Term
Char of CML
present at what age?
male or female |
|
Definition
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|
Term
phase of CML with <10% blasts
which is <15%
which is >20 |
|
Definition
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Term
etiology of CML-3
any of them heriditary? |
|
Definition
radiation
benzene
atomic bomb
no heriditary |
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Term
| Pathophys of CML is where what dominates hematopeosis |
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Definition
| single malignant trnasformation |
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Term
in CML there is aquisitoin of what mutation?
this generates what? |
|
Definition
philadelphia (9,22)
BCR-Abl tyrosine kinase |
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Term
| what makes up 95% of diagnosis for CML |
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Definition
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Term
what is the big symtpo of CML?
what cna it lead to-2 |
|
Definition
splenomegaly
abd pain, anorexia |
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Term
|
Definition
decreased Hgb
platelt cnt increased
WBC 25,000- 100,000
increased LDH/uric acid
increasefd Vit B12 |
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Term
| tx fo CML, the goal is it? |
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Definition
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Term
| the only cure for CML is? |
|
Definition
| bone marrow trnasplant (so the drugs just prolong survival) |
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Term
| drug therapies to help with CML-3 |
|
Definition
tyrosine kinase inhibitrs (1st line)
hydroxyurea
interferon+cyterabine |
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Term
def:
normalization of WBC, Plts, and no spenolmegaly |
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Definition
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Term
def:
has to do with Ph + findigns in FISH |
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Definition
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Term
def:
deals with mRNA findings of BCR Abl thru PCR analys |
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Definition
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Term
| * those with a complete+major resposne did better for survival |
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Definition
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Term
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Definition
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Term
dosing for gleevac for chronic CML
accelerated and blast? |
|
Definition
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Term
|
Definition
hepatox
meylosupp
edema
arthalgia |
|
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Term
| Heme respon btwn interferon + cytarabine vs gleevac |
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Definition
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|
Term
| complete cytoegnic rspn for gleevac vs interferon +cytarabine |
|
Definition
way more for gleevac!dastinib
nilotinib |
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|
Term
| 2 other drugs like imatinib that cna now be sued for CML |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| allogenic BMT can be used for CML if done with how long after diagnosis? |
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Definition
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|
Term
| is allogenic BMT affect by prior alpha interferon tx? |
|
Definition
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|
Term
| why is mortality rate from allogenic BMT high?-2 |
|
Definition
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|
Term
frist line treatment for CML TKI resitant
-chronic
-if accelerated/blast what else could be 1st line? |
|
Definition
TKI increase dose
allogenic trnasponatinib |
|
|
Term
| what med works agaisnt the T3151 mutation of CML? |
|
Definition
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|
Term
what meds marketing is suspending due to life threatneing blood clots?
what ar the FDA reccomednaitons-3 |
|
Definition
ponatiinib
dont start new pts, d/c if not working, eval in pts its working for |
|
|
Term
| whihc has more % of cancer, CLL or CML |
|
Definition
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|
Term
predispoing factors o CLL-2
what is viral/radiot risk level |
|
Definition
genetics (relativesa at incred risk)
unknwon etiology
no evidence |
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Term
|
Definition
lymphadenopahty of neck/shoulder
spenlomegaly
wt loss |
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|
Term
|
Definition
increased WBC
thombocytopenia
lymph >10,000 |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
| factros that mke CLL poor prognosis-5 |
|
Definition
short lymp doubling
CD38
ZAP 70
higher stage at dx
cytogenic abnormalites |
|
|
Term
| the most important cytogenic abnormaliy that causes shortest survivial for CLL is- |
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Definition
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|
Term
| what ppl dont you tx for CLL |
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Definition
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Term
| Tx for CLL, esp for elderly? |
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Definition
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Term
| tx for CLL that can have myleosuppression |
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Definition
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Term
| which tx for CLL do you need bactrim prophylaxis for? |
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Definition
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|
Term
| first linet tx for young and high risk CLL |
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Definition
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Term
| first line tx for elderly and high risk CLL |
|
Definition
| try fludarabine, if not then use single agent |
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|
Term
| firs tline tx fr elderly and low risk CLL |
|
Definition
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|
Term
| what drug do you pre tx with tyelnol, antihist, and steroid? |
|
Definition
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|
Term
| which trnasplant has mroe repsonse in CLL? |
|
Definition
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