Term
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Definition
| nonselective competitive alpha antagonist - not metabolized by COMT in liver |
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Term
|
Definition
| irreversible alpha antagonist |
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Term
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Definition
| alpha-1 antagonist (reversible) |
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Term
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Definition
| reversible alpha1 antagonist |
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Term
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Definition
| beta1 inhibitor (high doses beta2) |
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Term
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Definition
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Term
|
Definition
| non-selective beta blocker |
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Term
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Definition
| partial beta agonist (non selective) |
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Term
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Definition
| non selective beta blocker + alpha1 blcokage |
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Term
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Definition
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Term
|
Definition
| nonselective beta blocker (partial beta2 agonist) and alpha1 blocker |
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Term
|
Definition
| nonselective beta-competitive antagonist |
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Term
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Definition
| D1 receptor agonist. some alpha2 stimulation |
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Term
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Definition
| Nicotinic muscular or neurologic receptors |
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Term
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Definition
muscarinic receptor agonist (predom. M3)
crosses BBB poorly |
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Term
|
Definition
quarternary ester - nonselective muscarinic agonist
- not a substrate for Acetylcholine esterase |
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Term
|
Definition
nonselective muscarinic agonist (predom M3)
- partial agonist |
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Term
|
Definition
quarternary ester - nonselective cholinergic agonist (N and M receptors)
cannot be digested by acetylcholinesterase |
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Term
|
Definition
| nonselective muscarininc antagonist |
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Term
|
Definition
| tertiary amine - nonselective muscarinic antagonist |
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Term
|
Definition
nonselective muscarinic antagonist
(inhaled - predom M3) |
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Term
|
Definition
| nonselective antimuscarinic agent |
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Term
|
Definition
| competitive muscarinic antagonist (mainly GI/GU M3) |
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Term
|
Definition
muscarinic antagonist
tertiary amine with greater selection for M3 |
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Term
|
Definition
Nm agonist
- not digested by acetylcholinesterase
- hydrolyzed in plasma and liver by pseudocholinesterases
- may stimulatate ganglionic nicotinic Ach-R and cardiac muscarinic Ach-R |
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Term
|
Definition
- partial agonist at Ach-R
- competitive antagonist of Nm |
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Term
|
Definition
competitive Nm antagonist
- eliminated by spontaneous hydrolysis, no ganglionic block, no cardiac M2 block |
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Term
|
Definition
| competitive Nm antagonist |
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Term
|
Definition
| competitive antagonist at Nm receptor |
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Term
|
Definition
carbamate inhibitor of Ach-esterase
- does not penetrate BBB |
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Term
|
Definition
carbamate acetylcholinesterase inhibitor
- does not penetrate BBB |
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Term
|
Definition
| noncarbamate Ach-esterase inhibitor with short half life |
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Term
|
Definition
cholinesterase inhibitor
- crosses BBB readily |
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Term
|
Definition
| minimal binding, crosses the BBB, noncovalent Ach-esterase inhibitor |
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Term
|
Definition
| cholinesterase inhibitor - crosses the BBB |
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Term
|
Definition
| organophosphate Ach-esterase inhibitor |
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|
Term
| DFP (diisopropyl fluorophosphate) |
|
Definition
| organophosphate Ach-esterase inhibitor (not a drug) |
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Term
|
Definition
cholinesterase regenerator
- only useful in organophosphate toxicity |
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Term
|
Definition
direct sympathomimetic
- stimulates alphas and betas nonselectively (beta predom at low dose, alpha at high dose) |
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Term
|
Definition
| selectively stimulates alphas more than beta1 (but NO beta2) |
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Term
|
Definition
stimulates D1 > beta1 > alpha1
- does not cross BBB |
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Term
|
Definition
stimulates beta1 >> beta2 >> alpha1=alpha2
- racemic mixture (+ goes beta1 selective, alpha1 antagonist; - is alpha1 agonist) |
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Term
|
Definition
| causes release of endogenous norepinephrine and, at higher doses, dompamine and serotonin |
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Term
|
Definition
release of norepi from sympathetic neurons
- some adrenergic agonist action
- activates alphas and betas |
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Term
|
Definition
- precursor for meth drug
- stimluates release of NE from sympathetic neurons |
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Term
|
Definition
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Term
|
Definition
alpha2 agonist
- presynaptic symapthetic neurons --> decreased NE release |
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Term
|
Definition
nonselective beta-agonist
- metabolism in liver and tissues by COMT |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| selection serotonin agonist for 5-HT1B and 5-HT1D |
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Term
|
Definition
| selective serotonin antagonist 5-HT3 |
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Term
|
Definition
| selective serotonin 5-HT3 antagonist |
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Term
|
Definition
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|
Term
|
Definition
| D2 dopamine receptor antagonist |
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Term
|
Definition
| D2 antagonists and weak 5-HT3 antagonist, 5-HT4 agonist |
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Term
|
Definition
alters chloride channels for cell stabilization
- inhibit degranulation of mast cells and eosinophils |
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Term
|
Definition
chloride channel alteration (cell stabilizer)
- inhibit degranulation of mast cells and eosinophils |
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Term
|
Definition
inhibitor of histamine H1 receptors
- lipid soluble so can travel to CNS |
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Term
|
Definition
| 5-HT2 blocker and H1 blocker |
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Term
|
Definition
competitive inhibitor of H1 receptors
- does not cross BBB |
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Term
|
Definition
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Term
|
Definition
inhibits H+/K+ ATPase (proton pump inhibitor)
- racemic mixture |
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Term
|
Definition
S-isomer of omeprazole
- proton pump inhibitor (Na+/K+ ATPase) |
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Term
|
Definition
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Term
|
Definition
endogenous agonist
- activates cholinergic receptors
- M1, M3, M5 - Ca2+ influx (via IP3 and DAG)
- M2 & M4 - decrease cAMP and K+ channels opened
- NM and NN - depolarization due to Na+,K+ channels opening |
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Term
|
Definition
| ganglionic blocker of sympathetics and parasympathetics |
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Term
|
Definition
| causes NE release from adrenergic terminals |
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Term
|
Definition
| 5-HT3 is ligand gated Na+, K+ channel 5-HT1-7 (except for 3) are GPCRs |
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Term
|
Definition
| 5HT4 agonist, 5HT3 antagonist |
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Term
|
Definition
4 receptors
H1 - GPCR (Gq)
H2 - GPCR (Gs)
H3 - GPCR (Gi)
H4 - GPCR (Gi) |
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