0brain
-skin
-nares
Term
Which organ systems does coccidiodes like?
Definition
-bone
-skin
-pericardium
Term
How do we diagnose fungal pneumonia?
Definition
-thoracic rads: structured/nodular interstitial most common & lymphadenopathy
-see organism on cytology or histo
-Ag Enzyme Immunoassay (EIA)
Term
How do we treat fungal pneumonia?
Definition
-Itraconazole or Fluconazole
-1m past CS/rad resolution & at least 6m total duration
Term
What are some common etiologies for viral pneumonia in dogs and cats?
Definition
Dogs: distemper, adenovirus type II, parainfluenza, influenza
-Cats: herpes, calicivirus
Term
What do we see on thoracic rads w/ viral pneumonia?
Definition
-diffuse interstitial lung pattern
-secondary bacterial pneumonia common
Term
How do we treat viral pneumonia?
Definition
-isolation
-as w/ bacterial pneumonia
-O2 supplementation & supportive care
Term
Increased vascular permeability causes non-cardiogenic pulmonary edema. What are some etiologies behind that?
Definition
-neurogenic: sizures, head trauma, electrocution
-ARDS/ALI: IMHA, pancreatitis, sepsis, shock, poly-trauma, blood transfusion, uremia, envenomation, pneumonia
-direct lung injury: O2 toxicity, smoke inhalation, near drowing, lung lobe torsion
Term
How do we treat non-cardiogenic pulmonary edema?
Definition
-treat underlying cause
-O2 supplementation
-low-dose Furosemide
Term
What is the etiology of radial nerve deficit?
Definition
-prolonged lateral recumbency on non-padded surfaces
-also: blunt trauma, humeral or radial fx
Term
What are the CS of radial nerve deficit?
Definition
-can't advance limb so it is dragged
-cannot extend carpus & digits
-weight bering only
-lsos of skin sensation cranial & lateral
Term
How do we treat radial nerve deficit?
Definition
-protect dorsum of digits
-splint carpus
-anti-inflamm
Term
What is prognosis of radial nerve deficit?
Definition
-variable
-good if treated early
-bad if due to humeral fx
Term
What are some common etiologies of femoral nerve deficit?
Definition
-dystocia: forced posterior delivery
-sudden overstratching: roping, falling
-pressure from abscess/hematoma
Term
What are some CS of femoral nerve deficit?
Definition
-constant flexion & collapse of limb: crouching stance
-dec or absent patellar reflex
-chronic lesions: quads atrophy, spntaneous patellar luxation (lat>med)
Term
HOw do we treat femoral nerve deficit?
Definition
-anti-inflamm
-stall rest
Term
What is prognosis of femoral nerve deficit?
Definition
-variable
Term
What is the etiology behind obturator nerve deficit?
Definition
-peripartum cow due to dystocia
Term
What are the CS of obturator nerve deficit?
Definition
-while walking: hopping gait
-at rest: severe abduction or splay legged
-SEVERE CASES: luxated hip or femur fx
-no cutaneous sensory deficits
-often combined w/ sciatic n deficit
Term
What are our major ddx for obturator nerve deficit?
Definition
-sciatic n deficit
-coxofemoral luxation
-femoral fracture
Term
How do we treat obturator nerve deficit?
Definition
-anti-inflamms
-hobbles
-if necessary: frequent rolling, sling, float tank
-time
Term
What is the etiology behind sciatic nerve deficit?
Definition
-calving paralysis: forced fetal extractions
-others: injections in young animals, prolonged lat recumbency, compression by mass, pelvic fracture
Term
What are the CS of sciatic nerve deficit?
Definition
-at rest: limb hanging behind animal, stifle is dropped & extended, foot constantly knuckling
-walking: limb jerked forward & upward, no skin sensation distal to stifle
-may be recumbent
-m atrophy if past 7d
Term
How do we treat sciatic nerve deficit?
Definition
-anti-inflamm
-float tank/sling
-rolling side to side
-hobbles
Term
Describe the distal division of the sciatic nerve.
Definition
-peroneal nerve: cranial
-tibial nerve: caudal
Term
What are the common etiologies for peroneal n deficit?
Definition
-trauma
-prolonged recumbency
-calving paralysis
Term
What are the CS of peroneal n deficit?
Definition
-flexed fetlock & pastern joint: knuckling
-hyperextended hock
-loss of craniolateral skin snsation
Term
What is the etiology behind tibial n deficit?
Definition
-irritant drug injected in caudal hind limb mm
-dog bit
Term
What are the CS of tibial n deficit?
Definition
-hock hyperflexion
-forward knuckling of fetlock
-asymmetric pelvis
-loss of caudomedial skin sensation
Term
What is the etiology behind enterotoxemia aka overeating dz?
Definition
-Clostridium perfringens type D
Term
Briefly describe the pathophys of overeating dz.
Definition
-high CHO diet
-inc bacterial proliferation = epsilon toxin
-inc vascular perm = cerebral edema
Term
Which animals are most commonly affected by overeating dz?
Definition
-labs ? calves > adult sheep/goat
Term
What are the CS of enterotoxemia?
Definition
-dullness, ataxia, blindness, convulsion
-acute death
Term
How do we diagnose enterotoxemia?
Definition
-acute death
-rapidly growing animal
-grain diet
-glucosuria
Term
How do we treat enterotoxemia?
Definition
-usually not rewarding
-procaine penicillin
-antitoxin
Term
How do we prevent enterotoxemia?
Definition
-toxoid
Term
What kind of virus is Caprine Arthritis Encephalitis?
Definition
-retrovirus-lentivirus
Term
How is CAE transmitted?
Definition
-ingestion of CAE infected colostrum/milk
-others: direct contact, in utero, horizontal transmission, venereal transmission
Term
What are the CS of CAE?
Definition
-goat kids: 2-6m
-progressive ascending ataxia, tremors
-opisthotonos,, death
-in herd: see other syndromes, arthirits, pneumonia, mastitis, wt loss
Term
What are our major ddx for CAE?
Definition
-listeriosis
-Chlamydophila/Mycoplasma
-spinal trauma/abscess/parasite migration
Term
How do we diagnose CAE?
Definition
-AGID on blood for Ab (presuckle titer would be preferred)
-CSF tap: pleocytosis, inc protein
-PM: leukoencephalomyeltiis
Term
How do we treat CAE?
Definition
-culling
Term
How do we control CAE?
Definition
-colostrum management: remove kids from infected dam before nursing
& feed heat-treated colostrum
-possibly keep two herds
Term
What is the common name for Border Dz?
Definition
-hairy shaker lamb
Term
What is the etiology behind Border dz?
Definition
-pestivirus
-in utero infection w/ NC virus in ewe <50d of gestation
Term
What are the CS of Border Dz?
Definition
-lambs: hirsutism, tramors of head & neck, ataxia
-flock: abortion, infertility, birth defect
Term
How do we dx border dz?
Definition
-viral Ab in tissue, serology
Term
What do we see on PM lamb w/ border dz?
Definition
-hydranencephaly
-cerebellar hypoplasia
Term
What is the etiology behind Scrapie?
Definition
-prion
Term
How is Scrapie transmitted?
Definition
-vertical
-horizontal
Term
Which animals are affected by Scrapie?
Definition
-genetic susceptiblity
-Sheep (Suffolk) > goat
Term
What is the incubation period of Scrapie?
Definition
-1-7h
Term
What are the CS in sheep w/ Scrapie?
Definition
-behavioral changes
-tremors, ataxia
-nibbling reflex
-wt loss w/ same appetitie
-recumbency & death
Term
What are the CS in goats w/ Scrapie?
Definition
-same as sheep + regurge
-wt loss is uncommon
Term
What are some ddx for Scrapie?
Definition
-oveine progressive pneumonia
-internal caseous lymphadenitis
-etc
Term
How do we diagnose scrapie?
Definition
-CS
-third eyelid biopsy + stain
-genotype
Term
What do we see on PM w/ Scrapie?
Definition
-histopath: vacuolation of gray matter neuropil
-ihc = GOLD STANDARD
-western blot
Term
How do we treat Scrapie?
Definition
-don't
Term
How do we prevent Scrapie?
Definition
-genotype testing
Term
Describe the signalment of idiopathic pulmonary fibrosis (IPF).
Definition
-dog >> cat
-WHWT, Cairn terrier, Staffordshire bull terrier
-middle aged to older
Term
What are the CS of Idiopathic Pulmonary Fibrosis (IPF)?
Definition
-couch
0exercise intolerance
-tachypnea, dyspnea, cyanosis
-loud fine inspiratory crackles
Term
How do we diagnose Idiopathic PUlmonary Fibrosis?
Definition
-thoracic rads: diffus interstitial lung pattern
-thoracic CT: honey comb appearance
-signalment + CS + crackles - alveolar pattern = highly suspicious
-definitive diagnosis = lung biopsy
Term
How do we treat Idiopathic PUlmonary Fibrosis?
Definition
-antitussives: hydrocodone or butorphanol
-Sildenafil w/ pulmonary hypertension
-Corticosteroids: anti-inflamm
-bronchodilators d/c if no response w/in 1w
Term
How do we noninvasively screen Idiopathic Pulmonary Fibrosis cases for pulmonary hypertension?
Definition
-echo
Term
Is pulmonary neoplasia more commonly metastatic or primary?
Definition
-metastatic
Term
Is pulmonary neoplasia more common in cats or dogs?
Definition
-dog > cat
Term
What are some of the more common pulmonary metastatic neoplasias?
Definition
-melanoma (oral/digit)
-mammary tumor
-OSA
-thyroid carcinoma
Term
What are some of the more common multisystemic cancers that affect the lungs?
Definition
-lymphoma
-malignant
-histiocytosis
Term
What are some of the more common primary lung tumors? Are they usually benign or malignant?
Definition
-carcinoma > sarcoma
-commonly malignant
Term
HOw do we diagnose pulmonary neoplasia?
Definition
-rads + cytology/histo
-aspriate, biopsy, pleural fluid, airway sample
-Thoracic U/S: guide aspirate or biopsy
-thoracic CT: more sensitive for nodules, sx planning, guide aspirate/biopsy
Term
How do we treat metastatic pulmonary neoplasia?
Definition
-tx primary cancer
-sx resection if possible
Term
How do we treat primary pulmonary neoplasia?
Definition
-sx resection
-radiation
Term
How do we treat lymphoma or malignant histiocytosis in the lungs?
Definition
-chemotherapy
Term
HOw do we treat a dog w/ oral melanoma that has met to the lungs?
Definition
-tyrosinase vx after resection of oral melanoma
Term
What are the breeds predisposed to eosinophilic bronchopneumopathy?
Definition
-Huskies, Alaskan malaute, rotties
Term
What are the CS of eosinophilic bronchopneumopathy?
Definition
-cough
-tachypnea
-dyspnea
-exercise intolerance
-fever
-lethargy
-anorexia
-general malaise
Term
What causes eosinophilic bronchpneumopathy?
Definition
-idiopathic but likely immune0-mediated
Term
How do we diagnose esoniphilic bornchopneumopathy?
Definition
-adventitial sounds: crackles > wheezes
-thoracic radS: diffuse interstitial lung pattern
-50% have peripheral eosniphilia
-bronchoscopy & airway wahs: eosinophilia on cytology
Term
What are our major rule-outs for eosinphilic bronchopneumopathy?
Definition
-parasites
-HW
-fungal
-neoplasia
Term
How do we treat eosinpholic bronchopneumopathy?
Definition
-pred: start high then taper
-supportive care
-O2 supplementation
Term
What is the prognosis of eosinphilic bronchopneumopathy?
Definition
-excellent
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