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Exam 3
Cell Bio
44
Biology
Undergraduate 2
11/11/2011

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Term
DNA binding protein(s) that help configure the replicated chromosome for segregation
Definition
Cohesins & Condesins
Term
part of the chromatids kinetochores attach
Definition
Centromeres
Term
contractile ring that is involved in cytokinesis is made up of
Definition
Actin & Myosin
Term
complex that degrades ubiquinated proteins is known
Definition
Proteasome
Term
From 1 diploid somatic cell how many sex cells can be produced from meiosis
Definition
4
Term
diploid cell contains two pairs of homologous chromosomes heterozygous for a pair of alleles, Aa and Bb respect how many different combinations of these alleles could be produced in the haploid daughter cells
Definition
4
Term
major difference between mitosis and meiosis
Definition
Homologous chromosomes associate only in meiosis.
Term
which stage of meiosis do chromatids separate completely
Definition
Anaphase II
Term
genotype of a human zygote will differ from that of both parents. Which of the following does not contribute to this variation
Definition
Presence of dominant genes
Term
Which occurs in G2 to M-phase

Assembly of the mitotic spindle
Nuclear membrane breakdown
Chromosome condensation
Activation of APC (anaphase promoting complex)
Definition
All of these
Term
Kinetochore microtubules of sister chromatids point in the same direction when
Definition
During meiosis I
Term
During anaphase, interpolar microtubules_______and kinetochore microtubules_______.
Definition
Lengthen, shorten
Term
a method used to ensure that the cell cycle proceeds in a forward direction

Destruction of cyclin and inhibitors at appropriate times in the cell cycle Phosphorylation/dephosphorylation of CDK
Inhibitors of CDK
Definition
All of the above
Term
Which checkpoint does the RB tumor suppressor protein affect
Definition
G1 to S
Term
When RB is phosphorylated
Definition
RB is in the inactive conformation
Term
P16 is a negative regulator of the cell cycle that
Definition
Inhibits the activity of CDK/cyclin
Term
Cells respond to mitogenic signals during:
Definition
G1 phase
Term
P53 is a functional transcription factor when
Definition
It is phosphorylated
Term
What happened when Rao and Johnston fused a G1 and S phase cell
Definition
The hybrid cell contained two S phase nuclei.
Term
Which of the following occurs during PCD (Programmed Cell Death)

Loss of cell volume
Nuclear condensation
Cleavage of actin and lamin
Chromatin destruction
Definition
All of the above
Term
Which of the following class of proteins mediates cleavage of cellular targets
Definition
Effector proteins
Term
Injection of cytochrome C directly into the cytoplasm of a mammalian cell will result in
Definition
Activation of the caspase cascade
Term
Which of the following would be located in the cytosol

Bcl-2 like proteins
Apaf1 (adaptor) protein
Procaspase proteins
A and B
B and C
Definition
B and C
Term
Which of the following is a cell junction in plant cells

Gap junction Hemidesmosome
Desmosome
Plasmodesmata
BandC
Definition
Plasmodesmata
Term
Epithelial cells are connected to the Extracellular Matrix (ECM) via
Definition
Fibronectin
Term
Which protein is located in the cytoplasm
Definition
Actin
Term
Which of the following cell types is found in the human tongue
Definition
Stratified squamous epithelium
Term
The basal lamina is connected to, by,
Definition
Intermediate filaments, hemidesmosomes
Term
Procollagen is converted to mature collagen:

a.In the cytoplasm
b.In the ER
c.In the extracellular environment
d.By proteolytic cleavage
e. C and D
Definition
e. C and D
Term
Which cell type has the least plasticity
Definition
Dividing precursor cells
Term
Which cell type is not capable of cellular division
Definition
b. Myotubes
c. Myofibers
Term
Which of the following types of problems may be caused by defects in gap junctions
Definition
Deafnessv
Term
Which statement is false
Definition
Collagen is synthesized in its mature form by fibroblasts.
Term
The neural tube is formed during the process of early embryonic development. Which structure is most directly involved in this process
Definition
Adherens junctions
Term
Which of the following mutations is likely to induce cell-cycle progression?
Definition
A mutation in a cell-surface mitogen receptor that made it active even in the absence of its mitogen ligand
Term
During mitosis, sister chromatids are held together by ________ which is rapidly degraded during the transition to __________
Definition
Cohesin, anaphase
Term
Which events occur during interphase
Definition
DNA replication
Term
Microtubules attach to kinetochores.
Definition
as soon as the nuclear envelope breaks down
Term
Kinetochore microtubules of sister chromatids point in the opposite direction

A.During meiosis I
B.During meiosis II
C.During mitosis
D. A and B
E. B and C
Definition
E. B and C
Term
Which DNA-binding protein is active when phosphorylated

A. RB
B. E2F
C. P53
D. Mitotic-Cyclin-dependent Kinase complex
E. P16
Definition
B. E2F
Term
When the RB protein is phosphorylated
Definition
E2F is activated
Term
Overexpression of the p16 protein will most likely
Definition
Have an anti-growth effect on the cell
Term
During meiosis, when does the precursor germ cell become haploid
Definition
Metaphase II
Term
When do homologous chromosomes “find” each other?
Definition
Before they line up on the metaphase plate
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