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Drug Induced Liver Disease
4th test Therapeutics
55
Biology
Post-Graduate
11/11/2008

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Term
Which Drugs cause Microvesicular Fat?
Definition
Tetracycline
Valproic acid
Term
Tetracycline and valproice acid cause what kind of liver toxicity?
Definition
Microvesicular fat
Term
Tetracycline and valproic acid cause macrovesicular fat in liver? T or F?
Definition
False. It is microvesicular fat
Term
Two drugs cause microvesicular fat in the liver? what are they? Hint T and VA
Definition
tetracycline and valproice acid
Term
What drugs cause Granulomatous?
Definition
Diltazem,
sulfa drugs
Quinidine
Term
Diltiazem, Sulfa drugs, and quinidine cause what?
Definition
Granulomatous
Term
Halothane and phenytoin and sulfamethazole cause what?
Definition
immunoallergic liver toxicity
Term
What drugs cause immunoallergic liver toxicity? Hint HPS
Definition
Halothane
Phenytoin
Sulfamethazole
Term
What drugs cause hepatocellular liver toxicity?
Definition
Isoniazid, trazazone; diclofenac, lovastatin, venaflexine
Term
Isoniazid; trazadone; diclofenac, and lovastatin cause what kinds of liver toxicity?
Definition
hepatocellular
Term
Amiodarone and tamoxifen cause what kinds of liver disease?
Definition
steatohepatitis
Term
what drugs cause steatohepatitis?
Definition
Amiodarone, tamoxifen
Term
Amiodarone and what else caue steatohepatitis?
Definition
Temoxifen
Term
What drugs causes autoimmune hepatotoxicity?
Definition
Nitrofurantoin; Lovastatin; minocycline,
Term
lovastatin; nitrofurantoin and minocycline causes what?
Definition
autoimmune
Term
Lovastatin causes what?
Definition
Autoimmune and Hepatocellular
Term
What drug causes both autoimmune and hepatocellular liver toxicity?
Definition
Lovastatin
Term
Methrotrexate and excess vitamin A causes what?
Definition
Fibrosis
Term
What kind of liver toxicity does nicotinic acid, cocaine and amphetamines cause?
Definition
Vascular Collapse.
Term
What drugs cause oncogenesis in the liver?
Definition
Androgens and oral contraceptives
Term
What drugs causes Mixed hepatic toxicity?
Definition
KAVA, Augmentin, carbamazepine, cyclosporine, trogliazone
Term
Kava, augmentin, carbamazepine, cyclosporine and troglitazone causes what?
Definition
Mixed Hepatic Disease
Term
What two drugs have been removed from the market due to toxicity of the liver?
Definition
Troglitazone, Bromfenac
Term
In the past ...... years troglitazone and bromfenac have been removed from the market?
Definition
Yes.
Term
Is Troglitazone causing hepatic failure believed to be a class effect of thiazolidnediones?
Definition
NO
Term
Drugs account for what percentages of hepatic failure in teh elderly?
Definition
25%
Term
What is Phase I metabolism
Definition
Oxidation and demethylation.
Cytocrhrom P450
Term
What are Phase II enzyems?
Definition
conjugation;
covalent bonds and glucuronic acid and sulfate and glutathione
Term
Is CP450 Phase I or phase II?
Definition
Phase I
Term
REduction; oxidation, and hydrolysis are a part of this kind of metabolism
Definition
Phase I
Term
When the enzymes are esterases and causes esters the metabolism is what?
Definition
Hydrolysis of Phase I
Term
Could Hydrolysis also be phase III?
Definition
Yes
Term
Acetaminophen is intrinsic or idosyncratic toxicity?
Definition
Intrinsic
Term
Describe intinsic hepatotocity
Definition
Dose dependent; predictable; slow onset and long duration; respond to lowering offending agent.
Often associated with genetic or acquired abnormality in metabolic pathway
Term
If you have intrinsic hepatotoxicity do you have to totally take the person off of the drug?
Definition
No. just reduce.
Term
what are haptens?
Definition
Immune mediated reactive metabolites
Term
Idiosyncratic actually destroys liver cells? true or F?
Definition
True
Term
Disruption of actin filaments causes what?
Definition
It causes an effect on bile excretion to cause drug accumulation
Term
When you damage MRP(3) a transport protein via idiosyncratic causes what is the effect on bile and hepatotoxins?
Definition
prevent the excretion of them so there is drug accumulation.
Term
What does zonal hepatic injury mean?
What does non zonal hepatic injury mean?
Definition
Zonal is limited to specific zones.
Nonzonal means to diffuse the injury.
Term
Idiosyncratic is likely to cause zonal or non z0nal?
Definition
non zonal...
Immune mediated injury causes zonal
Term
for idiosyncratic must the offending agent be removed to resolve/
Definition
yes
Term
what are enzymes responsible for metabolic idosyncrasy?
Definition
CYP2c9
CYP1a2
Term
CYP1A2 and CYP2C9 are responsible for intrinic or idosyncratic?
Definition
idiosyncratic
Term
What are the liver marers for Idiosyncratic rxns?
Definition
LKM and LM
LKM targets anti liver kidney microsomial
LM is anti liver microsomal; targets cyp1a2
Term
What doesLKM target? What does LM target?
Definition
LKM targets cyp2c9
lm targets 1A2
Term
Does ALK Phos increase in Liver disease?
Definition
YES!
Term
Nitrofurantoin; methyldopa; and antituberculosis drugs can cause necroinflammatory disease? yes!!!
Definition
Term
Do microvesicular or macrovesicular displace hepatocyte nucleus?
Definition
macro
Term
Steatosis Presentation. When you have AST and ALT 20 time above normal and bilirubin 10 times above normal and alkaline 2 time above normal... is it macrovsesicular or micro?
Definition
Micro. Macro have increases that are 4 times less than micro.
Term
Can steatosis cause pancreatitis?
Definition
Yes
Term
What drugs cause microvesicular steatosis?
Ethanol; glucocorticoids; Methotrexate
Definition
Term
What drugs cause macrovesicular steatosis?
Definition
Asparaginase; valproate; amiodarone
Term
Macrovesicular steatosis always cause necrosis?
Definition
sometimes
Term
What drugs cause macrovesicular disease?
Asparaginase; valproate; amiodarone
Definition
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