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escherichia coli
ONU med micro r-anderson
22
Microbiology
10/20/2011

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Term
etiology
Definition
GM-
peritrichous flagella
lactose fermentation
faculatatively anaerobic
normal flora and pathogenic mutants
Term
types of pathogenic
Definition
entertoxigenic (etec)
enterhemorrhagic (ehec)
enterinvasive (eiec)
Term
etec signs
Definition
watery diarrhea produced by choler-like entertoxin
Term
ehec signs
Definition
bloody diarrhea produced by verotoxin (cytotoxin)
HUS complications
Term
eiec signs
Definition
bloody diarrhea
enters cells and causes tissue disruption and inflammation
Term
E. coli O157:H7 differences
Definition
antigenic - O157 on LPS and H7 on flagella
growth - does not ferment sorbitol
Term
MacConkey Agar partz
Definition
agar, peptone, lactose, bile salts, neutral red
Term
red dots on MacConkey agar mean...
Definition
E. coli!!!
Term
reservoir
Definition
guts of cattle
Term
mode of transmission
Definition
common vehicle - fecal contaminated undercooked beef (hamburger)
Term
diagnosis
Definition
modified MacConkey agar (SMAC)
Term
SMAC differences
Definition
sorbitol rather than lactose
cefixime and K tellurite - suppress other sorbitol fermenters
Term
white dots on SMAC agar mean...
Definition
E. coli O157:H7
Term
clinical features
Definition
3-5 day incubation period
stomach cramps, bloody diarrhea, vomiting, maybe fever
Term
Hemolytic uremic syndrome
Definition
(HUS) develops in 5-10% of patients
develops as disease subsides
less urination, tired, loosing pick color
Term
entry
Definition
oral fecal route from contaminated beef
Term
attachment
Definition
adhesins on fimbriae attach to large intestine epithelium
Term
avoid host defenses
Definition
protected environment
Term
damage
Definition
shiga-like cytotoxin kills cells
vascular damage allow inflammation mediators into bloodstream which can lead to HUS
endotoxin - interlukin and TNF
Term
exit
Definition
feces
Term
treatment
Definition
fluids
no antibiotics or antidiarrheals
hospitalization with HUS
Term
prevention
Definition
through cooking of beef