Term
|
Definition
Anticoagulant, IV
-catalytically accelerated Antithombin III interaction with thrombin to inactivate it and leads to inhibition of blood clotting
Use w/
-DVT, PE
-DIC
-major abdominal surgery, etc
start with heparin and continue with oral anticoagulants
*contraindicated w/anti-platelet drugs! |
|
|
Term
|
Definition
Anticoagulant, orally effective
-blocks epoxide reductase leading to no gamma-carboxylation of certain coagulation proteins
-in vivo induce hypocoagulability
-chronic alcoholics increased conc of warfarin in blood
*dont give to preg women! crosses placenta!! |
|
|
Term
|
Definition
Heparin Neutralizer
-use if bleeding occurs with use of heparin |
|
|
Term
|
Definition
Fibrinolytic inhibitors
-competitively inhibits plasminogen activation |
|
|
Term
| Vitamin K1 (phytonadione) |
|
Definition
|
|
Term
|
Definition
Antiplatelet drugs
-irreversible acetylates COX--> inhibits thromboxane A2 syntheses
-inhibit platelet content release and aggregation
-small does aspirin 325 mg/day--> prophylaxis of myocardial mortality |
|
|
Term
|
Definition
Antiplatelet drugs
*ADP Receptor Blocker
-with surgery for coronary stint
-transient ischemic attacks, complex strokes, unstable angina pectoris
*PRODRUG--> CYP2C19 if mutated will have higher CV event rate (PPI ihibit CYP2C19) |
|
|
Term
|
Definition
Antiplatelet drugs
GP IIB/IIIA Receptor Blocker
-adjuvent in percutaneous angioplasty for coronary thrombosis |
|
|
Term
|
Definition
*Fibrinolytic (enzyme)
-human protease enzyme synthesisized by the kidneys
-converts directly plasminogen to plasmin
*thrombolytic drug used for acute MI |
|
|
Term
|
Definition
*Fibrinolytic (enzyme)
*thrombolytic drug used for acute MI |
|
|
