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Endocrine
Unit 6
40
Pathology
Undergraduate 3
12/06/2009

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Term

Water-soluble hormone

 

Definition
Receptors are located in the plasma membranes of cells
Term
Lipid-soluble hormones
Definition
Enter the cell easily
Term
Diurnal patterns
Definition
Happening daily
Term
Pulsatile + Cyclic patterns
Definition
Rhythmic pulsations and time cycles
Term

Endogenous

 

Definition
Produced from with in
Term
Exogenous
Definition
Originating outside the body
Term
Ectopic
Definition
Out of place; hormone secreted from an unexpected organ
Term
Oxytocin
Definition
Milk letdown in response to suckling
Term
ADH
Definition
Antidiuretic Hormone increases permeability to water in the kidneys
Term
SIADH
Definition

High levels of ADH

Causes: stress, temp extremes, CNS tumors

Fatigue, vomiting, abdominal cramps

Term
Diabetes Insipidus
Definition

Low levels of ADH

Polyurea, polydipsia, decreased body weight

Term
Posterior Pituitary Hormones
Definition

Oxytocin

ADH

Term
Anterior Pituritary Hormones
Definition

FLATPEG

FSH, LH, ACTH, TSH, Prolactin, Epinephrine, Growth Hormone

Term
ACTH
Definition
Controls manufacture and secretion of hormones(glucocorticois&adrenal androgens)
Term

GH

 

 

Definition

Growth Hormone(somatotropin)

stimulates body cells to increase in size

*cronically inhibited*

Term
TSH
Definition

Thyroid stimulating hormone

Thyrotropin controls the secretions of hormones from thryorid glad T4 and T3

Term
Prolactin
Definition
Necessary for milk production and lactation
Term

FSH

Gonadotropin

 

 

 

Definition

Responsible for growth and development of egg-containing follicles (females)

Stimulates sperm production(males)

Term

LH

Gonadrotropin

Definition

Promotes teh secretion of sex hormones in both males and females

essential for the release of egg cells from the female ovaries

Term

hypopituiarism

 

 

 

Definition
absence of selective anterior pituitary hormones
Term
Hyperpituitarism
Definition
excess secretion of anterior pituitary hormones
Term
Thyroid Hormones
Definition

T3&T4

Increase cell metabolism, necessary for normal growth of cns

Term
Graves' Disease
Definition

Hyperthyroidism Normally Primary, Low TSH levels

Hyperactivity, tremors, irritability, fatique, protruding eyes

Term
Myxedema/Cretinism
Definition

Hypothyroidism

Primary= high tsh

Secondary =low tsh

slowed speech, memory deficit, lethargy, wt gain, decreased metabolism

Term
Parathyroid Hormone
Definition

regulates calcium levels in blood via acting on bone(resorption) and kidneys(reabsorption) and absorption in the gut via vit d.

Low ca lead to high pth

high ca leads to low pth

Term
hypoparathyroidism
Definition
low levels of pth, causes muscle excittation=tetany
Term
chvosteks sign
Definition
tap over massester, if positive will have twitching of facial muslces in hypoparathyroidsim
Term
Trousseau's sign
Definition
when taking BP, hand will become tight, will have carpopedal spasms when hypoparathyroidism
Term
Hyperparathyoisism
Definition

high pth levels

primary: adenomas

Secondary: hyperplasia from chronic hypocalcemia

tertiary: chronic renal failure

Bone demineralization, fractures, renal failure and stones

Term
Calcitonin
Definition
Inhibits bone resorption, lowers calcium levels in the blood
Term
Adrenal Cortex Hormones
Definition

Glucocorticoids=cortisol

mineralcorticoids=aldosterone

adrenal androgens=DHEA

Term
Aldosterone
Definition

Water and Na reabsorption

Renin-angiotension

Term

Cortisol

(glucocorticoid)

Definition

Metabolic anti-inflammatory

Immune response

Term
Adrenal Androgens
Definition

steroid cyclical relase

promotes secondary sex characteristics

Term
Cushing's Disease
Definition

Increased ACTH

Wt gain in face and trunk, moon hyperpigmentation of skin

Term
Conn's Disease
Definition

Hyperaldosteronism

tumor of adrenal cortex or increased renin and angiotensin

hypertension, hypernaturemia, hypokalemia.

Term
Addison's Disease
Definition

Hyposecretion of ACTH

hypotension, hypoglycemia, inability to tolerate stressors, depression

Term
Type 1 Diabetes
Definition
No insulin made, autoimmune destruction of beta cells, early onset, DKA, antibodies to islet cells
Term
Type 2 diabetes
Definition
90% of cases, late age onset in obsese, insulin resistance, HHNK
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