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Endocrinology Male Reproductiv
Endocrinology Male Reproductiv
30
Science
Undergraduate 4
04/20/2009

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Term
Male Hypogonadism: Kallmann's syndrome
Definition
Hypogonadism caused by a deficiency of gonadotropin-releasing hormone, created by hypothalamus.
Term
Kallmann Syndrome
Definition
secondary hypogonadism reflecting that the primary cause of defect in sex hormone production lies within the pituitary and hypothalamus rather than a physical defect of the teses or ovaries themselves. hypogonadism, congenital, ansomia, or hyposmia.
Term
Pathophysiology
Definition
Hypophyseal portal system, triggers production and release of LH and FSH from gonadotropes. When low, pituitary does not create normal amount of gonadotropins. normally increase production of gonadal steroids. will be low
Term
Kallmann syndrome
Definition
GnRH neurons do not migrate properly from olfactory placode to hypothalamus during development. Olfactory bulbs fail to form or have hypoplasia, leading to anosmia or hyposmia.
Term
Symptoms and Signs of Kallmann's syndrome(puberty)
Definition
Decresed development of muscle mass, lack of deepening of voice, impaired body hair, impaired growth of penis and testicles, excessive grotwh of the arms and legs in relation to the trunk of body, gynecomastia.
Term
Signs and Symptoms of Kallmann's Syndrome (adulthood)
Definition
Hypgonadism in adult males may alter certain muscles impairing normal reproductive function. Erectile dysfunction, Infertility, Decrease beard and body hair, increase body fat, decrease size or firmness of testicles, decrease in muscle mass, development of breast tissue, loss of bone mass.
Term
What is the main health risk for untreated Kallmann syndrome?
Definition
Osteoporosis
Term
What is the treatment for Kallmann's syndrome?
Definition
Hormone Replacement Therapy. Males receive hCG or testosterone. Females with estrogen and progestins.
Term
Male Pseudohermaphroditism
Definition
form in which affected individual is genetic and gonadal male with incomplete masculinization. 45 XY. gonads testeds, but genital ducts are external genitalia are female. secondary sex characteristic s may never appear while some may have fully feminized physique
Term
Semen analysis
Definition
measures amount of semen and quality of sperm. determines infertility. Volume measure how much semen. Liquefaction time-thick gel becomes liquid whitin 20 minutes. Sperm count. Sperm morphology. Sperm motility. pH. white blood cell. Fructos level
Term
Testicular Biopsy
Definition
Helps determine cause of male infertility. abnormal count or hormone results withing normal range it is done. not used to detect testicular cancer.
Term
Precocious Puberty
Definition
Early development of sexual characteristics. Most children grow fast at first, but finish early. most don't grow above 5'2"
Term
Cause of precocious puberty
Definition
Tumors or growths of ovaries, adrenal glands, pituitary gland, or brain. May include CNS abnormalities, family history, genetic syndromes.
Term
GnRH dependant precocious puberty
Definition
Central precocious puberty. most common, premature secretion of FSH and LH
Term
Gonadotropin-independent precocious puberty
Definition
not triggered by early release of FSH,LH. Group of disorders sex steroid-producing tumors. Androgens from testis or adrenal are increased but gonadotropins low.
Term
Diagnositic Testss for Precocious Puberty
Definition
X-ray, Measurement of Gonadotropins, Ultrasound, Gonadotropin-stimulating hormone test, Magnetic Resonance Imaging
Term
Testis
Definition
paired male gonad located outside the body cavity in the scrotum. egg-shaped?
Term
Tunica Vaginalis
Definition
Serous sac that is invested with the testis
Term
Tunica Albuginea
Definition
Smooth white capsule from which septa extend into the organ to divide it into approximately 250 pyramidal lobules. Each lobule containiing 3 tightly packed and highly convuluted seminiferous tubules.
Term
What is the tubulus rectus?
Definition
short straight tube formed from each lobule.
Term
What are the rete testis?
Definition
network of interconnnecting tubes which empty into the efferent ducutles
Term
What empties into the efferent ductules?
Definition
The rete testis
Term
What is the epididymis?
Definition
Postero-lateral aspect of testis which is a tightly coiled tube from posterior aspect of testis.
Term
Where do the efferent dutules drain?
Definition
Into the duct of the epididymis head or caput.
Term
Where does the epididymis become the ductus or vas deferens?
Definition
At the inferior pole of the testis.
Term
What structure does the vas deferens become as it ascends behind the testis?
Definition
Spermatic cord, whic also contains the artery, vein and lymphatics.
Term
Seminiferous tubule
Definition
surrounded by a well-defined basement membrane. epithelium composed of two cells: sustenacular called sertoli cells, and spermatogenic or germ cells.
Term
Sertoli Cells
Definition
non-proliferating elongated cells whose cytoplasm extends from the basement membrane to the lumen of the tubule.
Term
Spermatogenic cells
Definition
Actively replicating cells at various stages of a complex differentiating process called spermatogenesis.
Term
What is the relative quantity of spermatogonia before the onset of puberty?
Definition
Small
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