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Drugs of Abuse / Nicotine / Alcohol
n/a
20
Pharmacology
01/09/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Donabinol
Definition

THC Analogue

(Nabilone)

 

Acts on cannabinoid receptors

Term
LSD (Lysergic Acid Diethylamide)
Definition

Hallucinogen

 

- 5-HT2 partial agonist

- High degree of tolerance

Term
Mescaline
Definition

Hallucinogen

 

Serotonin and dopamine agonist

From Peyote Cactus

Term
Phenyclidine
Definition

Hallucinogen

 

3 Mechanisms:

- NMDA antagonist

- Sigma (opiod) agonist

- Dopamine and NE reputake inhibition

Term
Dextromethorphan
Definition

OTC Abuse

(cough suppressant)

 

NMDA antagonist

Term
Dimenhydrinate
Definition

OTC Abuse

(motion sickness)

 

Anticholinergic

Term
Inhalants
Definition

Activate dopamine

 

Side Effect - neurotoxicity, demyelination

Term
Buproprion (Wellbutrin)
Definition

Smoking Cessation

- often combined with other therapies

 

Antidepressant

- Decreases NE and Dopamine reuptake

- Weakly blocks dopamine, serotonin, and NE transporters

Term
Varenicline (Chantix)
Definition

Smoking Cessation

 

- High affinity A4B2 nicotinic receptor partial agonist

- Moderate affinity 5HT-3 receptor agonist

Term
Mecamylamine
Definition

Smoking Cessation

 

- Non-selective antagonist of non-A7 nicotinic receptors

- Crosses BBB

- Antihypertensive

Term
Ethanol
Definition

MOA - ion-channel alteration

 

Ethanol --> alcohol dehydrogenase --> Acetaldehyde --> acetaldehyde dehydrogenase --> CO2 and H2O

 

Microsomal Ethanol Oxidizing System may be also have a role in alcohol metabolism with chronic use

Term
Methanol
Definition

(Wood Alcohol)

 

Metabolized to formaldehyde and formic acid

- Treat OD with ethanol, fomezapole, and dialysis

- Side effects - blindness, acidosis

Term
Fomezipole
Definition

Treat Methanol and Ethylene Glycol Intoxication

 

MOA - inhibits alcohol dehydroxylase

Term
Thiamine
Definition

(Vitamin B1)

 

Treatment of CNS Alcohol Toxicity and Werkicke-Korsakof Syndrome

Term
Naltrexone
Definition

Treatment of Chronic Alcoholism

 

- Opiod receptor antagonist

- Decreases relapse

Term
Ondansetron
Definition

Treatment of Chronic Alcoholism

 

-5-HT3 antagonist

Term
Topiramate
Definition

Treatment of Chronic Alcoholism

 

- AMPA (glutamate) antagonist and GABA modulator

Term
Disulfiram
Definition

Treatment of Chronic Alcoholism

 

- Acetaldehyde dehydrogenase antagonist

- Increases acetaldehyde --> hangover symptoms

- SE - Acetaldehyde Syndrome: Increased HR, hypotension, N/V, headache

Term
Diazepam
Definition

Treatment of Alcohol Withdrawal

 

- Increases effects of GABA (benzodiazepine)

- Longer acting than Lorazepam

Term
Lorazepam
Definition

Treatment of Alcohol Withdrawal

 

- Increases effects of GABA (benzodiazepine)

- Shorter acting than Diazepam