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Exam 1
Exam 1 Kumi Diaka Summer 2012
58
Immunology
Graduate
05/28/2012

Additional Immunology Flashcards

 


 

Cards

Term
immunology
Definition
electro-chemical network of the body system body's defense system
Term
pathogens
Definition
Enemies to the body that cause diseases. They are needed to activate the immune system.
Term
Immune system is ______ dependent
Definition
antigen
Term
What are the 2 forms of immunity?
Definition
innate and acquired
Term
immune system
Definition
ability to recognize what does not belong; network of cells and lymphoid organs that owrk togeether to defen against foreign invadors aka pathogens
Term
Name the different kinds of pathogens
Definition
bacteria, viruses, parasties, fungi
Term
If the immune system misfires the result is ______
Definition
autoimmune disease such as allergy, arthritis, cancer, AIDS
Term
T/F All antigens are pathogens
Definition
False
Term
If you do not a have a ____ marker you are an invador
Definition
self
Term
Every single antigen has a
Definition
marker
Term
antigen
Definition
anything that triggers the immune response
Term
Name examples of antigens
Definition
allergens, viruses, parts of viruses, bacteria, protozoa, tissue or cells (except from identical twins), nutrients
Term
allergen
Definition
unharmful antigen that triggers immune response such as cat hair, pollen
Term
Body will reject nourishing proteins in food unless they are broken down by
Definition
digestive system
Term
T/F Not all foods are nutrients
Definition
True
Term
Autoimmune disease
Definition
when the body mistakes itself for nonself (arthritis)
Term
Lymphoid organs
Definition
produce lymphocites that protect you. Dependent upon level of development
Term
Name 2 major lymphoid organs and functions
Definition

bone marrow-cytogenesis; source of rbs and wbs

Thymus- organ behind breast bone; where lymphocytes become T cells

Term
Under normal conditions, whole body is covered immunologically with
Definition
lymphoid organs
Term
What are blood's 4 components and what are their componenets
Definition

Plasma- proteins, glucose, cell waste, extracellular fluid

WBC-granulocytes and agranulocytes

Platelets-clotting

RBCs- contain hemoglobin which carry O2

Term
Cluster Designations (CD)
Definition
international nomenclature of cell surace proteins that antibodies recognize.
Term
Cell surface proteins may look the _____ but perfom _____ functions
Definition
same, different
Term
What occurs with immune response with first exposure to toxin/antigen?
Definition
no immediate antibodies detectable time lag --> Abs detectable in serum after several days--> level peaks --> declines--> disappears. --> confers relatively small immunity.
Term
What occurs with immune response with 2nd exposure to toxin/antigen?
Definition
shorter time lag --> rapid ---> rise serum Abs--> greater peak --> declines slowly --> Abs detected for months after injection.
Term
What occurs with immune response with 3rd exposure to toxin/antigen?
Definition
even shorter lag time --> faster and higher peak --> more pronounced Ab response
Term
Vaccination
Definition
stimulation of resistance to disease through the use of repeated injections of antigens --> basis of current vaccination techniques.
Term
Cell mediated;skin from a dog --> grafted --> unrelated dog -> survives --> rejected slowly. This slow rejection is called
Definition
first set reaction
Term
Cell mediated: If 2nd skin draft from same donor -> same recipient -->rapid rejection within days. This rapid rejection process of the 2nd graft is called
Definition
second set reaction
Term
Name all the myeloid cells
Definition
neutrophil, eosinophil, basophil, monocytes
Term
monocyte
Definition
myeloid stem cell; circulate in bloodstreams, migrate to tissue and differentiate into macrophages
Term
macrophage
Definition
phagocytic; secrete hydrolytic enzymes, soluble factors, and cytotoxic proteins
Term
dendritic cell
Definition
myeloid; potent antigen presenting cell (APC), no activation needed
Term
neutrophil
Definition
myeloid, phagocytic; first response to inflammation
Term
eosinophil
Definition
myeloid; phagocytic; anti-parasitic
Term
basophil
Definition
myeloid; nonphagocytic; allergic responses
Term
3 sentinel cells of innate that contain TLR
Definition
macrophages, mast cells, dendritic cells
Term
What are the granulocytes?
Definition
BEND
basophils, eosinophils, neutrophils, dendritic cells
Term
What are the agranulocytes?
Definition
lymphocytes, NK cells, monocytes, mast cells
Term
List all phagocytic cells
Definition
monocytes, eosinphils, neutrophils
Term
histiocytes
Definition
macrophages in connective tissue
Term
kupffer cells
Definition
macrophages in liver
Term
microglia
Definition
macrophages in brain
Term
alveolar
Definition
macrophages in lungs
Term
promonocytes
Definition
macrophages in bone marrow
Term
The phagocytic cells of mammals belong to 2 complementary systems:
Definition
The myeloid system ( rapid action but incapable of sustained effort) predominant cell: macrophages are able to replicate themselves


The mononuclear-phagocytic system (cells that act more slowly but capable of sustained and repeated phagocytosis)
Term
immunogenicity
Definition
the ability to induce immune response (humoral and/or cell mediating immune response)
Term
Antigenicity
Definition
ability to combine specifically with antibodies and/or cell surface receptors
Term
Immunogen
Definition
is an antigen but an antigen is not an immunogen
Term
Hapten
Definition
small molecules that posses the properties of antigenicity but are not capable of inducing immune response because they lack immunogenicity
Term
immunogenicity
Definition
the ability to induce immune response (humoral and/or cell mediating immune response)
Term
Antigenicity
Definition
ability to combine specifically with antibodies and/or cell surface receptors
Term
Immunogen
Definition
is an antigen but an antigen is not an immunogen
Term
Hapten
Definition
small molecules that posses the properties of antigenicity but are not capable of inducing immune response because they lack immunogenicity
Term
Epitopes or antigenic determinants
Definition
macromolecule/antigesn have areas on their surfaces gainst which immune response tends to be directed an where antibodies bind.
Term
The selection of epitopes by immune system is controlled by genes called
Definition
immune response genes
Term
globulin
Definition
antibody serum protein precipitate when protein in serum is added with saturated (NH4)2S04 solution
Term
albumin
Definition
antibody that remains in solution when protein in serum is added with saturated (NH4)2S04 solution
Term
The primary structure, the amino acid sequence, accounts for the variable and constant regions of the heavy and light chains. (T/F?)
Definition
True
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