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EAS Substituent Effects
Electrophilic aromatic substitution
6
Organic Chemistry
Undergraduate 2
10/16/2013
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Term
strongly activating
 Definition
-OH, -OR (ortho para)
Term
moderately activating
 Definition
-NH2, -NH-R, -NRR' (ortho para)
Term
weakly activating
 Definition
-R, -Ar (ortho para)
Term
weakly deactivating
 Definition
-Br, -Cl, -I, -F (ortho para)
Term
moderately deactivating
 Definition
-COR, -COH, -COOR, -COOH (meta)
Term
strongly deactivating
 Definition
-NO2, -CN, -N+R3, -SO3H
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