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Exam 2 Microbiology
Exam 2
85
Microbiology
Undergraduate 2
08/07/2013

Additional Microbiology Flashcards

 


 

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Term
Bacteriophage (phage)
Definition
A virus that infects bacteria.
Term
Virus
Definition
A submicroscopic, parasitic, filterable agent consisting of a nucleic acid surrounded by a protein coat.
Term
Prion
Definition
An infectious protein particle
Term
Examples of Prions
Definition
Kuru, Scrapie, Mad cow disease, Cruetzfeld-Jakob disease, Gertsman-Straussler Syndrome and fatal familial insomnia
Term
Complex virus
Definition
Any virus that has additional structures (like feet)
Term
Lysogeny –
Definition
State in which phage DNA is incorporated into the host cell without lysis.
Term
Lytic
Definition
Phage multiplication that results in host cell lysis/death.
Term
Fomite
Definition
A nonliving object that can spread infection.
Term
Acute infection
Definition
An infection in which symptoms develop rapidly but last for only a short time.
Term
Inapparent infection
Definition
An infection that does not cause a noticeable illness (subclinical) CARRIER
Term
Chronic infection
Definition
An illness that develops slowly and is likely to continue or recur for long periods.
Term
Primary infection
Definition
Acute infection that causes the initial infection
Term
Secondary infection
Definition
An infection caused by an opportunistic microbe after a primary infection has weakened the host’s defenses.
Term
Persistent infection
Definition
A disease process that gradually builds up and progresses over a period of time.
Term
Epidemiology
Definition
The science that studies when and where diseases occur and how they are transmitted.
Term
Symptom
Definition
A change in body function that is FELT by the patient as a result of disease SUBJECTIVE
Term
Sign
Definition
A change due to a disease that can be OBSERVED or MEASURED
Term
Incidence
Definition
Fraction of a population that contracts a disease during a particular period of time.
Term
Endemic
Definition
A disease that is constantly present in the population
Term
Pandemic
Definition
Epidemic disease that occurs worldwide.
Term
Epidemic
Definition
A disease acquired my many hosts in a given area in a short period of time.
Term
Endotoxin
Definition
Part of the outer portion of the cell wall (Lipid A) of most Gram-negative bacteria; released on destruction of the cell.
Term
Innate immunity
Definition
Host defenses that afford protection against of any kind of pathogen.
Term
Margination
Definition
The process by which phagocytes stick to the lining of blood vessels.
Term
Diapedesis
Definition
The process by which phagocytes move out of blood.
Term
What bacteria normally live in the human intestine?
Definition
Escherichia coli, Fusobacterium, Lactobacillus, Enterococcus, Enterobacter, Proteus, Candida(fungus), Clostridium difficile. Facultative anaerobes, aerotolerant anaerobes.
Term
What food products does Lactobacillus aid us in making?
Definition
Cheese, yogurt, rye bread, sauerkraut, pickles, buttermilk
Term
parts of a virus and where they are located
Definition
Nucleic Acid: DNA or RNA never both, Capsid: Protein coat made up of capsomeres, only found in some: Envelope: Developed when the virus lyses the cell. Spikes: Usually found with-in the envelope.
Term
Hallmark of Bdellovibrio?
Definition
Attacks other gram negative bacteria
Term
All facts about Staphylococcus aureus?
Definition
Phylum Firmuculates, Bacillales order, Gram-positive yellow pigmented colonies, facultative anaerobes, naturally occurring on our skin, in nostrils. Like high salt/OP & low moisture. Major problems in hospitals w/wounds. High levels of antibiotic resistance. Produces an enterotoxin that causes vomiting and nausea. TSS, food poisoning.
Term
What are spore producing anaerobe that overgrows after a strong course of antibiotics?
Definition
Clostridium difficile
Term
Which group has efflux pumps? why?
Definition
Pseudomondales; antibiotic resistance
Term
Which bacteria lack a cell wall?
Definition
Mycoplasma
Term
What makes a bacteria a spirochete?
Definition
Possess axial filaments (endoflagella)
Term
How are chlamydias and rickettsias different?
Definition
Rickettsia - transmitted by ticks, reproduce by binary fission, bacillus shaped, causes increased blood vessel permeability
Chlamydia - transmitted by contact, reproduce through reticulate bodies, coccus shaped, contagious portion is elementary body
Term
E. coli classification
Definition
Bacteria-No Kingdom-Proteobacteria-
Gammaproteobacteria-Enterobacteriales-
Enterobacteriaceae-Escherichia-E. Coli
GRAM NEGATIVE, bacillus shaped, facultative anaerobe
Term
Which bacteria are responsible for most infections and most different kind of infections?
Definition
Streptococcus (S. pyogenes, S. pneumoniae, S. mutans, S. agalactiae)
Term
Which animal transmit malariaa?
Definition
Anophelous mosquito
Term
What are the reason for difficulty establishing the etiology of cancer?
Definition
a. Cancer may not develop until long (25-35 yrs) after a viral infection that caused it
b. Cancer does not seem to be contagious & viral diseases usually are
c. Some viruses do not cause cancer at all.
Term
What is the most common accidental AIDS exposure with health care workers?
Definition
needle/syringe stick which is a fomite
Term
Ways to culture viruses?
Definition
in living animals, in embyonated eggs, in cell cultures
Term
What is special about Caulobacter?
Definition
Prosthecae (stalks)
Term
Which bacteria causes stomach cancer?
Definition
Helicobacter pylori
Term
Fungi facts?
Definition
Chemoheterotrophic, unicellular, low moisture, high salt, acidic environment EUKARYA
Term
Stages of Lytic cycle?
Definition
a. Attachment: Phage attaches to host cell.
b. Penetration: Phage penetrates host cell and injects the DNA.
c. Biosynthesis: Phage DNA directs synthesis of viral components by the host cell.
d. Maturation: Viral components are assembled into virions.
e. Release: Host cell lyses, and new virions are released
Term
Lytic cycle definition?
Definition
Cycle ends with death of host cell
Term
Acute
Definition
Short lived but with a sharp spike.
Term
Latent disease and example
Definition
dormant in the body; patient is asymptomatic
Chicken pox to shingles
Herpes to cold sores
Term
Persistent disease and example
Definition
Gradually progresses over a long period of time then suddenly causes death.
Measles to SSPE
Term
Example of fomites in the hospital
Definition
EVERYTHING except patient
Term
What is the major significance of Koch's Postulates?
Definition
Used to prove that microorganisms cause disease
Term
Problems with Koch's Postulates?
Definition
1) Some pathogens cause more than 1 disease (Streptococcus pyogenes)
2) Some pathogens only cause disease in humans
3) Not all diseases are cause my microorganisms
Term
What is the percentage of hospital patients that will get a nosocomial infection?
Definition
5-15%
Term
Most common nosocomial infection?
Definition
Staphylococcus aureus
Term
32% of nosocomial infections?
Definition
Urinary Tract infections
Term
22% of nosocomial infections?
Definition
Surgical site infections
Term
15% of nosocomial infections?
Definition
Lower respiratory infections
Term
14% of nosocomial infections?
Definition
Blood stream infections
Term
17% of nosocomial infections?
Definition
Other
Term
Patients will develop nosocomial infections if...?
Definition
Be present in the hospital setting
Have a compromised host
It is in the proper point in the chain of transmission
Term
5 stages of disease?
Definition
incubation period
prodromal period
period of illness
period of decline
period of convalescence
Term
Stage of disease when fever is the highest?
Definition
Period of illness
Term
Where does an endotoxin come from?
Definition
They are a part of gram negative cell walls. The Lipid A portion of the LPS layer.
Term
What are siderophores?
Definition
Protiens secreted from pathogens that bind up protein in the host cell.
Term
What is the parenteral route?
Definition
Portal of entry directly deposited into the tissues beneath the skin
Term
Most frequent portal of entry?
Definition
Respiratory tract mucus membranes
Term
Physical factors protecting skin?
Definition
Skin
Mucous membrane
mucous
ciliary escalator
lacrimal apparatus
saliva
urine
vaginal secretions
peristalsis, vomiting, defecating
Term
WBC that are the most phagocytic?
Definition
Neutrophil
Term
WBC associated with parasitic infections?
Definition
Eosinophil
Term
WBC associated with histamine?
Definition
Basophil
Term
Which complement proteins are involved in cytolysis?
Definition
C5b, C6, C7, C8, C9
Term
What are the effects of complement activation?
Definition
Opsonization, cytolysis, inflammation
Term
What viruses cause Hepatitis B?
Definition
Hep B Hepanaviridae
Term
Blood poisoning?
Definition
Sepsis
Term
Which complement proteins are involved in opsonization?
Definition
C3b
Term
Which complement proteins are involved in inflammation?
Definition
C3a & C5a
Term
What bacteria are diplococci shaped?
Definition
Neisseria gonorrhea
Term
What are the effects of histamine?
Definition
Inflammation blood vessel permeability, chemotactic attraction of phagocytes
Term
Hemoflagellates cause what genus of bacteria
Definition
Trypansoma
Term
What is Giardia lambia?
Definition
Protozoa, intestinal parasite that has a ventral sucker and releases oocysts - found in contaminated water
Term
What is Trichomonas vaginalis?
Definition
Protozoa with undulating membrane, no mitochondria and creates a frothy, nasty smell
Term
What is Plasmodium vivax?
Definition
Causative agent of malaria. Intermediate host is human, definitive host is mosquito
Term
What bacteria is associated with undercooked shellfish? What is the shape?
Definition
Vibrionales; curved (C)
Term
What bacteria is able to survive in disinfectant?
Definition
Burkholderia
Term
What bacteria is associated with restaurant grade poultry?
Definition
Camphylobacter Jejuni
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