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DNA Replication
Biology 200 Lecture Notes
12
Biology
Undergraduate 2
07/18/2011

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Term
Helicase (Opening the Helix)
Definition
Catalyzes the breaking of H-bonds between base pairs to open DNA helix.
Term
SSBPs (Opening the Helix)
Definition
Stabilizes single-stranded DNA.
Term
Topoisomerase (Opening the Helix)
Definition
Breaks and rejoins DNA double helix to relieve twisting forces caused by opening.
Term
Primase (Leading Strand Synthesis)
Definition
Catalyzes synthesis of RNA primer.
Term
DNA Polymerase III (Leading Strand Synthesis)
Definition
Extends the leading strand.
Term
Sliding Clamp (Leading Strand Synthesis)
Definition
Holds DNA polymerase in place during strand extension.
Term
Primase (Lagging Strand Synthesis)
Definition
Catalyzes synthesis of RNA primer on an Okazaki fragment.
Term
DNA Polymerase III (Lagging Strand Synthesis)
Definition
Extends an Okazaki fragment.
Term
Sliding Clamp (Lagging Strand Synthesis)
Definition
Holds DNA polymerase in place during strand extension.
Term
DNA Polymerase I (Lagging Strand Synthesis)
Definition
Removes the RNA primer and replaces it with DNA.
Term
DNA Ligase (Lagging Strand Synthesis)
Definition
Catalyzes joining of Okazaki fragments into continuous strand.
Term
What happens when two replication bubbles approach each other on a linear chromosome?
Definition
Tension builds up as the twisting helices are strained.
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