Shared Flashcard Set

Details

Drugs MOA
CRaP, Step, & Beyond
89
Medical
Graduate
12/03/2012

Additional Medical Flashcards

 


 

Cards

Term
Digoxin
Definition
Na+/K+ pump inhibitor
Term
Dobutamine
Definition
Selective beta-1-agonist
Term
Quinidine
Definition
Na+ Channel Blocker (Class Ia)
Term
Propranolol
Definition
Non selective beta 1/2- blocker (class II)
Term
Metoprolol
Definition
Selective beta-1 blocker (Class II)
Term
Carvedilol
Definition
Non selective beta 1/2- blocker + alpha-1 blocker (class II)
Term
Labetalol
Definition
Non selective beta 1/2- blocker + alpha-1 blocker (class II)
Term
Sotalol
Definition
K+ Channel blocker (Class III)
Term
Ibutilide
Definition
K+ Channel blocker (Class III)
Term
Amiodarone
Definition
K+ Channel blocker (Class III)
Term
Milrinone
Definition
Phosphodiesterase Inhibitor
Term
Levosmiendan
Definition
Sensitizer, inhibits phosphodiesterase (at high dose)
Term
Unfractionated Heparin
Definition
Binds and activates antithrombin III
Term
Low Molecular Weight Heparin (Enoxaparin)
Definition
Binds and activates antithrombin III
Term
Warfarin
Definition
Inhibits Vit K reductase
Term
Dabigatran
Definition
Direct thrombin inhibitor
Term
Streptokinase
Definition
Binds plasminogen, promotes conversion to plasmin
Term
Tissue Plasminogen activator
Definition
Binds plasminogen, promotes conversion to plasmin
Term
Tenectaplase
Definition
Binds plasminogen, promotes conversion to plasmin
Term
Aspirin
Definition
Irreversible Cox-1 inhibitor
Term
Clopidogrel
Definition
Irreversible ADP receptor inhibitor
Term
Abciximab
Definition
Glycoprotein IIa/IIIa inhibitor
Term
Erythropoietin
Definition
Stimulates bone marrow to make RBCs
Term
Aliskiren
Definition
Renin inhibitor
Term
Lisinopril
Definition
Angiotensin-converting enzyme inhibitor
Term
Losartan
Definition
Angiotensin II receptor (AT1) antagonist (ARB)
Term
Bosentan
Definition
Non selective endothelin-1 receptor antagonist
Term
Ambrisentan
Definition
Selective endothelin-1 receptor antagonist
Term
Nesritide
Definition
Brain natriuretic peptide analog
Term
Dopamine
Definition
D1 agonist (low), beta1 agonist (mid), alpha1 agonist (high)
Term
Clonidine
Definition
Pre-synaptic alpha-2 receptor agonist
Term
Alpha-methyldopa
Definition
Pre-synaptic alpha-2 receptor agonist
Term
Phentolamine
Definition
Nonselective competitive alpha 1/2 blocker
Term
Prazosin
Definition
Selective competitive alpha 1/2 bladder
Term
Nifedipine
Definition
Ca2+ channel blocker (CLass IV), mainly coronaries
Term
Dilatiazem
Definition
Ca2+ channel blocker (Class IV), coronaries + nodes
Term
Verapamil
Definition
Ca2+ channel blocker (Class IV), coronaries + nodes + contractility
Term
Hydralazine
Definition
Unknown (nitric oxide?)
Term
Minoxidil
Definition
Activates vascular ATP-sensitive K+ channels
Term
Diazoxide
Definition
Activates vascular ATP-sensitive K+ channels
Term
Ranolazine
Definition
Na+ channel blocker (transcellular late Na+ channel)
Term
Nitroglycerin
Definition
Nitric oxide donor (guanylyl cyclase activator)
Term
Nitroprusside
Definition
Nitric oxide donor (guanylyl cyclase activator)
Term
Atorvastatin
Definition
HMG-CoA Reductase inhibitor
Term
Cholestyramine
Definition
Bile salt sequestrant
Term
Ezetimibe
Definition
Cholesterol absorption inhibitor
Term
Fenofibrate
Definition
Nuclear PPAR-alpha agonist
Term
Fish Oil
Definition
Omega-3 fatty acid
Term
Niacin
Definition
MOA: Unknown

Net Effect: Blocked synthesis of VLDL from the liver, lipolysis
Term
Hydrochlorathiazide (HCTZ)
Definition
NaCl transport inhibitor (early DCT)
Term
Chlorthalidone
Definition
NaCl transport inhibitor (early DCT) - longer half-life
Term
Furosemide
Definition
Loop Na-K-2Cl- co-transporter inhibitor
Term
Amiloride
Definition
Na+ channel blocker (collecting duct)
Term
Spirnolactone
Definition
Aldosterone antagonist (collecting duct)
Term
Acetazolamide
Definition
Carbonic anhydrase inhibitor
Term
Amlodipine
Definition
Ca2+ channel blocker
Term
Calcitrol
Definition
Hormonally active form of Vit D
Term
Paricalcitol
Definition
Analog of Vit D (Vit D agonist)
Term
Sevelamer
Definition
Binds dietary phophate and prevents absorption
Term
Lanthanum carbonate
Definition
Binds dietary phophate and prevents absorption
Term
Vaptans
Definition
Vasopressin receptor blocker
Term
Ampicillin
Definition
Competitive inhibitor of transpeptidase (PCN)
Term
Gentamicin
Definition
Binds bacterial ribosome subunt 30S (aminoglycoside)
Term
Thymoglobulin
Definition
Antibody against human T-cells
Term
Mycophenolate mofetil (MMF)
Definition
Inosine mono-phosphate dehydro-genase inhibitor
Term
Cyclosporine
Definition
Calcineurin inhibitor, blocking IL2
Term
Tacrolimus
Definition
Reduces IL2 production by T-cells
Term
Prednisone
Definition
Steroid - downreg of cells/cytokines; lipocortin-1 up
Term
Fluticasone
Definition
Steroid - downreg of cells/cytokines; lipocortin-1 up
Term
Triamcinolone
Definition
Steroid - downreg of cells/cytokines; lipocortin-1 up
Term
Cromolyn sodium
Definition
Mast cell Cl- channel inhibitor
Term
Zileuton
Definition
Lipoxygenase inhibitor
Term
Montelukast
Definition
Leukotriene receptor blocker
Term
Omalizumab
Definition
Anti-IgE humanized monoclonal antibody
Term
Histamine
Definition
binds histamine receptors
Term
Albuterol
Definition
Short-acting beta2-agonist
Term
Formoterol
Definition
Long-acting beta2-agonist
Term
Salmeterol
Definition
Long-acting beta2-agonist
Term
Terbutaline
Definition
Beta2-agonist
Term
Ipratropium bromide
Definition
Muscarinic ACh receptor blocker
Term
Tiotropium
Definition
Muscarinic ACh receptor blocker
Term
Theophylline
Definition
Phosphodiesterase inhibitor, adenosine inhibitor
Term
Gefitinib
Definition
EGFR tyrosine kinase inhibitor (ATP-binding site)
Term
Erlotinib
Definition
EGFR tyrosine kinase inhibitor (ATP-binding site)
Term
Crizotinib
Definition
EGFR tyrosine kinase inhibitor (ATP-binding site)
Term
Itraconazole
Definition
Inhibition of fungal ergosterol synthesis
Term
Ivacaftor
Definition
Improvement of Cl- transport through CFTR channel
Term
Diphenhydramine, Chlorpheniramine, Promethazine, Dimenhydrinate, Hydroxyzine
Definition
Histamine1-receptor antagonist (1st gen)
Term
Cetirizine, Desloratine, Fexofenidine, Loratidine
Definition
Histamine1-receptor antagonist (2nd gen)
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