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Exam 4
Chapters 19, 43
49
Biology
Undergraduate 1
04/14/2011

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Term
Small, infectious particles that consist of nucleic acid enclosed in a protein coat and, in some cases, a membraneous envelope
Definition
Virus
Term
You have isolated perticles from a patient, but are not sure wheter they have a viral envelope. The presence of which class of biological molecules would allow you to distinguish b/w the 2 types of virus?
Definition
phospholipids
Term
The viral gene contains __ - ___ genes
Definition
4-1000
Term
The protein shell that encloses the viral genome
Definition
capsid
Term
Capsids are built from ___________
Definition
capsomeres
Term
____________, which are derived from the host cell's membrane, contain a combo of viral and host cell molecules
Definition
viral envelopes
Term
Viruses that infect bacteria
Definition
(bacterio)phages
Term
Once a viral genome enters a host cell it begins to manufacture ______________
Definition
viral proteins
Term
A phage that reproduces only by the lytic cycle is called a _______________
Definition
virulent phage
Term
Three ways that bacteria protect themselves from phages
Definition
1/ loss of receptors that phages recognize
2. Use of restriction enzymes that cut up certain phage DNA
3. Bac are not always killed by the phage
Term
Phages that use both the lytic and lymphatic cycles are called ________________
Definition
temperate phages
Term
Adenovirus, Papvavirus, Herpesvirus, Poxvirus
Definition
Double-Stranded DNA
Term
Parvovirus
Definition
Single-stranded DNA
Term
Reovirus
Definition
Dbl-Stranded RNA
Term
Picornavirus
Definition
Single-stranded RNA
Term
Two key variables used to classify viruses that infect animals?
Definition
1. DNA or RNA
2. single-stranded or double-stranded
Term
Class IV
Definition
Genome serves directly as an mRNA and is translated immedietly after infection
Term
Class V
Definition
genome serves as a template for mRNA synthesis
Term
Class VI
Definition
Retroviruses: viruses include a gene called reverse transcriptase to copy their RNA genome into DNA (HIV)
Term
The viral DNA that is integrated into the host genome is called a _________
Definition
provirus
Term
Circular DNA in bacteria and yeasts
Definition
plasmids
Term
A double-stranded DNA virus, the largest virus yet discovered
Definition
mimivirus
Term
____________ are harmless derivitives of pathogenic microbes that stimulate the immune system to mount defenses against the actual pathogen
Definition
Vaccines
Term
People with nonfunctional chemokine membrane receptors on their helper T cells as a result of a genetic mutation are immune to HIV infection. Why?
Definition
HIV cannot enter the host cell
Term
____________ are circular RNA molecules that can infect plants and disrupt their growth.
Definition
Viroids
Term
________ are slow-acting, virtually indestructible infectious proteins that cause brain diseases in mammals
Definition
Prions
Term
The 3 Rs of the Immune System
Definition
Reconnaissance, Recognition, and Response
Term
_____________ immunity consists of external barriers plus internal cellular and chemical defenses
Definition
innate
Term
__________ immunity dvlps after exposure to agents such as microbes, toxins, or other foreign body substances
Definition
acquired immunity
Term
Vertebrates/Invertabrates (pick one) have acquired immune systems
Definition
Vertebrates
Term
The digestive system is protected by low ____ and _________, an enzyme that digests microbial cell walls
Definition
pH, lysozyme
Term
__________ circulate within hemolymph and carry out phagocytosis (ingestion of foreign substances, including bac)
Definition
Hemocytes
Term
_____________________ secrete antimicrobial peptides that disrupt the plasma membranes of bacteria
Definition
hemocytes
Term
Innate denfenses include ____________, ___________, and ___________________
Definition
barrier defenses, phagocytosis, antimicrobial peptides
Term
2 addtl defenses that are unique to vertebrates?
Definition
imflammatory response and natural killer cells
Term
Barrier defenses include __________________
Definition
skin and mucuous defenses of the respiratory, urinary, and reproductive tracts
Term
Groups of pathogens are recognized by _____________________
Definition
TLR, Toll-like receptors
Term
__________________ engulf and destroy microbes
Definition
Neutrophils
Term
__________________ are part of the lymphatic system and are found throughout the body
Definition
Macrophages
Term
________________ discharge destructive enzymes
Definition
Eosinophils
Term
________________ cells stimulate development of acquired immunity
Definition
Dendritic
Term
Peptides and proteins function in innate defense by attacking microbes directly or impeding their ___________
Definition
reproduction
Term
__________ proteins provide innate defense against viruses and help activate macrophages
Definition
interferon
Term
About __ proteins make up the complement system, which causes ____ of invading cells and helps trigger imflammation
Definition
complement, lysis
Term
Following an injury ________ cells release histamine, which promotes changes in blood vessels, this is part of the imflammatory response
Definition
mast
Term
Fever is a systemic imflammmatory response triggered by __________ released by macrophages, and toxins from pathogens
Definition
pyrogens
Term
______________ is a life-threatening condition caused by an overwhelmig imflammatory response
Definition
septic shock
Term
Natural killer cells attack damaged cells that no longer contain the _____ protein on their surface
Definition
MHC
Term
What is one way that pathogens avoid destruction?
Definition
modifying their surface to prevent recognition or by resisting breakdown following phhagocytosis (ex/ tuberculosis)
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