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Exam 1
DNA, diffusion, action and membrane potential
69
Physiology
Undergraduate 1
09/20/2010

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Term
define homeostasis
Definition
maintenance of a state of dynamic constancy in which conditions are stabilized above and below a physiological set point by negative feedback loops
Term
What role does a sensor play in a negative feedback loop?
Definition
it detects that deviation from a set point (where we should be)
Term
What is an integrating center in a negative feedback loop?
Definition
it determines the response (the brain)
Term
What does the effector do in a neg. feedback loop?
Definition
it produces the response
Term
Is intrinsic or extrinsic control the type of control that is built into the organ being regulated?
Definition
intrinsic
Term
How common are positive feedback loops? What bodily systems are they involved in?
Definition
rare- blood clotting and ovulation
Term
Copying DNA to RNA is called____
Definition
transcription
Term
Copying RNA to a protein is called____
Definition
translation
Term
All genes in an individual or species are called_____
Definition
genomes
Term
All proteins produced by a genome are called_____
Definition
proteonomes
Term
What is chromatin made up of?
Definition
DNA and its associated proteins (histones)
Term
What are the 2 different types of chromatin?
Definition
euchromatin and heterochromatin
Term
What is heterochromatin and how is it different than euchromatin?
Definition
it is a highly condensed region of dna where genes are permanently inactivated
-euchromatin is active in transcription
Term
What are the 4 forms of RNA?
Definition
pre-RNA, mRNA, tRNA and rRNA
Term
Ribosomes read a triplet at a time. Each triplet is called a ____, which specifies an___ ____ ___.
Definition
codon, amino acid sequence
Term
What are proteins composed of?
Definition
amino acids
Term
What kind of transporters are involved in carrier mediated transport across the plasma membrane?
Definition
specific protein transporters
Term
How does non-carrier transport occur?
Definition
through diffusion
Term
Which was does passive transport move compounds? Does it require energy?
Definition
down the concentration gradient, no
Term
Which way does active transport move compounds? Does it require energy?
Definition
against the gradient, yes- energy and transporters
Term
____ compounds readily diffuse through cell membrane
Definition
nonpolar (fat soluble)
Term
What do polar compounds need to be able to permeate plasma membrane?
Definition
an ion channel or transporter
Term
Diffusion rates depend on what 4 variables?
Definition
1. magnitude of concentration gradient
2. permeability of membrane
3. temperature
4. surface area of membrane
Term
Define osmosis
Definition
net diffusion of H2O across a selectively permeable membrane
Term
H2O is (more/less) concentrated where there are more solutes.
Definition
less
Term
Solutes have to be ____ ____, i.e. cannot move across membrane.
Definition
osmotically active
Term
What are water channels called which facilitate osmosis?
Definition
aquaporins
Term
What is osmotic pressure? What does it indicate? How is it measured?
Definition
the force that would have to be exerted to stop osmosis; how strongly H2O wants to diffuse; molality
Term
Name 3 different types of tonicity and their osmotic pressures.
Definition
isotonic solutions- same osmotic pressures
hypertonic sol's- higher osmotic pressures
hypotonic sol's-lower osmotic pressures
Term
Relate isotonic, hypertonic and hypotonic solutions to blood plasma in osmolalities- what will happen to a red blood cell with each one?
Definition
isotonic-same as blood plasma
hypertonic- higher than blood plasma, cell will shrink
hypotonic- lower than blood plasma-cell will inflate
Term
Facilitated diffusion is considered ____transport and requires protein____.
Definition
passive, gates
Term
Na+ have higher concentrations ___the cell whereas K+ have higher concentrations____ the cell.
Definition
outside, inside
Term
Describe the Na+/K+ pump.
Definition
active transport to move Na+ and K+ against their gradients (Na+ out and K+ in)
Term
The transportation of digestion products across the intestinal epithelium into the blood- can happen anywhere.
Definition
absorption
Term
Transportation of compounds out of urinary filtrate and back into the blood- only happens in the kidneys.
Definition
reabsorption
Term
What is the name given to an uninsulated gap between schwann cells?
Definition
nodes of ranvier
Term
what are 4 types of EEG waves and their corresponding lobes?
Definition
alpha- parietal lobe
beta- frontal lobe
theta-temporal lobe
delta- cerebral cortex
Term
At what specific times do you see the 4 types of EEG waves?
Definition
alpha- person awake, relaxed and eyes closed
beta- evoked by visual stimuli and mental activity
theta- common in newborns; in adults indicates emotional stress
delta- adult sleep, awake infants; if adult awake, indicates brain damage
Term
Name 2 types of sleep and what each of their EEG waves look like.
Definition
REM- when dreaming occurs; waves are similar to awake ones
non-REM- consolidation of short term into long term memory; delta waves
Term
What abilities do each the right and left hemisphere possess?
Definition
right-visuospatial tasks
left-language and analytical abilities
Term
____ Area is necessary for speech and ____ Area is involved in language comprehension.
Definition
Broca's and Wernicke's
Term
What is the term which describes the voltage across a cell membrane if only 1 ion could diffuse?
Definition
equilibrium potential
Term
Which ion is more permeable Na+ or K+?
Definition
K+
Term
Na+ concentrations are ____outside the cell whereas K+ concentrations are _____inside the cell.
Definition
higher
Term
__ is attracted into cells by anions and __ is actively transported out.
Definition
K+, Na+
Term
What is membrane potential?
Definition
the difference in charge across membranes
Term
What is resting membrane potential?
Definition
the potential to have a charge; membrane voltage of cell is not producing impulses
Term
What is the common range of RMP for most cells?
Definition
-65 to -85 mV
Term
Which effects RMP more, Na+ or K+? Why?
Definition
K+ because it is more permeable
Term
What 2 factors is RMP dependent upon?
Definition
concentration gradients and permeabilities of K+ and Na+
Term
What results from:
-large cations trapped in a cell
-Na+ high count outside the cell
-K+ very permeable and high inside cell?
Definition
resting membrane potential
Term
How do depolarization, hyperpolarization and repolarization relate to the membrane potential?
Definition
depol.=(stimulation) occurs when MP becomes more positive
hyper.= (inhibition) MP becomes more negative than RMP
repol.= MP returns to RMP
Term
What is excitability in a cell? Examples?
Definition
cells can discharge their RMP quickly by rapid changes in permeability to ions (to generate and conduct impulses)
-neurons and muscle cells
Term
How are voltage gated channels affected by depolarization?
Definition
they are opened
Term
K+ and Na+ VG channels are ___ in resting cells.
Definition
closed
Term
During an action potential, what ion flows in the cell during depolarization? And out during repolarization?
Definition
Na+, K+
Term
Depolarization demonstrates a ____ feedback loop during an action potential.
Definition
positive
Term
Is stimulus activity coded by more or bigger action potentials?
Definition
more, never bigger
Term
When the membrane cannot produce another AP because its sodium channels are inactivated this is called _______.
Definition
an absolute refractory period
Term
A relative refractory period happens when VG___ channels are open, making it harder to depolarize to threshold.
Definition
K+
Term
Are myelinated or unmyelinated axons faster? Why?
Definition
myelinated because no AP's occur under myelin and no current leaks; AP's only occur at nodes of Ranvier
Term
The release of___ at a chemical synapse is triggered by the AP.
Definition
neurotransmitters
Term
What are EPSP's and what are they caused by?
Definition
excitatory postsynaptic potentials
-depolarizing channels
Term
What are IPSP's and what are they cause by?
Definition
inhibitory postsynaptic potentials
-hyperpolarizing channels
Term
Where do EPSP's and IPSP's occur?
Definition
cell bodies and dendrites
Term
What is acetylcholine? What are the names of its two different receptors? Is it excitatory or inhibitory?
Definition
a neurotransmitter
-nicotonic and muscarinic
-it can be either
Term
Where and what inactivates acetylcholine?
Definition
acetylcholinesterase in the synaptic cleft
Term
Name 3 neurotransmitters in the CNS. Which one can also be active in the PNS?
Definition
Norepinephrine, dopamine, and serotonin.
-norepinehprine
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