• trade: 
• half-life: 
• MoA: mu receptors in brain. ("mu" refers to morphine after all)
• Elim: 
• Rx: analgesic to relieve pain. STRONG
• tox: 

  -Constipation (mu-rec myenteric plexus)

  - Addiction (psychological and physiological)

  -Tolerance 

• Contras: 

-triprolidine, CNS depressant, may increase toxic effects due to additivity 

-Trovafloxacin, an antibio, levels may be reduced when used with morphine

-Rifampin, an AB, decreases effect of morphine.

- avoid alcohol, take w food

• trade: 
• half-life: 
• MoA: mu receptors in brain, NMDA, delta
• Elim: 
• Rx: analgesic to relieve pain, depressant action on cough center, treatment for opiod dependance. STRONG
• tox:  
• Contras: 

• trade: 
• half-life:
• MoA: similar to morphine. mu and delta agonist. 
• Elim:
• Rx: treat moderate or severe pain. treat hacking cough due to bronchitis. MODERATELTY STRONG. 
• tox:

mech of mu receptor

1. morphine (or other) binds to mu rec on post syn mem of neuron

2. inhibits GABA release from neuron

3. GABA normally inhibits DA release from another neuron. Therefore, DA release increases.

• trade: 
• half-life:
• MoA: converted to morphine in liver. acts on mu-receptors
• Elim:
• Rx: analgesic to relieve mild/moderate pain. cough, IBS, diarrhea, narcolepsy. MODERATELY STRONG.
• tox: euphoria, itching, urinary retention, depression, constipation, ED

• trade: 
• half-life:
• MoA: mu-rec, kappa-rec, K+ channels, muscarinic rec, 
• Elim:
• Rx: analgesic to relieve mod/severe pain. also for antispasmotic effects. STRONG
• tox: serotonin syndrome--xs serotonin in CNS and periph

• ??? -- lecture notes suck
• trade: 
• half-life:
• MoA: agonist-antagonist!! mu-antagonist, k-agonist, d-agonist
• Elim:
• Rx: 
• tox: