Term
|
Definition
-atrial natriuretic peptides
-atrial > ventricular myocytes in response to inc volume or stretch |
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Term
|
Definition
-B-type natriuretic pepptide
-atrial < ventricular myocytes in response to inc V or streth |
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Term
| How to NT-proBNP and BNP relate? |
|
Definition
| -NT-proBNP is cleaved to BNP |
|
|
Term
| How do we measure BNP in cats? |
|
Definition
|
|
Term
| Compare/contrast Idexx and Antech. |
|
Definition
-Idexx: no special tubes, measures nt-BNP, dog & cats
-Antech: special tubes, measures BNP, dog ONLY |
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Term
| What is BNP mostly used to diagnose? |
|
Definition
-Dogs (Dobies): DCM
-Main coon & ragdolls: HCM |
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|
Term
| What are the general guidelines for using BNP? |
|
Definition
-test in appropriate population
-elevated: use more tests
-not specific to a particular dz
-evaluate in context |
|
|
Term
| What is BNP used as a prognostic tool for? |
|
Definition
| -Myxomatoud mitral valve dz in dogs |
|
|
Term
| What are the general recommendations for BNP as a prognostic indicator? |
|
Definition
-include rads & echo
-BNP unecessary if NO rads
-adjust recommendations baed on results |
|
|
Term
| What is Troponin? What does it do? |
|
Definition
-comglomeration of 3 proteins
-regs actin & myosin binding in all myocytes
-short half-tife |
|
|
Term
| What is the most common clinical troponin test? |
|
Definition
-Troponin I
-human assays will work in animals |
|
|
Term
| What does the troponin test tell you? |
|
Definition
| -myocardial injury from myocarditis, ischemia, cardiomyopathy |
|
|
Term
| When do we use troponin test? |
|
Definition
-unexplained arrhythmias (myocarditis)
-abnormal appearing myocardium on echo (myocarditis or neoplasia) |
|
|
Term
| How is Cocker Spaniel DCM different than the DCM in other breeds? |
|
Definition
| -related to taurine deficiency |
|
|
Term
| In which cats is genetic testing for HCM useful? Describe results. |
|
Definition
-RAgdolss & Naine Coons
-negative does not mean they won't get dz and vice versa |
|
|
Term
| In which dogs is genetic testing for DCM useful? |
|
Definition
-Boxers" ARVC
-Dobies: DCM |
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