*MDD
*OCD

*Panic disorder +/- agoraphobia

*Bulimia

*PMDD 

*MDD

*OCD
*SAD
*Panic Disorder +/- agoraphobia

*PTSD

*PMDD 

*MDD
*OCD
*SAD
*GAD
*Panic disorder+/- agoraphobia

*PTSD
*PMDD 

*OCD

*Social Anxiety disorder 

*(not approved for MDD)

*MDD

*GAD
*SAD
*Panic disorder +/- agroraphobia 

*MDD
*GAD

*Pain from diabetic peripheral neuropathy, FM, Chronic musculoskeletal pain 

*MDD
*Seasonal affective disorders

*Adjunct in smoking cessation 

*MDD

*Low dose for insomnia (off label)

*MDD

*Noctural enuresis (Imipramine)

*Insomnia (Doxepin)

*OCD (Clomipramine)

*Neuropathic pain and migraine prophylaxis (unlabeled use)

*Panic disorder +/- agoraphobia

*Seizure disorders

*Status epilepticus

*Sedation/amnesia

*ETOH withdrawal/agitation

*Various seizure disorders

*Conscious sedation

*Tx of schizo

*Tx of bipolar disorder (acute mania or mixed episodes; maintenance)

*Tx refractory schizo

*Recurrent suicidal behavior risk reduction in schizo/shizoaffective disorder

*ADHD

*Sx management of narcolepsy

*depression in the medically ill/ICU (unlabeled use)

*Partial seizures with complex symptomatology (psychomotor, temporal lobe)

*mixed seizure patterns

*tx of chronic pain syndromes 

*Generalized tonic-clonic and complex partial seizures

*prevention os seizures following head trauma/NS

*Maintenace tx of bipolar disorder

*Tx of seizures in Lennox-Gastaut syndrome

*Not FDA approved: initial tx for newly dx'd partial epilepsy, idiopathic generalized epilepsy, and mixed seizure disorders

*Adjunct for partial seizures with and without secondary generalized seizures

*management of postherpetic neuropathy

*restless leg syndrome

*Adjunctive for partial seizures in adults

*FM
*Management of peripheral neuropathies 

*Add-on therapy for complex partial seizures in adults who are refractory to several AED's

*Monotherapy for infantile spasms (orphan drug)

*Monotherapy and adjunctive therapy in pts with multiple seizure types (including absence seizures)

*Mania assoc with bipolar disorder

*Migraine prophylaxis

*Partial seizures

*Lennox-Gastaut syndrome

*Alternate 1st line or add-on therapy to levodopa

*restless leg syndrome

*Early PD dz-can be used as inital therapy to improve sx's  in pt with early PD

*Later dz-adjunctive management when levodopa efficacy is deteriorating

*Early PD dz-may be helpful in pts who present with mild tremor 

*Later dz-May be used to enhance the effects of levodopa and may help with drooling

*Early PD dz-may be used as inital theapy in mild dz (resting tremor)

*later dz-adjunct tx (in pts with levodopa-induced dyskinesias)

*Early use (mild-mod pain) d/t migraines

*Partial response or migraine recurrence more likely with later use (mod-severe pain)

*Management of DMII (mono or combo therapy)

*Management of insulin resistance in PCOS

*No longer 1st line for Osteoporosis b/c of increased risk of breast CA, VTE, CVA and perhaps CAD

*Persistent menopausal sx's

*Women with an indication for antiresorptive therapy who cannot tolerate other drugs

*Prevention and tx of osteoporosis

*Risk reduction for women with invasive breast CA

*Prevention and tx of osteoporosis (note: not pamindronate)

*Hypercalcemia assoc with malignancy and Pagets dz

*Tx of osteoporosis

*Prevention of skeletal-related events in pts with bone metastases from solid tumors

*Palliative tx of hyperthyroidism as an adjunct to ameliorate hyperthyroidism in prep for surgery or RAI therapy

*Management of thyrotoxic crisis