Term
|
Definition
| coricosteroids, calcineurin inhibitors, mTOR, cytoxoxic agents |
|
|
Term
| used to prevent rejection of grafted tissue |
|
Definition
|
|
Term
| side effects of corticosteroids |
|
Definition
| adrenal insufficiency, osteoproosis, increased risk of infection, muscle wastin, thin skin, fluid and electorlyt imbalances, glucose intolerance, psychologic disturbances, peptic ulcer disease |
|
|
Term
| corticosteroids nursing interventions |
|
Definition
| doses must be tapered off when discontinued to prevent acute adrenal insufficienct, protect patient form sources of infection, protect fragile skin from trauma |
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|
Term
|
Definition
|
|
Term
| used to rpeved rejection of transplanted tissue by reducint proliferation of B cells and cytotoxic T cells |
|
Definition
|
|
Term
| side effects of calcineruin inhibitors (CI) |
|
Definition
| nephrotoxicity, infection, hepatotoxicity, lymphoma, hypertension, anaphylaxis with IV route |
|
|
Term
| _ inhibits metabolism, raising CI blood level |
|
Definition
|
|
Term
| oral solutions of CI can be mixed with |
|
Definition
| milk, apple or orange juice |
|
|
Term
| advise the pt taking calcineurin inhibitors the importance of regular |
|
Definition
|
|
Term
| mTOR (mammalian target of rapamycin) inhibitors |
|
Definition
|
|
Term
| suppresses proliferation of B cells and T cells |
|
Definition
|
|
Term
| used to prevent rejection of transplanted kidneys |
|
Definition
|
|
Term
| side effects of mTOR inhibitors |
|
Definition
| risk fo infection, elevated serum lipids, rash, acne, anemia, thrombocytopenia, joint pain, diarrhea, hypokalemia, sever complications in liver and lung receipients, thrombosis in transplanted kindey |
|
|
Term
| everolimus can also cause |
|
Definition
|
|
Term
| mTOR should be taken with |
|
Definition
|
|
Term
| grapefruit juice raises serum drug levels of |
|
Definition
|
|
Term
|
Definition
| cyclophosphamide, azathioprine, mycophenylate mofetil |
|
|
Term
| prevents rejection of transnplanted tissue by killing B and T lymphocytes |
|
Definition
|
|
Term
| side effects of cytotoxic agents |
|
Definition
| bone marrow supression, neutropenia, thrombocytopenia, infection, GI disturbances, hair loss, reduced fertility, increased risk of malignancy |
|
|
Term
| nursing interventions for nursing interventions |
|
Definition
| stress importance of regular blood studies, protect patients from sources of infection |
|
|
Term
| folate antagonists/antimetabolic |
|
Definition
|
|
Term
| supresses B and T lymphocyte production, by interfering with folate metabolism |
|
Definition
|
|
Term
| methotrexate is used to treat |
|
Definition
| psoriasis, arthritis, various types of cancer, acute lymphoblastic leukemia, CNS prophylaxis with leukemia therpay, prevention of graft versus host disease after transplant |
|
|
Term
| side effects of folate antagonist |
|
Definition
liver damage,
dosage for cancer treatment can cause nausea, vomiting, rash, diarrhea, leukopenia, anemia, thrombocytopenia, headache, confusion, hair loss |
|
|
Term
| nursing interventinos for mthotrexate |
|
Definition
protect form infection,
stress need for regular blood tests, inspect skin for serious rash, sore throat, fever, bleeding |
|
|
Term
|
Definition
|
|
Term
| affects the biosnthesis of DNA and RNA |
|
Definition
|
|
Term
| cytarabine is used to treate |
|
Definition
| AML, ALL, non-hodgkin lymphoma |
|
|
Term
| side effect of pyrimidine analog |
|
Definition
| neutropenia, anemia, thrombocytopenia,anusea and vomiting, fever, stomatitis, liver damage, headache, conjucntivitis, pulmonary edema, cerbellar toxicity |
|
|
Term
| nursing interventions for cytarabine |
|
Definition
| monitor for excessive bruising, prolonged bleeding, avoid exposure to infections, teach good hygiene |
|
|
Term
|
Definition
|
|
Term
| destroys target cells by inhibiting DNA and preventing DN repari |
|
Definition
|
|
Term
| antrachylenes are used to treat |
|
Definition
| hodgkin and non hodgkn lymphoma, aml and ALL, and other cancers |
|
|
Term
| side effects of anthracyclines |
|
Definition
| neutropenia, anemia, thrombocytopenia, cardiotoxicity, nausea and vomiting, hair loss, stomatitis, anorexia, conjunctivitis |
|
|
Term
| nursing interventions for anthracyclines |
|
Definition
| inform patient that the drug will turn urin and sweat red and that extremitis may become pigmented, IV route only |
|
|
Term
|
Definition
| belimumab, rituximab, basilizimab, lymphocyte immune globulin |
|
|
Term
| used only to prevent rejection of kidney allogract and to treat systemic lupus erythematosus |
|
Definition
|
|
Term
| lymphocyte immune globulin is used for |
|
Definition
| renal transplants and aplastic anemia |
|
|
Term
| other monoclonal antibodies are used to treat |
|
Definition
| non-hodgkin lymphoma, systemic lupus erythematosus, some luekimas (ALL) |
|
|
Term
| TYROSINE KINASE INHIBITORS |
|
Definition
| imatinib, nilotinib, dasatinib |
|
|
Term
| inhibits proliferation and promotes death of cancer cells |
|
Definition
| tyrosine kinase inhibitors |
|
|
Term
| tryosine kinase inhibitors treat |
|
Definition
| chronic myelogenous leukemia, some GI tumors |
|
|
Term
| side effects of tyrosine kinase inhibitors |
|
Definition
| neutropenia, anemia, thrombocytopenia, nausea, diarrhea or constibation, myalgia, rash, edema, liver, injury, fluid retention, pulmonary edema, cardiac dysrhythmias |
|
|
Term
| nursing interventions for tyrosine kinase inhibitors |
|
Definition
| monitor resp status, reprot dyspnea, dedema, bleeding,infspect skin, stress to patient importance of blood tests, asses peripheral and apical pulses for irregularity,, take same time each day |
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