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Exam 2 Reading Assignments
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38
Biology
Undergraduate 2
03/24/2010

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Term
Bactericide
Definition
chemical that destroys bacteria EXCEPT those in endospore stage
Term
Fungicide
Definition
chemical that kill fungal spores, hyphae, and yeasts
Term
Virucide
Definition
chemical known to inactive viruses, especially on living tissue
Term
Sporicide
Definition
agent capable of destroying BACTERIAL endospores
Term
Germicide/microbicide
Definition

chemical agent that kills PATHOGENIC microorganisms

 

used on inanimate and living tissue

Term
Disinfection
Definition

use of physical process OR chemical agent to destroy VEGETATIVE PATHOGENS but NOT bacterial endospores

 

also removes TOXINS

Term
Which process only works for inanimate objects?
Definition

disinfection

 

Ex: bleach, boiling, iodine solution

Term
Sepsis
Definition
growth of microorganisms in the BLOOD or other TISSUES
Term
Asepsis
Definition
practice that prevents entry of infectious agents into STERILE tissues --> prevents infection
Term
Antisepsis
Definition

CHEMICAL AGENTS applied directly to exposed body surfaces to destroy/inhibit VEGETATIVE PATHOGENS

 

Ex: iodophors, antibacterial soap, chlorhexidene

Term
Sanitation
Definition

cleansing technique that removes microorganisms from INANIMATE surfaces

 

Ex: dishwashing, laundering clothes

Term
Degermation
Definition

cleansing technique that removes microorganisms from LIVING TISSUE

 

Ex: alcohol wipes, surgical hand scrub

Term
Describe how surfactants work as microbial agents
Definition

They are nonselective and cidal

 

  1. They lower the SURFACE TENSION of cell membranes
  2. These polar molecules bind to the lipid layer and penetrate the internal hydrophobic region
  3. Leave "leaky spots"

Term
What are the 3 factors that must be considered before an actual antimicrobial therapy?
Definition

  1. Nature of infecting microorganism
  2. Degree of microorganisms sensitivity to drugs
  3. Overall medical condition of patient

Term
What could be examined as a way of rapid initial method for detecting the agent?
Definition
examine body fluids, sputum, or stool
Term
Penicillin is prescribed to fight:
Definition
streptococcus pyogenes
Term
What is the leading cause of meningitis in children?
Definition
streptococcus pneumoniae
Term
What is the second leading cause of meningitis in children?
Definition
neisseria meningitis
Term
3 Reasons why antimicrobial treatments fail:
Definition

  1. Drug cant diffuse into body compartment
  2. Unnoticed resistant cells
  3. Infection caused by more than one pathogen

Term
3 factors that influence choice on drug
Definition

  1. Nature & spectrum of drug
  2. Potential adverse effects
  3. Condition of patient 

Term
As a final drug selection, it is best to choose:
Definition
narrowest-spectrum drug since it decreases super infections and other adverse reactions
Term
Therapeutic Index (TI)
Definition
ratio of drug dose that is toxic to humans compared to its minimum effective (therapeutic) dose
Term
In take of other drugs: increases nephrotoxic effects
Definition
aminoglycides & cephalosporins
Term
In take other drugs: decrease absorption of isoniazid
Definition
antacids
Term
In take other drugs: these 2 antibiotics with oral contraceptives can take away its effectiveness
Definition
tetracycline & rifampin
Term
What are the 3 antiviral mode of actions?
Definition

  1. prevent penetration of virus into host
  2. block replication, transcription, translation of viral material
  3. prevent natural maturation of viral particles

Term
What drugs only treat Influenza A?
Definition
Amantadine and RImantidine
Term
what do the drugs treating influenza A block?
Definition
hemagglutinin receptors
Term
What drugs treat Influenza A and B?
Definition
Relenza and Tamiflu
Term
What do the drugs for Influenza A and B block?
Definition
neuraminidase enzymes
Term
What are compounds related to Acyclovir?
Definition

  1. valacyclovir (VALTREX)
  2. famiciclovir (FAMVIR)
  3. peniciclovir (DENAVIR)

Term
What was used to treat cytomegalovirus infections in immunocompromised?
Definition
ganciclovir (cytovene)
Term
What enzyme is used by viruses to process nucleosides?
Definition
thymidine kinase
Term
What is a retrovirus?
Definition

virus that carries genetic info in the form of RNA 

 

HIV and AIDS

Term
RNA genome is used as a template by which enzyme to produce a DNA copy of the genetic info?
Definition
reverse transcriptase
Term
What interferes with the synthesis of a new DNA strand
Definition
Nucleoside Reverse transcriptase inhibitors
Term
What virus infects the respiratory tract and produces giant multinucleated cells
Definition
RSV or Pneumovirus
Term
What are the treatments for pneumovirus (RSV)
Definition
synagis and ribavirin
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