Term
| What diuretic must be used when there is a low GFR and/or severe edema? |
|
Definition
Furosamide (Lasix)
b/c most potent
|
|
|
Term
| What does adding glucuronic acid to a drug in the kidney do to it? |
|
Definition
| makes it a polar molecule and allows it to be excreted (detox) |
|
|
Term
|
Definition
| total clearance of the compound both in the urine, stored or metabolized |
|
|
Term
| What are examples of drugs that cause prerenal acute renal failure? (5) |
|
Definition
NSAIDS
ACE I/ARB
immunosuppressives
cyclosporin
IV contrast |
|
|
Term
| What are examples of drugs that cause Acute tubular necrosis? (2) |
|
Definition
aminoglycosides
cisplatin |
|
|
Term
| What are examples of drugs that cause acute interstitial nepritis? (6) |
|
Definition
NSAIDS
sulfa
PNC
allopurinol
rifampin
cimetadine
|
|
|
Term
| What are examples of drugs that cause post renal acute renal failure? (3) |
|
Definition
acyclovir
analgesics
methotrexate |
|
|
Term
| What are examples of drugs that cause nephrotic syndrome? (4) |
|
Definition
gold
NSAIDS
captopril
penicillamine |
|
|
Term
| What are examples of drugs that cause chronic renal failure? (4) |
|
Definition
litium
analgesic
cyclosporin
cisplatin |
|
|
Term
| What drugs/endongenous compounds are excreted through the OAT? (7) |
|
Definition
PAH
thiazide
furosamide
PNC
Cephalosporin
uric acid
salicylic |
|
|
Term
| What drugs are secreted through OCT 1? (5) |
|
Definition
creatinine
cimetadine
epi
histamine
tripethoprim |
|
|
Term
| What is the driving transport mechanism for the compounds transported by OCT1 across the basallateral membrane? |
|
Definition
|
|
Term
| What are the excretion methods by category I, II, and III drugs? |
|
Definition
cat I excreted soley by kidney
cat II not by the kidney
cat III combo |
|
|
Term
| Which category of drugs needs to be adjusted in renal failure patients? I, II, or III |
|
Definition
|
|
Term
| What type of drugs have a low volume of distribution? |
|
Definition
hydrophilic
those bound to protein |
|
|
Term
| What type of drugs have good volume of distribution? |
|
Definition
|
|
Term
| What can you do to decrease the toxicity of a category I drug and still maintain efficacy? |
|
Definition
increase the time between dose
reduce the maintance dose |
|
|
Term
| What occurs when you administer a drug that binds to albumin to a renal failure patient? |
|
Definition
| due to the hypoalbuminema there is less albumin for the drug to bind therefore there is a higher amount of free drug in the blood, which can cause increased toxicity |
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