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DNA synthesis
proteins required for DNA synthesis
16
Biology
Undergraduate 2
04/28/2011

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Term
Helicase
Definition
catalyzes the breaking of hydrogen bonds between base pairs to open the double helix
Term
Single-strand DNA-binding proteins (SSBPs)
Definition
stabilizes single-stranded DNA
Term
Topoisomerase
Definition
breaks and rejoins the DNA double helix to relieve twisting forces caused by the opening of the double helix
Term
Primase (leading strand)
Definition
catalyzes the synthesis of RNA primer
Term
DNA polymerase III (leading strand)
Definition
extends the leading strand
Term
Sliding clamp (leading strand)
Definition
holds DNA polymerase in place during strand extension
Term
Primase (lagging strand)
Definition
Catalyzes the synthesis of the RNA primer on an Okazaki fragment
Term
DNA polymerase III (lagging strand)
Definition
extends and Okazaki fragment
Term
Sliding clamp (lagging strand)
Definition
holds DNA polymerase in place during strand extension
Term
DNA polymerase I
Definition
removes the RNA primer and replaces it with DNA
Term
DNA ligase
Definition
catalyzes the joining of Okazaki fragments into a continuous strand
Term
Lagging strand
Definition
the strand that is synthesized in the opposite direction of the replication fork
Term
Leading strand
Definition
(continuous strand) leads into the replication fork and is synthesized continuously
Term
origin of replication
Definition
the specific strand of bases where the replication bubble forms
Term
Telomore
Definition
nucleoprotein complexes that cap the ends of chromosomes (overhang), prevent fusion of chromosomes, get shorter as we get older
Term
Telomerase
Definition
catalyzes the synthesis of DNA from an RNA template, carries an RNA molecule with it that acts as a built in template allowing telomerase to add DNA onto the end of a chromosome and prevent it from getting shorter
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